Encapsulation of Oil Phases with Different Compositions into a Shell Composed of Nanoparticles of Natural Hydrothermal Silica and Polyelectrolyte Layers

Паламарчук, К. В.; Букреева, Т. В.; Kalashnikova, Irina; Zelenkov, Valery N.; Потапов, В. В.

doi:10.1134/s1061933x21020083

Cited by 6 publications

(6 citation statements)

References 15 publications

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“…LbL capsules have been actively studied over the past 20 years due to the broad possibilities for adjusting the thickness, permeability, and biodegradability of their shells [ 32 , 33 ]. However, only a few works have described colloidosomes based on Pickering emulsions modified with multilayer polyelectrolyte shells [ 11 , 34 , 35 ]. It has been shown that additional polymer layers allow the control of the permeability of capsules [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that additional polymer layers allow the control of the permeability of capsules [ 11 ]. Moreover, the polyelectrolyte shell provides an increased stability of colloidosomes, for example, during centrifugation [ 35 ]. However, the above-mentioned papers described colloidosomes in the micrometer size range, with the shells formed by monoparticles [ 11 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers

et al. 2022

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Capsules with shells based on nanoparticles of different nature co-assembled at the interface of liquid phases of emulsion are promising carriers of lipophilic drugs. To obtain such capsules, theoretically using the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory and experimentally using dynamic light-scattering (DLS) and transmission electron microscopy (TEM) methods, the interaction of like-charged silica nanoparticles and detonation nanodiamonds in an aqueous solution was studied and their ratios selected for the formation of submicron-sized colloidosomes. The resulting colloidosomes were modified with additional layers of nanoparticles and polyelectrolytes, applying LbL technology. As a model anti-cancer drug, thymoquinone was loaded into the developed capsules, demonstrating a significant delay of the release as a result of colloidosome surface modification. Fluorescence flow cytometry and confocal laser scanning microscopy showed efficient internalization of the capsules by MCF7 cancer cells. The obtained results demonstrated a high potential for nanomedicine application in the field of the drug-delivery system development.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers

et al. 2022

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“…Nanocapsules of silica or organic–inorganic organosilica are attracting much attention due to their widespread applications in adsorbing materials, nanocontainers, biotechnology, cosmetics, and catalyst, attributing to their high drug loading capability, excellent biocompatibility and easy functionalization 17–20 . There are several general methods have been developed for the preparation of silica or organic–inorganic silica shelled nanocapsules, including the Stöber method, microemulsion templating, hydrothermal synthesis, Pickering stabilization and polymerization‐induced colloidal agglomeration 21–25 . Among them, although different alkoxy silane precursors are used under specific conditions, these methods have some commonalities.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of organosilica nanocapsules encapsulating DCOIT by using the response surface optimization

Liu

Lü

Cheng

et al. 2022

J of Applied Polymer Sci

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Antifouling agent 4, 5‐dichloro‐2‐n‐octyl‐4‐isothiazolin‐3‐one (DCOIT) in a one‐stage process based on the self‐catalytic reaction between methyl trimethoxysilane (MTMS) and 3‐aminopropyl trimethoxysilane (APS) in an aqueous system without any surfactants and catalysts have been developed. The optimal preparation process parameters of organosilica nanocapsules encapsulating DCOIT (DCOIT@SiNC) were determined using response surface methodology (RSM) based on the single‐factor experimental results. The results of RSM optimization showed that 49.51% encapsulation efficiency (EE [%]) would be achieved with a shell–core mass ratio of 5.59:1, a MTMS‐APS mole ratio of 1.52:1, and a reaction temperature of 31°C. DCOIT@SiNC prepared according to the RSM optimal process exhibited a decent uniform sphericity with an average particle diameter of 660.50 nm. The encapsulation was characterized by Fourier‐transform infrared and X‐ray diffraction. The loading efficiency and thermal stability were verified via thermogravimetric analysis. Compared to DCOIT, DCOIT@SiNC had better controlled release performance, and the release kinetics investigated by Riger‐peppas model indicated that the release of DCOIT was diffusion‐controlled.

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“…Oil-core colloidosomes were prepared to address the usual volatility or stability concerns inherent with hydrophobic actives (e.g., flavors, fragrance, antioxidants, vitamins, pesticides, etc. ). − …”

Section: Introductionmentioning

confidence: 99%

“…Such oil-core systems are usually produced from a Pickering-emulsion template, with particles locked together in a robust shell through thermal annealing, layer-by-layer polyelectrolyte deposition, − ionotropic gelation, , cross-linking, − interfacial polymerization, or growing of an additional inorganic , or metallic shell . However, such approaches exhibit certain limitations.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Multicore Colloidosomes: Nanoparticle-Assembled Capsules with Adjustable Size, Internal Structure, and Functionalities for Oil Encapsulation

Brossault

McCoy

Routh

2021

ACS Appl. Mater. Interfaces

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Colloidosomes, also known as Pickering emulsion capsules, have attracted attention for encapsulation of hydrophilic and hydrophobic actives. However, current preparation methods are limited to single core structures and require the use of modified/engineered nanoparticles for forming the shell. Here, we report a fast, simple, and versatile method for producing multi-oil core silica colloidosomes via salt-driven assembly of purely hydrophilic commercial nanoparticles dispersed within an oil-inwater-in-oil (O/W/O) double emulsion template. The internal structure and overall diameter of the capsules can be adjusted by altering the primary and secondary emulsification conditions. With this approach, 7−35 μm diameter multicore colloidosomes containing 0.9−4.2 μm large oil cores were produced. The capsules can easily be functionalized depending on the type of nanoparticles used in the preparation process. Here, metal oxide nanoparticles, such as Fe 3 O 4 , TiO 2 , and ZnO, were successfully incorporated within the structure, conferring specific functional properties (i.e., magnetism and photocatalysis) to the final microcapsules. These capsules can also be ruptured by using ultrasound, enabling easy access to the internal core environments. Therefore, we believe this work offers a promising approach for producing multicore colloidosomes with adjustable structure and functionalities for the encapsulation of hydrophobic actives.

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Encapsulation of Oil Phases with Different Compositions into a Shell Composed of Nanoparticles of Natural Hydrothermal Silica and Polyelectrolyte Layers

Cited by 6 publications

References 15 publications

Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers

Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers

Preparation and evaluation of organosilica nanocapsules encapsulating DCOIT by using the response surface optimization

Preparation of Multicore Colloidosomes: Nanoparticle-Assembled Capsules with Adjustable Size, Internal Structure, and Functionalities for Oil Encapsulation

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