2023
DOI: 10.1016/j.scitotenv.2022.159656
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Enantioselectivity in the toxicological effects of chiral pesticides: A review

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Cited by 32 publications
(9 citation statements)
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“…Chirality is an essential attribute of nature and an important symbol of the difference between living matter and nonliving matter. The physiology of many chemical substances carries out the chemical processes in the phenomena of life in a highly asymmetric environment. , The generation of function is often attributed to the recognition and matching of chiral molecules. , With the development of research, people’s understanding of life processes is deepening, and the study of chirality has aroused wide interest in the scientific community. In recent years, chiral pesticides, which contain only one or two highly effective isomers, have been widely used in pest control in agricultural planting because of their advantages of high efficiency, low toxicity, strong selectivity, and low residual amount. As a key pesticide for disease prevention and control in agriculture, agricultural fungicides have also been widely studied in recent years. Among the current commercial agricultural fungicides, nearly 32% are chiral, and most of the biological activity and toxicity of chiral fungicides are closely related to their configuration. Therefore, effectively enriching chiral fungicides with biological activity and maximizing the utilization rate of chiral pesticides through controlled release is still a serious challenge …”
Section: Introductionmentioning
confidence: 99%
“…Chirality is an essential attribute of nature and an important symbol of the difference between living matter and nonliving matter. The physiology of many chemical substances carries out the chemical processes in the phenomena of life in a highly asymmetric environment. , The generation of function is often attributed to the recognition and matching of chiral molecules. , With the development of research, people’s understanding of life processes is deepening, and the study of chirality has aroused wide interest in the scientific community. In recent years, chiral pesticides, which contain only one or two highly effective isomers, have been widely used in pest control in agricultural planting because of their advantages of high efficiency, low toxicity, strong selectivity, and low residual amount. As a key pesticide for disease prevention and control in agriculture, agricultural fungicides have also been widely studied in recent years. Among the current commercial agricultural fungicides, nearly 32% are chiral, and most of the biological activity and toxicity of chiral fungicides are closely related to their configuration. Therefore, effectively enriching chiral fungicides with biological activity and maximizing the utilization rate of chiral pesticides through controlled release is still a serious challenge …”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, the development and application of chiral pesticides are of increasing significance in modern crop protection. Generally, only one single enantiomer is notably active against the target, while the other paired isomer is less or inactive, thus offering an ideal approach to reduce the excess use of chemical agents by the elimination of the less effective stereoisomer in the ingredients. , For example, the herbicidal action of metolachlor as developed by Syngenta is mainly attributed to the S -configured single enantiomer, while its opposite stereoisomer, R -metolachlor is basically inactive and displays notable toxicity (10 times higher than S -metolachlor). , An et al found that 1 S, 4 R -(−)-benzovindiflupyr, a widely used commercial fungicide, exhibited 1.7–54.5 times greater activity against six specific phytopathogens compared to the other enantiomer 1 R, 4 S -(+)-benzovindiflupyr (Figure A) . According to recent statistical data, approximately 44% of registered agrochemicals feature at least one stereogenic element, and the number of chiral pesticides continues to increase dramatically every year .…”
Section: Introductionmentioning
confidence: 99%
“…The latest survey data reveal that many kinds of organic compounds are identified as environmental pollutants, for example, azo dyes, dioxins, nanomaterials, per- and polyfluoroalkyl substances, personal care products, pesticides, pharmaceuticals, phthalates, polybromated diphenyl esters, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons. Among these pollutants, pesticides are the most concerned class of chemicals . The main reason is that less than 0.1% of pesticides applied in agricultural production could really reach the target pests, and more than 99.9% remain in the environment and become pesticide pollutants. , It is estimated that globally there are about 7.9 billion pounds of pesticide used annually, of which chiral pesticides account for ∼30.4%, and the proportion continues to show an upward tendency. , This means that a large quantity of residual pesticides belong to chiral pollutants. Significantly, the most unique character of chiral pesticide pollutants is that the molecular structure contains at least one asymmetric center, resulting in the existence of one or more pairs of enantiomers, and usually the toxic effects of different enantiomers are quite different on human health. , For this reason, only the dissection of the toxicological effects and microscopic mechanisms of chiral pesticide pollutants at the enantiomeric scale can we scientifically assess their health risks to the human body.…”
Section: Introductionmentioning
confidence: 99%
“…16,17 It is estimated that globally there are about 7.9 billion pounds of pesticide used annually, of which chiral pesticides account for ∼30.4%, and the proportion continues to show an upward tendency. 18,19 This means that a large quantity of residual pesticides belong to chiral pollutants. Significantly, the most unique character of chiral pesticide pollutants is that the molecular structure contains at least one asymmetric center, resulting in the existence of one or more pairs of enantiomers, and usually the toxic effects of different enantiomers are quite different on human health.…”
Section: ■ Introductionmentioning
confidence: 99%