Encapsulation and Delivery of an Osteosarcoma Stem Cell Active Gallium(III)‐Diflunisal Complex Using Polymeric Micelles

Passeri, Ginevra; Vincent, Ruby; Xiao, Zhiyin; Northcote-Smith, Joshua; Suntharalingam, Kogularamanan

doi:10.1002/cmdc.202200599

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Passeri et al investigated to show that PLGA-PEG polymeric micellar NPs can deliver the OS stem cell active gallium (III)-diflunisal complex into OS cells. This NP formulation showed equivalent or superior sarcosphere toxicity due to increased nuclear DNA damage, cyclooxygenase-2 downregulation, and caspase-dependent apoptosis than other anti-OS drugs such as DOXO, Cis, or Salinomycin [71].…”

Section: Organic Nanocarriersmentioning

confidence: 94%

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Shanmugavadivu,

Lekhavadhani,

Miranda

et al. 2024

Biomed. Mater.

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Osteosarcoma (OS) is a malignant bone neoplasm plagued by poor prognosis. Major treatment strategies include chemotherapy, radiotherapy, and surgery. Chemotherapy to treat OS has severe adverse effects due to systemic toxicity to healthy cells. A possible way to overcome the limitation is to utilize nanotechnology. Nanotherapeutics is an emerging approach in treating OS using nanoparticulate drug delivery systems. Surgical resection of OS leaves a critical bone defect requiring medical intervention. Recently, tissue engineered scaffolds have been reported to provide physical support to bone defects and aid multimodal treatment of OS. These scaffolds loaded with nanoparticulate delivery systems could also actively repress tumor growth and aid new bone formation. The rapid developments in nanotherapeutics and bone tissue engineering have paved the way for improved treatment efficacy for OS-related bone defects. This review focuses on current bifunctional nanomaterials-based tissue engineered scaffolds that use novel approaches such as magnetic hyperthermia, photodynamic therapy, photothermal therapy, bioceramic and polymeric nanotherapeutics against OS. With further optimization and screening, nanomaterials-based tissue engineered scaffolds could meet clinical applications for treating OS patients.

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Section: Organic Nanocarriersmentioning

confidence: 94%

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Shanmugavadivu,

Lekhavadhani,

Miranda

et al. 2024

Biomed. Mater.

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“…For example, PEG–PLGA micelles were used to encapsulate the gallium (III)-diflunisal complex for treating osteosarcoma, and the results showed that the resulting nanoparticle formulations were 5,645 times more potent against osteosarcoma than doxorubicin and cisplatin. The nanoparticle formulation also induced nuclear damage to DNA, downregulation of cyclooxygenase-2, and caspase-driven apoptosis ( Passeri et al, 2023 ).…”

Section: Plga Targeted Nano-drug Delivery Systemsmentioning

confidence: 99%

PLGA-based drug delivery systems in treating bone tumors

Qiu

Liu

2023

Front. Bioeng. Biotechnol.

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Bone tumor has become a common disease that endangers human health. Surgical resection of bone tumors not only causes biomechanical defects of bone but also destroys the continuity and integrity of bone and cannot completely remove the local tumor cells. The remaining tumor cells in the lesion bring a hidden danger of local recurrence. To improve the chemotherapeutic effect and effectively clear tumor cells, traditional systemic chemotherapy often requires higher doses, and high doses of chemotherapeutic drugs inevitably cause a series of systemic toxic side effects, often intolerable to patients. PLGA-based drug delivery systems, such as nano delivery systems and scaffold-based local delivery systems, can help eliminate tumors and promote bone regeneration and therefore have more significant potential for application in bone tumor treatment. In this review, we summarize the research progress of PLGA nano drug delivery systems and PLGA scaffold-based local delivery systems in bone tumor treatment applications, expecting to provide a theoretical basis for developing novel bone tumor treatment strategies.

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Modulating the Anticancer Activity of Square‐Planar Platinum (II) Complex by Its Chelated Diphosphine

Li,

Hou,

Xiao

et al. 2024

Applied Organom Chemis

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This work reports the preparations and anticancer activities of a set of platinum (II) complexes. Two types of bidentate ligands, azadiphosphine (PNP) and diphosphine (PP), were applied to afford different kinds of platinum centers, the homoleptic complexes, [Pt (PNP)2]2+ (1 and 2) and [Pt (PP)2]2+ (4), and the hybrid complex, [Pt (PNP)(PP)]2+ (3). All these complexes are characterized by various analytical techniques, and their structures were validated using single‐crystal X‐ray diffraction analysis. Notably, the stability of the complexes 1–4 is differentiated both in phosphate‐buffered saline (PBS) and in the culture media (RPMI‐1640), relative to the type of coordinated diphosphine ligands, specifically, the more PNP ligands, the less stability. The bite angles of P‐Pt‐P bonds in 1–4 would be reliant on their stability, so that complexes 1 and 2 with small bite angles tend to be labile. A mechanistic understanding on the decomposition of 2 is proposed with the aid of mass analysis. As a result, their anticancer activities should be also associated with their stability so that the chelated ligands, with more PNP ligands, lead to more cytotoxicity. Mechanistically, the poisonous platinum (II) derivatives of complex 2 should interact with the nucleus DNA, whereas the intact complex 4 is not traceable, confirming from a γ‐H2AX‐related immunofluorescence staining kit. Additionally, complex 2 exhibits severe toxicity toward several cancer cells as well as a normal cell. Furthermore, complex 2 has inhibited the formation and viability of three‐dimensional T24 mammospheres, reminding it of a promising candidate for anticancer treatments. Overall, the present work provides a way for the systematic investigation to elucidate how a bidentate diphosphine ligand modulates the stability and the anticancer activities of the corresponding square‐planner platinum (II) complex.

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Encapsulation and Delivery of an Osteosarcoma Stem Cell Active Gallium(III)‐Diflunisal Complex Using Polymeric Micelles

Cited by 3 publications

References 37 publications

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

PLGA-based drug delivery systems in treating bone tumors

Modulating the Anticancer Activity of Square‐Planar Platinum (II) Complex by Its Chelated Diphosphine

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