Enantioseparation Properties of the Biselector Chiral Stationary Phase Derived from Amylose Tris(phenylcarbamate) and Amylose Tris(benzoate)

Abstract

In order to investigate the enantioseparation property of the biselector chiral stationary phase derived from polysaccharide, a new biselector chiral stationary phase was prepared by coating a blend of two amylose derivatives on an aminated silica gel. The blend consisted of amylose tris(phenylcarbamate) and amylose tris(benzoate) at a glucose unit ratio of 1:1 (mol/mol). For the sake of enantioseparation comparison, the corresponding single selector chiral stationary phases were also prepared with the two individual amylose derivatives. The enantioseparation ability of these chiral stationary phases was evaluated by using structurally various chiral analytes. The biselector chiral stationary phase showed an overall improved enantioseparation ability in comparison with the two single selector chiral stationary phases. The effect of alcohols in mobile phase on the enantioseparation of the biselector chiral stationary phase was also discussed.

Preparation and Enantioseparation of Biselector Chiral Stationary Phases Based on Amylose and Chitin Derivatives

“…[26][27][28][29] Some of these CSPs exhibited better enantioseparation performance than individual CSPs to some extent. Therefore, the above observed better enantioseparation capability and the strong solvent resistance of chitin derivatives encouraged us to explore the blend of amylose derivatives and chitin derivatives to enhance the stability and chiral separation ability of amylose derivative CSPs.…”