Encapsulation of natural drug gentiopicroside into zinc based Zeolitic Imidazolate Frameworks (ZIF-8): In-vitro drug release and improved antibacterial activity

Self-Charging, Breathable, and Antibacterial Poly(lactic acid) Nanofibrous Air Filters by Surface Engineering of Ultrasmall Electroactive Nanohybrids

“…We further analyzed the excellent antibacterial activity of PLA/BZ10 (Figure b), contributing from the following synergistic mechanisms: (1) the high porosity and high surface energy of BTO@ZIF-8 caused bacteria to be firmly adsorbed on the NFM surface, which was advantageous for Zn 2+ and 2-MIM slowly released by BTO@ZIF-8 to cause oxidative stress and damage bacterial organic matters; (2) under light irradiation, the charge separation process of BTO@ZIF-8 happened, activating Zn 2+ to Zn + , which reacts with O 2 through reduction–oxidation reaction, producing ROS. Additionally, BTO@ZIF-8 formed surface piezoelectric potential under vibration stimulation and produced ROS .…”

Facile encapsulation of glabridin in Zeolitic Imidazolate Framework-8 (ZIF- 8): Characterization, antibacterial activity and in-vitro drug release

“…The Glab@ZIF-8 was synthesized through the one-pot method [18,19]. In detail, 1 g of Zn(NO 3 ) 2 •6H 2 O and 2.5 g of 2-methylimidazole were dissolved in 20 mL of Milli-Q water, separately, and were stirred at room temperature for 30 minutes to obtain a clear solutions.…”

“…On the other hand, it is incompatible with physiological pH; for example, it remains unstable under basic conditions (pH > 7), the structures of its degradation products are yet unknown [15], and it remains stable only at neutral pH [15]; moreover, its further pharmacological value is lacking [17]. However, such limitations to glabridin could be handled through encapsulation technology [17][18][19][20], as it is widely considered a leading alternative for protecting, stabilizing and delivering bioactive drugs with the aid of pH-responsive media [18]. Furthermore, the shelf life of bioactive natural drugs can be improved at normal temperatures, and their decomposition by environmental factors can be limited if they can be loaded into advanced nanomaterials, i.e., metal-organic frameworks [21], by adopting novel nanotechnology strategies.…”

“…ZIF-8, in view of the above qualities, has been widely studied as a potentially useful material for the encapsulation and pH-responsive shipment of various medicines [18], nucleic acids, uorescein [34], photothermal agents [35,36] and active proteins [37] owing to its certain shortcomings. Furthermore, several previous recent studies have reported the encapsulation of curcumin [20], physcion [18] and gentiopicroside [19] into ZIF-8 to improve drug stability and pharmacokinetics and to observe enhanced antibacterial activity.…”

pH‐Responsive Bimetallic MOFs ZIF‐8@ZIF‐67 for Enhanced Antibacterial Activity

“…Metal-organic frameworks (MOFs) represent a significant class of inorganic-organic hybrid crystalline porous materials formed by coordination bonds between organic ligands and metal ions. [4] In comparison to conventional nanocarriers such as liposomes, polymers, and inorganic nanoparticles, MOFs offer additional advantages such as tunable size and structure, ease of surface functionalization, [5] as well as the ability to address drug instability, systemic side effects, and toxicity concerns. [6] Therefore, efforts have been made to develop stimulusresponsive systems based on MOFs and MOFs composites for drug delivery purposes.…”