Encapsulation of actives for sustained release

Trojer, Markus Andersson; Nordstierna, Lars; Nordin, Matias; Nydén, Magnus; Holmberg, Krister

doi:10.1039/c3cp52686k

Cited by 86 publications

(22 citation statements)

References 160 publications

(233 reference statements)

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“…The release rate is defined by at least one of the following mechanism: (1) diffusion-based release, (2) degradation-based release, and (3) affinity-based release, and. Zero-order release kinetics is usually preferred since a steady drug concentration is maintained between the minimum effective concentration (MEC) and maximum toxic concentration (MTC) [219]. Although a zero-order release profile is desired, most drug delivery systems show a thriphasic release profile.…”

Section: Passive Drug Delivery Systemsmentioning

confidence: 99%

Drug delivery systems and materials for wound healing applications

Saghazadeh

Rinoldi

Schot

et al. 2018

Advanced Drug Delivery Reviews

619

434

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Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted.

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Section: Passive Drug Delivery Systemsmentioning

confidence: 99%

Drug delivery systems and materials for wound healing applications

Saghazadeh

Rinoldi

Schot

et al. 2018

Advanced Drug Delivery Reviews

619

434

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“…It should be noted that, unfortunately, the zero‐order kinetic results are not always accurate in the release process, and just in the initial period of the release process, the predicted profile is acceptable (Manca & Rovaglio, 2003). Andersson Trojer, Nordstierna, Nordin, Nyden, and Holmberg (2013) reported that only in the case of a monodisperse carrier system (a shell and core) with the steady release, the true zero‐order kinetics was achieved. They claimed using the term “zero order" is one of the most frequent mistakes in controlled release literature.…”

Section: Empirical and Semiempirical Release Modelsmentioning

confidence: 99%

Modeling the release of food bioactive ingredients from carriers/nanocarriers by the empirical, semiempirical, and mechanistic models

Malekjani

Jafari

2020

Comp Rev Food Sci Food Safe

139

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The encapsulation process has been utilized in the field of food technology to enhance the technofunctional properties of food products and the delivery of nutraceutical ingredients via food into the human body. The latter application is very similar to drug delivery systems. The inherent sophisticated nature of release mechanisms requires the utilization of mathematical equations and statistics to predict the release behavior during the time. The science of mathematical modeling of controlled release has gained a tremendous advancement in drug delivery in recent years. Many of these modeling methods could be transferred to food. In order to develop and design enhanced food controlled/targeted bioactive release systems, understanding of the underlying physiological and chemical processes, mechanisms, and principles of release and applying the knowledge gained in the pharmaceutical field to food products is a big challenge. Ideally, by using an appropriate mathematical model, the formulation parameters could be predicted to achieve a specific release behavior. So, designing new products could be optimized. Many papers are dealing with encapsulation approaches and evaluation of the impact of process and the utilized system on release characteristics of encapsulated food bioactives, but still, there is no deep insight into the mathematical release modeling of encapsulated food materials. In this study, information gained from the pharmaceutical field is collected and discussed to investigate the probable application in the food industry.

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“…The short solvent evaporation group exhibited a single core-shell architecture (Figure 2C), whereas the long solvent evaporation groups had a more prominent multicore-shell (multicore) structure (Figure 2G). 44 Interestingly, the multicore structures achieved with the long solvent evaporation seemed to aggregate in close proximity to the MP center as well as at the edges of the MPs (Figure 2G). The average MP diameters were significantly different (p<0.01) at 32.8±17.4 μm and 80.0±32.5 μm for the short and long solvent evaporation groups, respectively.…”

Section: Resultsmentioning

confidence: 97%

Tunable delayed controlled release profile from layered polymeric microparticles

et al. 2017

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Composite microparticles (MPs) with layered architecture, engineered from poly(L-lactic acid) (PLLA) and poly(D,L-lactic-co-glycolic acid) (PLGA), are promising devices for achieving the delayed release of proteins. Here, we build on a water-in-oil-in-oil-in-water emulsion method of fabricating layered MPs with an emphasis on modulating the delay period of the protein release profile. Particle hardening parameters (i.e. polymer precipitation rate and total hardening time) following water-in-oil-in-oil-in-water emulsions are known to affect MP structure such as the core/shell material and cargo localization. We demonstrate that layered MPs fabricated with two different solvent evaporation parameters not only alter polymer and protein distribution within the hardened MPs, but also affect their protein release profiles. Secondly, we hypothesize that ethanol (EtOH), a semi-polar solvent miscible in both the solvent (dichloromethane; DCM) and non-solvent aqueous phases, likely alters DCM and water flux from the dispersed oil phase. The results reveal that EtOH affects protein distribution within MPs, and may also influence MP structural properties such as porosity and polymer distribution. To our knowledge, we are the first to demonstrate EtOH as a means for modulating critical release parameters from protein-loaded, layered PLGA/PLLA MPs. Throughout all the groups in the study, we achieved differential delay periods (between 0 – 30 days after an initial burst release) and total protein release periods (~30 – >58 days) as a function of solvent evaporation parameters and EtOH content. The layered MPs proposed in the study potentially have wide-reaching applications in tissue engineering for delayed and sequential protein release.

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Encapsulation of actives for sustained release

Cited by 86 publications

References 160 publications

Drug delivery systems and materials for wound healing applications

Drug delivery systems and materials for wound healing applications

Modeling the release of food bioactive ingredients from carriers/nanocarriers by the empirical, semiempirical, and mechanistic models

Tunable delayed controlled release profile from layered polymeric microparticles

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