2008
DOI: 10.1093/ndtplus/sfn109
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Encapsulating peritoneal sclerosis following renal transplantation despite tamoxifen and immunosuppressive therapy

Abstract: Encapsulating peritoneal sclerosis (EPS) is a rare disease in patients who have undergone peritoneal dialysis (PD). We report a case of EPS following renal transplantation that highlights important clinical issues. Initially, a presumptive diagnosis of EPS was made following surgical and pathological findings at the time of cholecystectomy. CT imaging at this time did not confirm the diagnosis. The patient continued PD and commenced tamoxifen. Prior to and immediately following transplantation, further CT imag… Show more

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Cited by 14 publications
(26 citation statements)
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“…The data in this study lend further support to the UK EPS and ISPD guidelines on EPS which state that the optimal approach to patients on long duration PD is currently unclear but routine pre-emptive switching to haemodialysis or screening for EPS after a specified time on PD are not recommended (Woodrow et al 2009, Brown E et al 2010. Indeed many of the cases of EPS in this study and other studies (Fieren et al 2007, de Freitas DG et al 2007, Brown M et al 2009 occurred after stopping PD. Thus pre-emptive switching to haemodialysis could potentially be associated with development of EPS rather than being preventive of EPS and at present there is no data showing any benefit from such a policy.…”
Section: Screening For Epssupporting
confidence: 58%
“…The data in this study lend further support to the UK EPS and ISPD guidelines on EPS which state that the optimal approach to patients on long duration PD is currently unclear but routine pre-emptive switching to haemodialysis or screening for EPS after a specified time on PD are not recommended (Woodrow et al 2009, Brown E et al 2010. Indeed many of the cases of EPS in this study and other studies (Fieren et al 2007, de Freitas DG et al 2007, Brown M et al 2009 occurred after stopping PD. Thus pre-emptive switching to haemodialysis could potentially be associated with development of EPS rather than being preventive of EPS and at present there is no data showing any benefit from such a policy.…”
Section: Screening For Epssupporting
confidence: 58%
“…Therapy with calcineurin inhibitors was not successful in patients after kidney transplantation. It is possible that they accelerated the peritoneal fibrosing process (4). For severe intestinal obstruction, the treatment of choice is timely surgical enterolysis.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, de Freitas et al . [ 2 ] recently reported a case of EPS following renal transplantation despite treatment with tamoxifen and immunosuppression. Also, Bowers et al .…”
Section: Discussionmentioning
confidence: 99%
“…A variety of associated factors has been identified including long duration of PD therapy, number of peritonitis episodes, use of beta-adrenergic blocking agents and chronic irritation due to acetate-containing dialysate [ 1 ]. It has been reported that patients with EPS may improve after renal transplantation or with immunosuppressive therapy alone, although the authors of a recent anecdotal case report have questioned the role of immunosuppressive therapy in EPS after transplantation [ 2 ].…”
Section: Introductionmentioning
confidence: 99%