Encapsulating bioactive materials in sonochemically produced micro- and nano-spheres

Grinberg, Olga; Shimanovich, Ulyana; Gedanken, Aharon

doi:10.1039/c2tb00006g

Cited by 17 publications

(28 citation statements)

References 27 publications

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“…Upon the collapse of the bubble, chemical bonds can be broken/formed due to the development of very high local temperatures (.5,000°C). 1 In the preparation of nano Penicillin and nano Vitamin B 12 , the material molecules are naturally drawn to the bubble surface, creating a shell of the material molecules around the bubble. During implosion, the molecules shell collapses into the bubble center and thereby creates a nanoparticle (NP) that contains many small molecules (a magnification of the NP is presented in the last phase of the process described in Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…Several articles suggesting the conjugation or encapsulation of antibiotics/ Vitamin B 12 with/into NPs [21][22][23][24][25] have been published; however, the formation of nanoantibiotics was reported only in the case of Nystatin 26 following wet milling of the bulk form material for 4 hours. To the best of our knowledge, the production of Vitamin B 12 NPs has not been yet reported.…”

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confidence: 99%

“…By synthesizing NPs of Vitamin B 12 and Penicillin, their biological and chemical activity would increase as well as their penetration depth within the skin and the underlying tissue. Recently, we showed that organic NPs (ONPs) can be detected within tissues 17 by a novel optical iterative technique, 17,20 and their skin penetration ability indeed increased with their size reduction.…”

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confidence: 99%

“…11 This method was later extended to organic molecules where solutions of the organic compounds were sonicated under ambient conditions and NPs of the organic compounds were prepared. Using the sonication technique, several organic nanomaterials were synthesized, 12 such as enzyme (amylase) NPs, 13,14 tannic acid NPs, or even RNA NPs. 15,16 This study focuses on two organic materials, Penicillin and Vitamin B 12 .…”

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confidence: 99%

“…Using the sonication technique, several organic nanomaterials were synthesized, 12 such as enzyme (amylase) NPs, 13,14 tannic acid NPs, or even RNA NPs. 15,16 This study focuses on two organic materials, Penicillin and Vitamin B 12 . In addition to these two organic materials, other materials like tannic acid and more, [12][13][14][15][16][17] were synthesized in a similar way by us and others.…”

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confidence: 99%

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Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles

Yariv

Lipovsky

Gedanken

et al. 2015

IJN

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Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B 12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B 12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B 12 nanoparticles (NPs) were found to be 70 and 120–180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B 12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical field.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles

Yariv

Lipovsky

Gedanken

et al. 2015

IJN

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Sono‐Assembly of Highly Biocompatible Polysaccharide Capsules for Hydrophobic Drug Delivery

Wang

Yan

et al. 2013

Adv Healthcare Materials

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Cells like sugar. General synthesis and potential of intracellular hydrophobic drug delivery of single-component polysaccharide capsules are pursued. The capsules can be generally assembled through hydrogen bonding networks but show striking shell robustness. The evidenced cell internalization, stimuli-responsiveness to local pH changes and high biocompatibilities of the capsules specifically favor their potential intracellular drug delivery.

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Sonochemistry‐Assembled Stimuli‐Responsive Polymer Microcapsules for Drug Delivery

Wang

et al. 2018

Adv Healthcare Materials

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Stimuli-responsive polymer microcapsules (PMs) fabricated by the sonochemical method have emerged for developing useful drug delivery systems, and the latest developments are mainly focusing on the synthetic strategies and properties such as structure, size, stability, loading capacity, drug delivery, and release. There, the primary attribution of sonochemistry is to offer a simple and practical approach for the preparation of PMs. Structure, size, stability, and properties of PMs are designed mainly according to synthetic materials, implementation schemes, or specific demands. Numerous functionalities of PMs based on different stimuli are demonstrated: targeting motion in a magnetic field or adhering to the living cells with sensitive sites through molecular recognition, and stimuli-triggered release including enzymatic catalysis, chemical reaction as well as physical or mechanical process. The current review discusses the basic principles and mechanisms of stimuli effects, and describes the progress in the application such as targeted drug systems and controlled drug systems, and also gives an outlook on the future challenges and opportunities for drug delivery and theranostics.

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Encapsulating bioactive materials in sonochemically produced micro- and nano-spheres

Cited by 17 publications

References 27 publications

Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles

Enhanced pharmacological activity of Vitamin B12 and Penicillin as nanoparticles

Sono‐Assembly of Highly Biocompatible Polysaccharide Capsules for Hydrophobic Drug Delivery

Sonochemistry‐Assembled Stimuli‐Responsive Polymer Microcapsules for Drug Delivery

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