Encapsulation of porphyrins and chlorins in biodegradable nanoparticles: The effect of dye lipophilicity on the extravasation and the photothrombic activity. A comparative study

Pegaz, B.; Debefve, Elodie; Borle, François; Ballini, Jean‐Pierre; Bergh, Hubert van den; Kouakou-Konan, Yvette Niamien

doi:10.1016/j.jphotobiol.2005.02.003

Cited by 51 publications

(32 citation statements)

References 22 publications

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“…Another example of liposomal drug using in PDT is verteporfin (Visudyne ® ), a semi-synthetic porphyrin derived from protoporphyrin [50]. It was the first photodynamic drug approved for treatment of age-related macular degeneration (AMD) [51].…”

Section: Nanomedicinementioning

confidence: 99%

“…Similar systems were also used to evaluate the efficiency of nanoparticles for the treatment of choroidal neovascularization associated with AMD [51]. Standard porphyrins, pheophorbide a and chlorin e 6 were encapsulated in poly(D,L-lactic acid) nanoparticles.…”

Section: Biodegradable Nanoparticlesmentioning

confidence: 99%

“…It is a liposomal formylation of verteporfin, a semi synthetic porphyrin derived from protoporphyrin. It was approved by the FDA in 2000 for the treatment of AMD [127] and in 2001, for the treatment of pathological myopia [50,51].…”

Section: Liposomes As Photosensitizer Carriersmentioning

confidence: 99%

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Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

326

215

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SummaryPhotodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which delivery of a photosensitizing drug is followed by irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers. PDT -photodynamic therapy; PGA -poly(glycolic acid); PGLA -poly(D,L-lactide-coglycolide); PLA -poly(lactic acid); PS -photosensitizer; PEG -polyethylene glycol; ALA  aminolevulinic acid; m-THPC  5,10,15,20-tetra-(m-hydroxyphenyl)chlorine; m-THPP  meso-tetra(p-hydroxyphenyl); PpIX  protoporphyrin; Hp  hematoporphyrin; Pc4  silicon phthalocyanine; Ig  immunoglobulin; Tf  transferrin; TfR  transferrin receptor; VEGF  vascular endothelial growth factor; EPR  enhanced permeability and retention effect; FRET  fluorescence resonance energy transfer; MRI  magnetic resonance imaging; RES  reticuloendothelial system; ROS  reactive oxygen species; NP  nanoparticle; ND -nanodiamonds; SNP  silica nanoparticle; AMD  age-related macular degeneration; CNV  choroidal neovascularization; PTT  photothermal therapy;

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Section: Nanomedicinementioning

confidence: 99%

Section: Biodegradable Nanoparticlesmentioning

confidence: 99%

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Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

326

215

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“…Depending on preparation method, polymer-based nanoparticles may have either a form of nanospheres (with photosensitizing agent uniformly dispersed on their surface) or nanocapsules (with the drug entrapped inside the polymer membrane) [37][38][39][40]. Although ceramic-based nanoparticles show greater stability, polymeric carrier systems have other advantages.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Nanotechnology for biomedical applications - enhancement of photodynamic activity by nanomaterials

Ulatowska-Jarża¹,

Pucińska²,

Wysocka-Król³

et al. 2011

Bulletin of the Polish Academy of Sciences: Technical Sciences

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Abstract. Over the last two decades nanotechnology has become one of the most dynamically evolving field of research. The unique properties of nanomaterials, not disclosing at microscale, are examined and exploited to extend our understanding of the interactions taking place at atomic or molecular level. Those findings affect research in many areas, like e.g. alternative energy sources, electronics, physics and medicine. In this paper, the possibility of using nanomaterials for the enhancement of photodynamic activity, is discussed. A brief review on drug-delivery facilitating nanomaterials, regarding their characteristic features, is presented. An exemplary application of silver-doped nanomaterials for enhancement of photodynamic properties of two photosensitizers: Photolon and Protoporphyrin IX, is described. Influence of silver-doped nanomaterials addition on the fluorescence intensity of photosensitizers immobilized in silica-titania (SiO2-TiO2) sol was examined via VIS spectroscopy. Influence of sonication on the fluorescence enhancement was also investigated. It was demonstrated that the fluorescence enhancement of photosensitizers depends on the concentration of both: photosensitizer and silver-doped nanoparticles.

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“…42, 43 Faustino et al 44,45 evaluated the meso-tetraphenylporphyrin dimer derivative as a potential photosensitizer in PDT. Recently, Pegaz et al 46 showed that TPP-loaded nanoparticles exhibited more photothrombic efficiency than free TPP. The presence of the gallium atom in the core of TPP increased the quantum yield of singlet oxygen generation by 31%.…”

Section: Trp and Bsa Photooxidations And Binding Of Sensitizers To Bsamentioning

confidence: 99%

Photodynamic activity of chloro(5,10,15,20-tetraphenylporphyrinato)indium(III)

Silva¹,

Pelegrino²,

Tedesco³

et al. 2008

J. Braz. Chem. Soc.

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A atividade fotodinâmica do cloro (5,10,15,20-tetrafenilporfirinato) de índio(III) (InTPP) in vitro foi investigado para possível uso em terapia fotodinâmica (PDT). O rendimento quântico de oxigênio singlete do InTPP (Φ ∆ = 0,72) em DMSO foi maior que da 5,10,15,20-tetrafenilporfirina (TPP) (Φ ∆ = 0,52). Os sítios de ligação entre os fotossensibilizadores e albumina bovina (BSA) são independentes e com células vermelhas de sangue humano (RBC) são cooperativos, com um e quatro sítios de ligação por molécula, respectivamente. As constantes de associação com BSA são (1,15 ± 0,07) × 10 5 e (2,6 ± 0,1) × 10 4 L mol -1 e com RBC são (2,40 ± 0,05) × 10 7 L mol -1 e (7,2 ± 0,2) × 10 4 L mol ) of photosensitizers were used. InTPP was 1.37-1.5 times more effective in the photooxidation of RBC than Photofrin®. Our results indicate that InTPP should be used in future studies of PDT.

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Encapsulation of porphyrins and chlorins in biodegradable nanoparticles: The effect of dye lipophilicity on the extravasation and the photothrombic activity. A comparative study

Cited by 51 publications

References 22 publications

Nanodrug applications in photodynamic therapy

Nanodrug applications in photodynamic therapy

Nanotechnology for biomedical applications - enhancement of photodynamic activity by nanomaterials

Photodynamic activity of chloro(5,10,15,20-tetraphenylporphyrinato)indium(III)

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