Enantioseparation of racemic aminoglutethimide using asynchronous simulated moving bed chromatography

Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

“…The outstanding performance of the VariCol process was confirmed by experimental and computational studies [62][63][64][65][66]. Gong et al obtained 29 % higher productivity and the same purity as conventional SMB for the separation of guaifenesin enantiomers [62].…”

“…Gong et al obtained 29 % higher productivity and the same purity as conventional SMB for the separation of guaifenesin enantiomers . Lin et al applied the VariCol process for the separation of amino glutethimide and demonstrated that the required purity could be achieved even though fewer columns were used than in conventional SMB .…”

Semi-continuous and continuous processes for enantiomeric separation

“…The key advantage of an SMB process over batch chromatography is the cost-effective potential to enhance productivities and to reduce the solvent consumption compared to conventional discontinuous processes. 264,265 Most chromatographic methods are not considered environmentally friendly and do not follow the principles of green chemistry. Improvements by eliminating hazardous reagents and reducing the use of flammable and toxic solvents must be put into practice.…”

Isobutylhydroxyamides from Sichuan Pepper and Their Protective Activity on PC12 Cells Damaged by Corticosterone

“…The phytochemical investigation revealed a variety of secondary metabolites comprising alkaloids, lignans, flavonoids, − and terpenoids , together with essential oils. , As characteristic constituents in the genus Zanthoxylum (Rutaceae), isobutylhydroxyamides have been reported to be the tingling and anesthetic component based on the cis and trans double bonds in the structure. ,− Interestingly, isobutylhydroxyamides with at least one chiral carbon were obtained as racemic mixtures. ,,, The racemic mixtures have not been separated successfully until now. However, in the areas of pharmaceuticals and food development, chiral enantiomers are receiving much more attention than before, and chiral drugs seem to be very stereoselective. , Thus the chemical and bioactive functions of optically pure isobutylhydroxyamides still remain underexploited. The CH 2 Cl 2 and EtOAc fractions from the 95% ethanol extract of Sichuan pepper exhibited a protective effect on corticosterone-treated PC12 cells.…”

“…However, in the areas of pharmaceuticals and food development, chiral enantiomers are receiving much more attention than before, and chiral drugs seem to be very stereoselective. 20,21 Thus the chemical and bioactive functions of optically pure isobutylhydroxyamides still remain underexploited. The CH 2 Cl 2 and EtOAc fractions from the 95% ethanol extract of Sichuan pepper exhibited a protective effect on corticosterone-treated PC12 cells.…”