Encapsulated phenolic compounds from
            <i>Ferula gummosa</i>
            leaf: A potential phytobiotic against
            <i>Campylobacter jejuni</i>
            infection

Kamelankafi, Maryam; Bolvari, Nadiyeh Ebrahimi; MohammadPour, Safura; Moghadam, Shadi Kafshchian; Shafaei, Negin; Karimi, Ehsan; Oskoueian, Ehsan

doi:10.1111/jfpp.16802

Cited by 13 publications

(6 citation statements)

References 47 publications

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“…Microencapsulation is simple, low cost, and one of the approaches to protect, reduce toxicity and improve the stability of natural bioactive components. [ 10 ] Plant phenolic compounds are capable of alleviating the toxicity of heavy metals. Nanoniosome‐loaded Myristica fragrans phenolic compounds (NLMP) have been effective in reducing L‐asparaginase hepatotoxicity in mice.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the cytotoxic activity of sorafenib‐loaded camel milk casein nanoparticles against hepatocarcinoma cells

Mittal,

Mahala,

Dhanawade

et al. 2024

Biotechnology Journal

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Sorafenib, a multikinase inhibitor is used to treat hepatocellular and renal carcinoma. However, a low solubility impedes its bioavailability and thus, effectiveness. This study aims to enhance its effectiveness by using novel camel milk casein nanoparticles as a delivery system. This study evaluates the cytotoxicity of sorafenib encapsulated in camel milk casein nanoparticles against human hepatocarcinoma cells (HepG2 cells) in vitro. Optimal drug loaded nanoparticles were stable for 1 month, had encapsulation efficiency of 96%, exhibited a particle size of 230 nm, zeta potential of −14.4 and poly disparity index of 0.261. Treatment with it led to cell morphology and DNA fragmentation as a characteristic of apoptosis. Flow cytometry showed G1 phase arrest of cell cycle and 26% increased apoptotic cells population upon treatment as compared to control. Sorafenib‐loaded casein nanoparticles showed 6‐fold increased ROS production in HepG2 cells as compared to 4‐fold increase shown by the free drug. Gene and protein expression studies done by qPCR and western blotting depicted upregulation of tumor suppressor gene p53, pro‐apoptotic Bax, and caspase‐3 along with downregulated anti‐apoptotic Bcl‐2 gene and protein expression which further emphasized death by apoptosis. It is concluded regarding the feasibility of these casein nanoparticles as a delivery system with enhanced therapeutic outcomes against hepatocellular carcinoma cells.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the cytotoxic activity of sorafenib‐loaded camel milk casein nanoparticles against hepatocarcinoma cells

Mittal,

Mahala,

Dhanawade

et al. 2024

Biotechnology Journal

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“…Phenolic elements originating from herbal plants have garnered a lot of attention due to their effective anti-inflammatory, antitumor, antioxidant, antiviral, and anticancer agents [ 4 , 5 , 6 , 7 , 8 ]. The main phenols are rosmarinic acid (RA) and salvianolic acids (SAs), represented by salvianolic acids I, A, B, and C. Topical or local application of RA to the skin has demonstrated potential to hasten wound healing and reduce the risk of skin cancer in murine models [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Healing of Skin Wounds in Rats Using Creams Based on Symphytum Officinale Extract

Mârza,

Dăescu,

Purdoiu

et al. 2024

IJMS

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Rosmarinic acid is a well-known natural antioxidant and anti-inflammatory compound, and it is one of the polyphenolic compounds found in comfrey plants. Comfrey root also contains allantoin, which helps with new skin regeneration. This study aimed to investigate the healing and skin regeneration process of skin wounds in Wistar rats using creams based on comfrey extract and to correlate the results with active compounds in the extract. The obtained results showed that comfrey root is rich in bioactive compounds, including allantoin, salvianolic acid, and rosmarinic acid, which are known for their great free radical scavenging activity, and the high antioxidant activity of the extract may be mainly due to these compounds. The obtained extract has an antimicrobial effect on Staphylococcus aureus (1530.76/382.69), Escherichia coli (6123.01/6123.01), and Pseudomonas aeruginosa (6123.01/6123.01). The macroscopic evaluation and the histological analysis of the skin defects 14 days after the intervention showed faster healing and complete healing in the skin excisions treated with oil-in-water cream with 20% extract of comfrey as the active ingredient.

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“…Previous studies on Ferula have focused on the analysis of its chemicals and validation of their medicinal value ( Mohammadhosseini et al., 2019 ); for instance, the natural extract of Ferula has been reported to exhibit antibacterial, anticancer, antioxidant and melanogenesis inhibitory effects ( Charmforoshan et al., 2019 ; Kamelan Kafi et al., 2022 ). Although there is a wealth of information on the biological activity of Ferula , few studies have simultaneously compared multiple types of Ferula species simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Quality evaluation of four Ferula plants and identification of their key volatiles based on non-targeted metabolomics

Jiang,

Peng,

et al. 2024

Front. Plant Sci.

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IntroductionFerula is a traditional, edible, and important medicinal plant with high economic value. The distinction between edible and non-edible Ferula remains unclear.MethodsIn this study, headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry (HS-SPME/GC-MS) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) non-targeted metabolomics techniques were used to systematically and comprehensively analyse secondary metabolites in the leaves and roots of four species of Ferula, considering their edibility.ResultsA total of 166 leaf volatile organic compounds (VOCs) and 1,079 root metabolites were identified. Additionally, 42 potential VOCs and 62 differential root metabolites were screened to distinguish between edible and non-edible Ferula. Twelve volatile metabolites were specific to F. feurlaeoides, and eight compounds were specific to the three edible Ferula species. The results showed that compounds containing sulphur, aldehydes, and ketones, which produce pungent odours, were the primary sources of the strong odour of Ferula. The root differential metabolites include 13 categories, among which the high concentration group is organic acids, amino acids, terpenoids and fatty acids. The bioactive metabolites and VOCs in the roots exhibited species-specific characteristics. VOCs with various odors were linked to the distribution of root metabolites in both edible and non-edible Ferula plants. The screened root markers may contribute to the formation of characteristic VOCs.DiscussionThis study identified the difference in flavour between edible and non-edible Ferula plants and, for the first time, demonstrated the contribution of the efficacy of Ferula root to the unique flavour of the above-ground parts of Ferula. These results provide a theoretical basis for selecting Ferula for consumption and help evaluate the quality of different species of Ferula. Our findings may facilitate food processing and the further development of Ferula.

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Encapsulated phenolic compounds from Ferula gummosa leaf: A potential phytobiotic against Campylobacter jejuni infection

Cited by 13 publications

References 47 publications

Evaluation of the cytotoxic activity of sorafenib‐loaded camel milk casein nanoparticles against hepatocarcinoma cells

Evaluation of the cytotoxic activity of sorafenib‐loaded camel milk casein nanoparticles against hepatocarcinoma cells

Healing of Skin Wounds in Rats Using Creams Based on Symphytum Officinale Extract

Quality evaluation of four Ferula plants and identification of their key volatiles based on non-targeted metabolomics

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