Encapsulation behavior of curcumin in heteroprotein complex coacervates and precipitates fabricated from β-conglycinin and lysozyme

Zheng, Jiabao; Gao, Qing; Ge, Ge; Sun, Weizheng; Meeren, Paul Van der; Zhao, Ming

doi:10.1016/j.foodhyd.2022.107964

Cited by 8 publications

(4 citation statements)

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“…Some researchers have proposed that the stability of bioactive molecules in liquid coacervates may be significantly better than that of amorphous solid precipitates because solid precipitates do not have micron-scale spherical domains (Figure 9B). [145,167] Interestingly, in cells, the transition of membraneless organelles from the liquid to solid state is also associated with a loss of functionality. However, the relationship between the phase state of complex condensates and the stability of bioactive molecules still needs more confirmation.…”

Section: Encapsulation Of Bioactive Ingredientsmentioning

confidence: 99%

“…Reproduced with permission from Zheng et al. [ 145 ] (C) Protein–polysaccharide solid precipitates capture the probiotics in a loose gel network, and the probiotics are interspersed between the network structures. Reproduced with permission from Bosnea et al.…”

Section: Applicationsmentioning

confidence: 99%

“…Reproduced with permission from Kübelbeck et al [144] (B) The ability of β-conglycinin-lysozyme coacervates to protect curcumin from chemical degradation in aqueous environments was significantly ahead of precipitates. Reproduced with permission from Zheng et al [145] (C) Protein-polysaccharide solid precipitates capture the probiotics in a loose gel network, and the probiotics are interspersed between the network structures. Reproduced with permission from Bosnea et al and Mao et al [146,147] In contrast, liquid coacervates can trap probiotic cells in tight spherical droplets.…”

Section: Enzyme Immobilization and Protein Encapsulationmentioning

confidence: 99%

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New insights into protein–polysaccharide complex coacervation: Dynamics, molecular parameters, and applications

Zheng,

Van der Meeren,

Sun

2023

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For more than a decade, the discovery of liquid–liquid phase separation within living organisms has prompted colloid scientists to understand the connection between coacervate functionality, phase behavior, and dynamics at a multidisciplinary level. Although the protein–polysaccharide was the first system in which the coacervation phenomenon was discovered and is widely used in food systems, the phase state and relaxation dynamics of protein–polysaccharide complex coacervates (PPCC) have rarely been discussed previously. Consequently, this review aims to unravel the relationship between PPCC dynamics, thermodynamics, molecular architecture, applications, and phase states in past studies. Looking ahead, solving the way molecular architecture spreads to macro‐functionality, that is, establishing the relationship between molecular architecture–dynamics–application, will catalyze novel advancements in PPCC research within the field of foods and biomaterials.

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Section: Encapsulation Of Bioactive Ingredientsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Enzyme Immobilization and Protein Encapsulationmentioning

confidence: 99%

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New insights into protein–polysaccharide complex coacervation: Dynamics, molecular parameters, and applications

Zheng,

Van der Meeren,

Sun

2023

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“…5,6 However, the key requirement for colon-targeting delivery is that curcumin should be protected in the stomach and small intestine before reaching the colon. 5,7 To improve the stability of curcumin in the gastrointestinal tract, various types of carriers such as emulsions, 8 liposomes, 9 protein nanoparticles, 10 complex coacervates, 11 protein nanotubes, 12 filled hydrogel beads, 13 solid lipid nanoparticles, 14 and micelles 15 have been developed. In this regard, scientists have focused on contemporary materials such as proso millet protein, 16 sunflower protein isolate, 17 rapeseed cruciferin, 18 and insect proteins 19 to develop curcumin-loaded delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Design of glucono‐δ‐lactone‐induced pinto bean protein isolate/κ‐carrageenan mixed gels with various microstructures: fabrication, characterization, and release behavior

et al. 2022

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BACKGROUND Protein gels are used for different purposes, such as providing good texture, serving as fat replacers, and enhancing the nutritional and functional characteristics of foods. They can also deliver controlled release agents for sensitive drugs. The objective of this study was to investigate the impact of κ‐carrageenan (kcr) concentration (0, 1.5, 3, and 4.5 mg g−1) on the morphological and physicochemical properties and release behavior of glucono‐δ‐lactone (GDL)‐induced pinto bean protein aggregate (PBA) gels. RESULTS When κ‐carrageenan concentration increased from 0 to 1.5 and 3 mg.g−1, the firmness of the samples increased significantly, by 2.04 and 3.7 fold, respectively (P < 0.05). A compact and homogenous network with considerable strength and maximum water‐holding capacity (97.52 ± 1.17%) was obtained with the addition of 3 mg g−1 κ‐carrageenan to the gel system. Further increasing the κ‐carrageenan concentration to 4.5 mg g−1 produced a coarse gel structure with higher storage modulus (G′), firmness (6.30‐fold), thermal stability, and entrapment efficiency (85.6%). Depending on the κ‐carrageenan concentration, various microstructures from protein continuous phase to κ‐carrageenan continuous phase were observed. The release test indicated that 70.25% of the loaded curcumin was released in the simulated gastrointestinal tract for pure PBA gels. In contrast, for binary gels containing 4.5 mg g−1 κ‐carrageenan, curcumin was protected in the upper gastrointestinal tract, and 64.45% of loaded curcumin was delivered to the colon. CONCLUSION Our study showed that κ‐carrageenan/PBA gels had high entrapment efficiency and could protect curcumin in the upper gastrointestinal tract. The hydrogels are therefore very valuable for colon‐targeting delivery purposes. © 2022 Society of Chemical Industry.

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Curcumin microcapsule-based drug delivery as cancer therapeutics

Moosavian,

Salehabadi,

Sahebkar

2024

Curcumin-Based Nanomedicines as Cancer Therapeutics

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Encapsulation behavior of curcumin in heteroprotein complex coacervates and precipitates fabricated from β-conglycinin and lysozyme

Cited by 8 publications

References 51 publications

New insights into protein–polysaccharide complex coacervation: Dynamics, molecular parameters, and applications

New insights into protein–polysaccharide complex coacervation: Dynamics, molecular parameters, and applications

Design of glucono‐δ‐lactone‐induced pinto bean protein isolate/κ‐carrageenan mixed gels with various microstructures: fabrication, characterization, and release behavior

Curcumin microcapsule-based drug delivery as cancer therapeutics

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