Encapsulation of Thermo-responsive Gel in pH-sensitive Polymersomes as Dual-Responsive Smart carriers for Controlled Release of Doxorubicin

Oroojalian, Fatemeh; Babaei, Maryam; Taghdisi, Seyed Mohammad; Abnous, Khalil; Ramezani, Mohammad; Alibolandi, Mona

doi:10.1016/j.jconrel.2018.08.039

Cited by 105 publications

(42 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Absorbance was immediately determined at 570 nm (reference wavelength 630 nm) using a microplate reader (infinite NanoQuant M 200), Tecan (Zurich, Switzerland). Treated cells in CdS QDs containing medium were compared to control cells in blank plant extract medium (Cell viability=A treated /A control ×100) and expressed as the mean±SD of triplicates [43,44].…”

Section: Mtt Assaymentioning

confidence: 99%

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

Gholami

Dadmehr

Jelodar

et al. 2020

Mater. Res. Express

Self Cite

View full text Add to dashboard Cite

Development of green based synthesis of nanoparticles has been regarded as a novel and safe alternative method compared to conventional methods. Semiconductor cadmium sulfide quantum dots (CdS QDs) possess unique biological and medical applications includes labeling cells, diagnosing of diseases and imaging intercellular events. The present paper reports the biosynthesis of CdS QDs through aqueous extracts of the regenerated hairy roots of Rhaphanus sativus L. as the organic source for both reducing and stabilizing of Cd and S precursor ions. The characterization of synthesized QDs showed maximum absorbance peak of 460 nm and fluorescence spectrum of cadmium sulfide at 530 nm. The results of Transmission Electron Microscope (TEM) and EDS analysis demonstrated that the particles were morphologically spherical with size distribution between 2-7 nm and confirmed presence of CdS QDs. Fourier transform infrared spectroscopy (FT-IR) also showed the active presence of aromatic, amino, and carboxyl groups on the surface of quantum dots. Cytotoxicity effect of the synthesized CdS QDs on two cell lines include MCF-7 breast cancer and AGS gastric cancer were assayed through MTT assay. The results showed significant inhibitory effects of synthesized QDs on treated cells in a dose dependent manner. It was also concluded that CdS QDs had more apoptosis effect on MCF-7 cells rather than AGS cell lines. The obtained results clearly illustrated that the synthesis of CdS quantum dots with standard features would be possible through costeffective, reliable, environmentally friendly and less toxic alternative method compared to chemical and physical processes and the MTT toxicity assay also illustrated the significant apoptotic effects of synthesized CdS QDs on carcinogenesis.

show abstract

Section: Mtt Assaymentioning

confidence: 99%

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

Gholami

Dadmehr

Jelodar

et al. 2020

Mater. Res. Express

Self Cite

View full text Add to dashboard Cite

show abstract

“…It can undergo a phase transition to hydrophobic aggregation above its LCST due to the presence of hydrophilic amide groups and hydrophobic isopropyl groups. 7,8 PNIPAm-based hydrogels owns a LCST of about 32 C, 9,10 which is lower than the human body temperature (37 C). So, PNIPAm and its hydrogels have been studied for the "on-off" drug release utilizing this thermalresponsive property.…”

Section: Introductionmentioning

confidence: 98%

“…So, PNIPAm and its hydrogels have been studied for the "on-off" drug release utilizing this thermalresponsive property. 10,11 However, there are also some disadvantages. The inner of these conventional thermal-responsive materials such as PNIPAm and its hydrogels is hard to respond to the outside temperature changes due to their poor thermal conductivity.…”

Section: Introductionmentioning

confidence: 99%

NIR laser-responsive liquid metal-loaded polymeric hydrogels for controlled release of doxorubicin

et al. 2019

View full text Add to dashboard Cite

show abstract

“…[4,[6][7][8] The existingp lethora of drug transport vehicles is composed of several types of nano-andm icro-structured self-assemblies of amphiphiles. [6,9,10] Liposomes, [11] niosomes, [12] micelles, [13] nano/microparticles, [14] polymersomes [15] and nanogels [16] are notable drug delivery systemsthat have been part of extensive drug delivery research in the hope of achieving desirable outcomes with chemotherapeutic treatments. Significant efforts have been made in order to make these drug carriers bio-responsive for effective release of the drug.…”

Section: Introductionmentioning

confidence: 99%

Efficacious Doxorubicin Delivery Using Glutathione‐Responsive Hollow Non‐phospholipid Vesicles Bearing Lipoyl Cholesterols

et al. 2019

View full text Add to dashboard Cite

In this study, we developed redox‐sensitive vesicles using synthesised lipoyl cholesterol derivatives, a non‐ionic surfactant and an optimum level of free cholesterol. Interestingly, concentration‐dependent self‐assembly was observed by scanning electron microscopy, wherein vesicles manifested as hollow spherical (at 0.15 mm) and triangular (0.50 mm). The redoxresponsive characteristics of the vesicles was probed in the presence of dithiothreitol; they underwent a clear increase in size as observed by dynamic light scattering measurements. These vesicles could easily encapsulate an anticancer drug, doxorubicin, and were observed to be stable in the presence of serum. They showed substantial release of the drug in response to biologically relevant stimulus, that is, glutathione. A toxicity assessment on HeLa and HepG2 cancer cells demonstrated activities of the drug‐loaded vesicles comparable to that of free drug, whereas significantly enhanced toxicity and apoptotic induction were observed against drug‐resistant HeLa cells, which was determined by studying the cellular internalisation of doxorubicin.

show abstract

Encapsulation of Thermo-responsive Gel in pH-sensitive Polymersomes as Dual-Responsive Smart carriers for Controlled Release of Doxorubicin

Cited by 105 publications

References 42 publications

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

NIR laser-responsive liquid metal-loaded polymeric hydrogels for controlled release of doxorubicin

Efficacious Doxorubicin Delivery Using Glutathione‐Responsive Hollow Non‐phospholipid Vesicles Bearing Lipoyl Cholesterols

Contact Info

Product

Resources

About