Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis

Abstract

Na2B12I12 has many of the properties desired by an X-ray contrast agent but is lethal at the concentrations needed for medical imaging. We demonstrate here that PBS solutions with >...

Large anion binding in water

“…160,161 Hollow and Johnstone have recently reported that the complexation of the iodinated cluster with a permethylated γ-CD derivative prevents hemolysis, due to complexation. 160 The authors also reported the XRD structure of the B 12 I 12 2− •γ-CD complex which bears close similarity to that of B 12 Br 12 2−…”

“…The largest dodecaborate anion, B 12 I 12 2− , is also a promising X-ray contrast agent for medical diagnostics (owing to the heavy-atom content) but it is known to induce hemolysis at high mM concentrations. 160,161 Hollow and Johnstone have recently reported that the complexation of the iodinated cluster with a permethylated γ-CD derivative prevents hemolysis, due to complexation. 160 The authors also reported the XRD structure of the B 12 I 12 2− ·γ-CD complex which bears close similarity to that of B 12 Br 12 2− ·γ-CD (Fig.…”

Superchaotropic Nano‐ion Binding as a Gelation Motif in Cellulose Ether Solutions

“…Additionally, the binding sites in HPC are rather undefined, while in γ‐CD the well‐defined cavity allows for a good size‐match [9] with SiW further facilitating binding. Notably, binding affinities to γ‐CD and functionalized Hydroxypropγl‐CD (the macrocyclic equivalent to HPC) are expected to be similar, [36] which points at the insignificance of chemical differences between HPC and γ‐CD for the binding in comparison to their topographical differences.…”

Metallacarborane Cluster Anions of the Cobalt Bisdicarbollide-Type as Chaotropic Carriers for Transmembrane and Intracellular Delivery of Cationic Peptides

“…Boron-containing compounds have application potential in pharmaceutical chemistry, − with boron neutron capture therapy being the most prominent example . Recently, a new cell-biological as well as medicinal-chemical application line has been documented for icosahedral dodecaborates B 12 X 12 2– (X = H, Cl, Br, and I; Figure a), because their superchaotropic ionic character − enables their use as broadband membrane carriers, that is, they enable cellular uptake of a wide range of otherwise impermeable hydrophilic molecules, including amino acids, neurotransmitters, peptides, and drugs. , This, combined with their chemical inertness, ,− high water solubility, ,, and high biocompatibility, ,,,,, defines a new research area in chaotropic inorganic cluster chemistry. Accordingly, it is of interest to investigate how variations in the boron cluster structure and topology affect their chaotropic character and, thus, their potential membrane carrier activity.…”