Encapsulation of edible active compounds using supercritical fluids

Varona, Salima; Martín, Ángel; Cocero, Marı́a José

doi:10.1002/9781118946893.ch2

Cited by 3 publications

(3 citation statements)

References 70 publications

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“…Several techniques of drug encapsulation/formulation in polymers have been reported, such as spray drying, emulsification, and extrusion 9 . The supercritical antisolvent system (SAS) is a technique that produces microparticles and nanoparticles for several diverse application such as pharmaceuticals, cosmetics, and pigments 10 .…”

Section: Introductionmentioning

confidence: 99%

Single step encapsulation process of ivermectin in biocompatible polymer using a supercritical antisolvent system process

Valarini

Cardoso

Souza

et al. 2021

Asia-Pacific J Chem Eng

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This paper reports the production of ivermectin (IVM)‐encapsulated lecithin/poly (methyl methacrylate) (PMMA) nanoparticles via supercritical antisolvent system (SAS). Of a total of nine formulations, experimental condition R7 containing 10% lecithin relative to polymer (PMMA) resulted in the smallest average experimental particle diameter (dexp), more stable surface charges and high IVM encapsulation efficiency (75.9 ± 2.5%). Nanoparticles were morphologically, thermally, and conformationally characterized using scanning electron microscopy (SEM), thermogravimetric analysis/thermogravimetric derivative (TGA/DTG), and Fourier transform infrared–attenuated total reflectance (FTIR/ATR) techniques. In vitro release test showed that the drug has a controlled release of approximately 110 h. Peppas–Sahlin model (R2 = 0.99) was able to describe the diffusion of the drug correctly. Cytotoxicity analysis showed high compatibility of nanoparticles with epithelial cells, fibroblasts, and macrophages. Population balance equation was used to determine kinetic parameters from experimental data of average particle diameter. Synthesized nanoparticles showed high solution stability, good encapsulation capacity, and showed no adverse effects on cell viability, indicating their high potential as a new IVM carrier system for veterinary medicine and human applications.

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Section: Introductionmentioning

confidence: 99%

Single step encapsulation process of ivermectin in biocompatible polymer using a supercritical antisolvent system process

Valarini

Cardoso

Souza

et al. 2021

Asia-Pacific J Chem Eng

View full text Add to dashboard Cite

show abstract

“…However, its main disadvantage is the high investment cost because of the high-pressure variations applied. The encapsulation process by supercritical fluid technology can be classified according to the role that the supercritical fluid plays on it: solvent, anti-solvent and co-solvent, or solute (Varona, Martín, & Cocero, 2016). The main processes for anthocyanins encapsulation with their classifications are described below.…”

Section: Supercritical Fluid Technologymentioning

confidence: 99%

“…In this process, the target compound and the wall material are dissolved in a liquid solvent and are atomized together with the supercritical fluid. Then, the supercritical fluid acts as an antisolvent through the decrease in the solubility of the solute in the mixture, which results in supersaturation and the formation of nano-or microparticles (Varona et al, 2016). This process is attractive due to attaining high loading efficiencies with controlled particle size and distribution.…”

Section: Ress (Rapid Expansion Of Supercritical Solutionsmentioning

confidence: 99%

Extração, bioacessibilidade e encapsulação de compostos fenólicos da casca da jabuticaba

Gadioli Tarone.

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Jabuticaba (Myrciaria jabuticaba (Vell.) Berg) is a typical Brazilian fruit, source of phenolic compounds and anthocyanins mainly concentrated in the peel. The low stability of these compounds requires new extraction and encapsulation techniques to improve and expand its applicability in the food and pharmaceutical industry. This thesis aimed to find the best combination of the studied variables for better extraction of phenolic compounds from jabuticaba peel powder using high-intensity ultrasoundassisted extraction and investigate the effects of fructooligosaccharides (FOS) and inulin with different degrees of polymerization (DP) on the properties of pectin-based structured systems and their performance as encapsulating matrices for the optimized extract. The effects of ultrasound intensity (1.1, 3.7, 7.3, and 13.0 W/cm 2 ) and solvent composition concerning water/ethanol ratio (0, 25, 50, 75, and 100 g water/100 g) were examined using a full factorial experimental design (4 × 5), and the maximum recovery of bioactive compounds was at an ultrasound intensity of 3.7 W/cm² and 50 g water/100 g, demonstrating that the interaction between the parameters studied has a strong influence on the extraction efficiency of the groups of compounds studied and on their antioxidant potential. The identification and quantification of the phenolic compounds present in the optimized extract were made by UPLC/DAD/ESI-MS n analysis, and 58 phenolic compounds were tentatively identified. The antioxidant capacity against lipid oxidation and the bioaccessibility of the anthocyanins present in the extract were evaluated in vitro by a gastrointestinal digestion model concerning a Western-type diet.Both extract concentrations used (1 and 5 mg/mL) were able to inhibit lipid oxidation, largely decreasing the formation of the analyzed lipid oxidation markers (conjugated dienes and 4-hydroxy-2-nonenal). The assays also showed high bioaccessibility of anthocyanins, especially when the highest concentration was evaluated, however, bioaccessible delphinidin-3-O-glucoside was not detected at the lowest concentration.The combination of pectin and inulin with different DP demonstrated to be a promising encapsulating system for jabuticaba peel polyphenols with potential use as functional and structural food ingredient. The pectin-based encapsulating system and the pectinbased encapsulating system with the addition of inulin with DP ≥ 23 were the most efficient in protecting the jabuticaba peel extract, exhibiting the best results for the stability of the antioxidant capacity.

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Recent advancement in protected delivery methods for carotenoid: a smart choice in modern nutraceutical formulation concept

Bera

Mitra

Singh

2023

Biotechnology and Genetic Engineering Reviews

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Encapsulation of edible active compounds using supercritical fluids

Cited by 3 publications

References 70 publications

Single step encapsulation process of ivermectin in biocompatible polymer using a supercritical antisolvent system process

Single step encapsulation process of ivermectin in biocompatible polymer using a supercritical antisolvent system process

Extração, bioacessibilidade e encapsulação de compostos fenólicos da casca da jabuticaba

Recent advancement in protected delivery methods for carotenoid: a smart choice in modern nutraceutical formulation concept

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