Encapsulation of curcumin into layered double hydroxides improve their anticancer and antiparasitic activity

Abstract

Objectives Curcumin (CUR) has well-known activity against cancer cells and parasites; however, its applications are limited since this is an unstable molecule, which may suffer degradation by light and temperature, also, the low water solubility reduce its bioavailability. Layered double hydroxides (LDH) are well-known materials owing to the excellent anion exchange capacity, good biocompatibility and low toxicity. Methods Layered double hydroxides nanoparticles prepared with zinc and magnesium cations were used as a vehicle for CUR in Caco-2, Giardia lamblia and Entamoeba histolytica cultures. The physicochemical properties of Mg-LDH-CUR and Zn-LDH-CUR were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrometry (FTIR) and X-ray powder diffraction (XRD). Additionally, the load efficiency, release profiles and photostability of CUR were quantified by high-performance liquid chromatography (HPLC) and UV-Vis spectrometry. Then, Mg-LDH-CUR and Zn-LDH-CUR were tested on Caco-2, G. lamblia and E. histolytica cultures. Key findings The experiments demonstrated that Zn-LDH-CUR protects better against photodegradation by UV light, while Mg-LDH-CUR showed increased toxicity against Caco-2 cell, G. lamblia and E. histolytica, in comparison with free CUR.Conclusions Layered double hydroxides are good vehicles to improve stability, resistance to degradation of CUR, also they are useful to improve solubility, provide a controlled release and improve the cytotoxic activity. Additionally, it was shown that the composition of the M +2 cation of LDH affects its properties and structure and that this directly influences its biological activity. The findings are important to select the composition of the encapsulation vehicle for a specific activity. Research PaperEncapsulation of curcumin in LDH as antiparasitic Filiberto Guti errez-Guti errez et al.

Utility of Intravenous Curcumin Nanodelivery Systems for Improving In Vivo Pharmacokinetics and Anticancer Pharmacodynamics

“…Fast biliary clearance of free curcumin after intravenous injection, evidenced by the detection of curcumin in bile as early as 5 min after intravenous administration, was observed in rats . Finally, free curcumin is more amenable to degradation in plasma than nanoencapsulated curcumin, where the excipient encapsulating curcumin offers protection chemically and/or sterically, ,, culminating in comparatively lower retrieval of free curcumin from plasma. Hitherto no studies elaborately assessed the degradation rate of curcumin in a plasma matrix, and therefore the extent of this effect on the PK of curcumin is still unknown.…”

A Novel Green Approach to Synthesize Curcuminoid-Layered Double Hydroxide Nanohybrids: Adroit Biomaterials for Future Antimicrobial Applications

“…8 Out of the many potential natural drug molecules that could be stabilized within the layers of LDH and thus used as controlled release drug formulations, curcuminoid intercalated LDH has shown promising applications in the cosmeceutical and pharmaceutical industry. 9 Curcuminoids, a polyphenolic compound extracted from the rhizome of C. longa, have numerous functional properties such as antioxidant, antiinflammatory, and skin lightening agents, without side effects. 10 However, poor water solubility and stability of curcuminoids due to photodegradation and enzymatic degradation have limited their practical applications.…”

“…Out of the many potential natural drug molecules that could be stabilized within the layers of LDH and thus used as controlled release drug formulations, curcuminoid intercalated LDH has shown promising applications in the cosmeceutical and pharmaceutical industry . Curcuminoids, a polyphenolic compound extracted from the rhizome of C.…”

Layered Double Hydroxides-Loaded Sorafenib Inhibit Hepatic Stellate Cells Proliferation and Activation In Vitro and Reduce Fibrosis In Vivo

“…In addition, LDHs are injectable and suitable for intravenous administration. Last but not least, the artificial synthesis of LDHs is relatively cheap and eco-friendly, suggesting that LDHs have great commercial value in the field of drug delivery ( Zhu et al, 2016 ; da Costa Fernandes et al, 2019 ; Gutierrez-Gutierrez et al, 2020 ). The current study aimed to load sorafenib into LDHs, hoping to develop an actively targeted nanomedicine for liver-fibrosis therapy and improve the bioavailability and efficiency of sorafenib.…”