Encapsulation efficiency and controlled release characteristics of crosslinked polyacrylamide particles

Electric field assisted transdermal drug delivery from salicylic acid-loaded polyacrylamide hydrogels

“…The melting temperature (T m ) of PAAM is 231°C, consistent with a previous study (Sairam et al, 2006). However, the T m of PAAM in SA-loaded PAAM occurs at 225°C, suggesting that SA possibly interacts with the PAAM hydrogel through hydrogen bonding between the hydroxyl groups of the SA and the amine groups of the PAAM hydrogel.…”

“…The release rate is slower with the samples with a higher cross-linking ratio, apparently due to the smaller pore size (Sairam et al, 2006), as shown in the SEM micrographs of Figure 1. In addition, the smaller percent swelling may further hinder the amount of salicylic acid released from the hydrogel.…”

Additive Manufacturing of PE/Fluorouracil Waffles for Implantable Drug Delivery in Bone Cancer Treatment

“…The initial concentration of FU released from the PE/FU waffles may provide a high initial concentration of the drug locally in the cancer cells following implantation. The subsequent controlled release allows for sustained levels of the chemotherapeutic agent at the cancer site [35,36]. These results demonstrate the potential use of PE/FU tables for treating cancer cells since FU molecules and aggregates have affinity for cancer cells and may accumulate preferentially within tumors through the delivery of the implanted waffle.…”

3D printing of PCL/Fluorouracil tablets by selective laser sintering: Properties of implantable drug delivery for cartilage cancer treatment

“…The initial amount of FU released by the sintered PCL/FU tablets is a desirable profile to provide a high initial concentration of the drug locally in the cancer cells following implantation. The slow and controlled release of the drug subsequently will allow for sustained levels of the chemotherapeutic agent at the cancer site [34,35]. This may be beneficial therapeutically since FU molecules and small particulates are capable of preferentially accumulating within tumors via the delivery of the implanted tablet.…”