Encapsulation of Au(III) Complex Using Lactoferrin Nanoparticles to Combat Glioma

Abstract

Metal-based drugs have been used for decades to treat solid cancers; however, these drugs have no significant therapeutic effect on glioma because they cannot effectively cross the blood–brain barrier (BBB). To develop a novel metal-based agent that can cross the BBB to target glioma, we synthesized an Au complex (C2) with remarkable glioma cytotoxicity and fabricated lactoferrin (LF)-C2 nanoparticles (LF-C2 NPs) as a novel therapy. We confirmed that C2 kills glioma cells by inducing apoptosis and autophagic death. The LF-C2 NPs cross the BBB, inhibit glioma growth, and selectively accumulate in the tumor tissue, significantly decreasing the side effects of C2. This study provides a novel strategy for applying metal-based agents to targeted therapy for glioma.

Interaction of Au(iii) with amino acids: a vade mecum for medicinal chemistry and nanotechnology

“…[10][11][12][13][14] AuNCs are among the most promising theranostic agents for applications in nanomedicine. 10,[26][27][28][29][30][31][32][33] Interaction of Au(III) with proteins may also be useful for (i) developing innovative photodynamic and photoactivated therapies; 34,35 (ii) radiotherapeutic purposes, since Au possesses two ß-emitting isotopes, 198 Au and 199 Au, 9 and the proteins can be used as carriers; 36 (iii) catalysis and metalmediated transformations in biological systems. 37 The increasing interest in interactions between Au(III) and amino acids/peptides/proteins spurred a thorough investigation of the chemical mechanism governing their binding.…”

“…Interaction of Au( iii ) with proteins may also be useful for (i) developing innovative photodynamic and photoactivated therapies; 34,35 (ii) radiotherapeutic purposes, since Au possesses two β-emitting isotopes, 198 Au and 199 Au, 9 and the proteins can be used as carriers; 36 (iii) catalysis and metal-mediated transformations in biological systems. 37…”

Synthesis, Characterization, and Biological Properties of the Copper(II) Complexes with Novel Ligand: N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide

“…The identification of potential new antibactericidal/antifungicidal drugs with increased efficiency based on coordinative combinations is in vogue, their stake would be low side effects; and overcoming the resistance achieved by current drugs [19][20][21][22][23][24].…”