Encapsulation of low molecular weight heparins: Influence on the anti-Xa/anti-IIa ratio

PEG–PLGA based large porous particles for pulmonary delivery of a highly soluble drug, low molecular weight heparin

“…Over the past few decades, poly(lactide-co-glycolic acid) (PLGA) microparticles have been used as carriers for delivery of drugs of varying chemical makeup and to achieve controlled release property after parenteral [1], oral [2] and pulmonary administration [3,4].show Edwards and others have reported that prolonged release inhalable formulations of various drugs can be developed by engineering the size and density of PLGA based particles [5,6]. PLGA particles with reduced density of b 0.4 g/ml and geometric diameter > 5 μm can address many limitations associated with conventional nonporous inhalable particles of unit density (1 g/ml).…”

“…Currently, LMWHs are administered by subcutaneous injection for the treatment of deep vein thrombosis and pulmonary embolism [16]. To develop noninvasive drug delivery systems for LMWHs, we and others have used PLGA microparticles to deliver the drug via the pulmonary, nasal and oral routes [2,[17][18][19][20]. However, because of its hydrophilic nature, drug payload was minimal.…”

Photocatalytic Degradation of Chlorophenol Compounds using Poly Aromatic Star Copolymer

“…These results were caused by the low initial concentration of pentachlorophenol due to its relatively low solubility. The 2,4-dichlorophenol was more bound by the P-PSD than the other two chlorophenols due to its relatively low molecular weight and density, which were considered the reasons for it easy encapsulation, as it would have a greater chance to contact with the P-PSD (Reignier et al 2003;Javot et al 2009). …”

Enoxaparin-immobilized poly(ε-caprolactone)- based nanogels for sustained drug delivery systems

“…Among different dosage forms, nanoparticles have been identified as a novel class of matrices possessing a great potential as drug carrier [8,9]. Heparin, a highly sulfated glycosamineglycan, is widely used as an injectable anticoagulant, and has the highest charge density of any known biological molecule [10]. It is used clinically to minimize thrombus formation on artificial surfaces.…”