Encapsulation of T4 bacteriophage in electrospun poly(ethylene oxide)/cellulose diacetate fibers

Korehei, Reza; Kadla, John F.

doi:10.1016/j.carbpol.2013.03.079

Cited by 108 publications

(57 citation statements)

References 22 publications

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“…This allows the deposition of functional drugs into a drug compatible core phase even when harsh solvents are employed for the outer shell phase. In one example, Korehei and Kadla used co-axial electrospinning to deposit a T4 bacteriophage into hollow poly(ethylene oxide)/cellulose diacetate fi bers and demonstrated that these fi bers could subsequently release bacteriophages capable of killing E. coli in vitro [ 118 ]. The different delivery modes in electrospinning can be seen in Fig.…”

Section: Drug Encapsulation By Co-axial Electrospinningmentioning

confidence: 98%

The Application of Nanotechnology for Implant Drug Release

Andersen

2016

Advances in Delivery Science and Technology

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The use of medical implants is a cornerstone of modern medicine. All implants face, however, a number of challenges including infection and infl ammation which cause many of them to fail. In addition, tissue engineering implants must also direct stem cell differentiation and tissue regeneration in order to work properly. These problems may be overcome using drugs that are delivered directly from the implant. For this to work the drugs have to be protected until they have performed their function, their release must be timed with when they are needed, they may have to affect specifi c regions of an implant only and some drugs must be delivered to specifi c sub-cellular locations in certain cells types. This chapter explores how various forms of nanotechnology may be employed to reach these goals and reviews many of the studies that have used nanotechnology for different implant mediated drug release applications.

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Section: Drug Encapsulation By Co-axial Electrospinningmentioning

confidence: 98%

The Application of Nanotechnology for Implant Drug Release

Andersen

2016

Advances in Delivery Science and Technology

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“…Here, some research has been conducted in order to encapsulate bacteriophages into electrospun biopolymer fibers for controlled liberation at the desired site of action [24,29,45]). …”

Section: Artificially Vectorized Bacteriophagesmentioning

confidence: 99%

A Question of Attire: Dressing Up Bacteriophage Therapy for the Battle Against Antibiotic-Resistant Intracellular Bacteria

Nieth

Verseux

Römer

2014

Springer Science Reviews

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More and more bacteria are developing severe antibiotic resistance. Among them are important intracellular pathogens such as Mycobacterium tuberculosis. Alternatives to classical antibiotics are urgently needed and bacteriophage therapy is a promising candidate for alternative or supplemental treatment. Until now, bacteriophages have been thought to be non-suitable for therapy against intracellular pathogens. Still, a few studies have been carried out to assess the efficacy of bacteriophage therapy against intracellular pathogens both in vitro and in vivo, with variable results. Recently, some successful studies have been conducted, in which bacteriophages were carried into infected cells by different bacterial vectors and killed intracellular pathogens. In this review, we aim to recapitulate the existing literature on bacteriophage therapy of intracellular pathogens and discuss possible ways of bacteriophage entry into infected cells, including different Trojan horse strategies and the question of whether free bacteriophages are able to enter mammalian cells. Finally, we sum up attempts of bacteriophage microencapsulation and speculate about the advantages of artificial vectorization for efficient and targeted intracellular delivery.

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“…Blending PEO with hydrophobic cellulose diacetate was also proved to avoid the rapid release of the phage via manipulating the ratio of hydrophilic/hydrophobic polymers in the shell. 118 Physical blockage has also been proposed as adhesive biodegradable patch for the protection of pruning locations of plants from fungi attacks. Based on soy protein/polyvinyl alcohol and PCL electrospun nanofibers deposited onto a biodegradable rayon membrane, the mat physically blocks fungi penetration, while leaving sufficient porosity for plant breathing.…”

Section: Food Packagingmentioning

confidence: 99%

“…117 An innovative application proposed the use of bacteriophages encapsulated in electrospun fibers. 113,118 Bacteriophages are viruses that can kill prokaryotes and that have already been used for species-specific control of bacteria during different phases of food production and storage. The possibility of using phages to reduce the concentration of bacterial pathogens gained general attention since the introduction of a Listeria monocytogenes-specific phage preparation approved by the Food and Drug Administration in 2006.…”

Section: Food Packagingmentioning

confidence: 99%

Bioactive Applications for Electrospun Fibers

2016

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Electrospinning is a versatile technique providing highly tunable nanofibrous nonwovens. Many biomedical applications have been developed for nanofibers, among which the production of antimicrobial mats stands out. The production of scaffolds for tissue engineering, fibers for controlled drug release, or active wound dressings are active fields of research exploiting the possibilities offered by electrospun materials. The fabrication of materials for active food packaging or membranes for environmental applications is also reviewed. We attempted to give an overview of the most recent literature related with applications in which nanofibers get in contact with living cells and develop a nano-bio interface.

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Encapsulation of T4 bacteriophage in electrospun poly(ethylene oxide)/cellulose diacetate fibers

Cited by 108 publications

References 22 publications

The Application of Nanotechnology for Implant Drug Release

The Application of Nanotechnology for Implant Drug Release

A Question of Attire: Dressing Up Bacteriophage Therapy for the Battle Against Antibiotic-Resistant Intracellular Bacteria

Bioactive Applications for Electrospun Fibers

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