Enantioseparation of pharmaceutical compounds by multiplexed capillary electrophoresis using highly sulphated α-, β- and γ-cyclodextrins☆

Chiral Screening Methods for Pharmaceutical Analysis and Purification in an Industrial Laboratory

“…15%), which forces us to perform the analysis in duplicate, as shown in Figure 19. The false negatives are attributed to injection problems and lack of conditioning of a particular column in the capillary array [46]. The system has been extensively utilized to screen commercially available compounds; however, more developmental work is needed to overcome the aforementioned restrictions.. We have so far not evaluated which highly sulfated cyclodextrin has the largest frequency of success.…”

“…The samples from examples shown in this chapter are proprietary unless stated otherwise. Further details on the capillary electrophoresis screen can be found in a paper by Saavedra et al [46]. Columns All Chiracel and Chiralpack columns are from Chiral Technologies, the Astec-Chirobiotic phases from Sigma-Aldrich, the Whelk columns from Regis, and the TBB and DBB phases from Kromasil.…”

“…The parallel CE screen is still under development, and the evaluation study was published in 2008 [46]. In general, it has the same advantage as the Sepmatix system.…”

“…The current multiplex configuration does not allow for 24-h operation since every run needs to be set up manually before analyzing the samples. Joule heating plays a role as well: inducing nonlinear behavior that affects the elution time [46]. Figure 19 (p. 244) shows a typical output of the chiral CE.…”

Chiral selectors in CE: Recent developments and applications

“…This review reveals that sulfated CD derivatives, and particularly HS‐CDs (Fig. A), have received the most attention and appear to be the most effective, and thus the most popular negatively charged CSs .…”