Encapsulating peritoneal sclerosis in children on chronic PD: a survey from the European Paediatric Dialysis Working Group

Shroff, Rukshana; Stefanidis, Constantinos J.; Askiti, Varvara; Edefonti, Alberto; Testa, Sara; Ekı̇m, Mesı̇ha; Kavaz, Aslı; Ariceta, Gema; Bakkaloğlu, Sevcan A.; Fischbach, Michel; Klaus, Guenter; Zurowska, Aleksandra; Hölttä, Tuula; Jankauskienė, Augustina; Vondrák, Karel; Walle, Johan Vande; Schmitt, Claus Peter; Watson, Alan R.

doi:10.1093/ndt/gfs603

Cited by 42 publications

(48 citation statements)

References 35 publications

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“…Encapsulating peritoneal sclerosis (EPS) is a syndrome of gradually increasing obstruction of the small intestine due to formation of massive adhesions between intestinal loops often covered with fibrin capsule. Initially, symptoms suggest intermittent incomplete obstruction, but with time they progress to a complete obstruction requiring a surgical intervention (49). As indicated by Kawanishi et al (49,50) EPS occurs in 2.5% of patients on PD and the incidence increases with the duration of PD.…”

Section: Encapsulating Peritoneal Sclerosismentioning

confidence: 96%

Surgical Management of Complications with Peritoneal Dialysis

Ratajczak

Lange-Ratajczak

Bobkiewicz

et al. 2016

Seminars in Dialysis

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This report reviews the most common surgical interventions and complications of chronic peritoneal dialysis (PD) patients. Based on the current knowledge as well as our experience we detail the role of these surgical procedures. We supplement the reported knowledge in the field with our own experience in this area. The areas discussed include early complications such as surgical wound hemorrhage, bleeding from the catheter, intestinal perforation and urinary bladder perforation, dialysate leakage through the wound, as well as late complications including catheter kinking or occlusion, retention of fluid in the peritoneal recess, hernias and hydrothorax, and encapsulating peritoneal sclerosis. We also briefly cover the surgical aspects of exit-site infection and peritonitis. An understanding by nephrologists of the role for surgical intervention in PD patients will improve their care and outcomes.

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Section: Encapsulating Peritoneal Sclerosismentioning

confidence: 96%

Surgical Management of Complications with Peritoneal Dialysis

Ratajczak

Lange-Ratajczak

Bobkiewicz

et al. 2016

Seminars in Dialysis

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“…Although the pathogenesis still remains unclear, SA‐peritonitis and catheter removal have been reported as possible trigger factors. However, our patient has been on PD for 2.5 years, which is only half as long as the median PD‐vintage found in children with EPS in a recently published study . Moreover, no signs of peritoneal thickening or calcification were detected by radiological investigations, nor was tanning or thickening of the peritoneum reported by the surgeon at catheter removal.…”

Section: Discussionmentioning

confidence: 47%

Fulminant Peritonitis Presumably Caused by Panton‐Valentine Leukocidin‐Positive Staphylococcus aureus in a Girl on Peritoneal Dialysis

et al. 2013

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Peritonitis is a significant complication of peritoneal dialysis (PD) and the most common cause of technique failure. Panton-Valentine leukocidin (PVL), a cytotoxin produced by certain strains of Staphylococcus aureus (SA), causes destruction of neutrophils, and is associated with severe invasive infections. We present a 2.5-year-old girl on PD, who presented suddenly with an unusually fulminant and protracted course of peritonitis. Only a few hours after the onset of clinical signs, septic shock developed. PVL-positive methicillin-sensitive SA (MSSA) was grown and initial empiric antibiotic treatment changed to flucloxacillin and rifampicin in order to minimize toxin production. In spite of adequate antibiotic treatment and PD-catheter removal, recovery was slow. No PD-related peritonitis in children associated with PVL-producing strains have been reported so far and no specific recommendation exists for treatment. We speculate that PVL contributed to the severity and outcome of peritonitis in our patient.

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“…Repeated episodes may not only result in impaired function of the peritoneal membrane as a dialyzing membrane, but they can ultimately result in the serious complication of peritoneal sclerosis (see below), a disorder that not only precludes the use of PD, but one that can result in bowel obstruction, severe malnutrition and death in children and adults [9,10]. Thus, a thorough understanding of factors associated with the risk of experiencing multiple episodes of peritonitis or episodes secondary to unusual organisms, along with an appreciation of the recommended approach to treatment of these infections, is desirable.…”

Section: Introductionmentioning

confidence: 99%

Difficult peritonitis cases in children undergoing chronic peritoneal dialysis: relapsing, repeat, recurrent and zoonotic episodes

Bakkaloğlu

Warady

2014

Pediatr Nephrol

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Despite technological improvements in dialysis connectology and dialysis technique, peritonitis remains the most common and most significant complication of peritoneal dialysis (PD) in children. Most children undergoing chronic PD experience none or only one peritonitis episode, while others have multiple episodes or episodes secondary to unusual organisms. Knowledge of potential risk factors and likely patient outcome is imperative if treatment is to be optimized. In this review we will, in turn, describe episodes of peritonitis that are characterized as either relapsing, recurrent, repeat or zoonosis-related to highlight the clinical issues that are commonly encountered by clinicians treating these infections.

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Encapsulating peritoneal sclerosis in children on chronic PD: a survey from the European Paediatric Dialysis Working Group

Cited by 42 publications

References 35 publications

Surgical Management of Complications with Peritoneal Dialysis

Surgical Management of Complications with Peritoneal Dialysis

Fulminant Peritonitis Presumably Caused by Panton‐Valentine Leukocidin‐Positive Staphylococcus aureus in a Girl on Peritoneal Dialysis

Difficult peritonitis cases in children undergoing chronic peritoneal dialysis: relapsing, repeat, recurrent and zoonotic episodes

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