Encapsulation of thymus vulgaris essential oil in caseinate/gelatin nanocomposite hydrogel: In vitro antibacterial activity and in vivo wound healing potential

Alsakhawy, Sara A.; Baghdadi, Hoda H.; El‐Shenawy, Moustafa A.; Sabra, Sally; El‐Hosseiny, Lobna S.

doi:10.1016/j.ijpharm.2022.122280

Cited by 33 publications

(19 citation statements)

References 128 publications

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“…60 Similarly, nanocomposites loaded with Thymus vulgaris oil contracted more than 95% wounds, whereas only 80% wound contraction was obtained using blank nanocomposites in 16 days. 61 The findings obtained showed that NFHD nanofibers contracted approximately 95%, which is in line with the previously reported studies. However, in our study, NF0 showed comparatively delayed wound healing, which requires further investigation in future.…”

Section: In Vivo Excision Wound Healing Studysupporting

confidence: 92%

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

Mishra

Gupta

Srivastava³

et al. 2023

ACS Appl. Bio Mater.

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Wound dressings with outstanding biocompatibility, antimicrobial, and tissue regeneration activities are essential to manage emerging recalcitrant antifungal infections to speed up healing. In this study, we have engineered p-cymene-loaded gellan/PVA nanofibers using electrospinning. Morphological and physicochemical properties of the nanofibers were characterized using a multitude of techniques to validate the successful integration of p-cymene (p-cym). The fabricated nanomaterials exhibited strong antibiofilm activity against Candida albicans and Candida glabrata compared to pure p-cymene. In vitro biocompatibility assay demonstrated that nanofibers did not possess any cytotoxicity to the NIH3T3 cell lines. In vivo, full-thickness excision wound healing study showed that the nanofibers were able to heal skin lesions faster than the conventional clotrimazole gel in 24 days without forming any scar. These findings unraveled p-cymene-loaded gellan gum (GA)/poly(vinyl alcohol) (PVA) nanofibers as an effective biomaterial for cutaneous tissue regeneration.

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Section: In Vivo Excision Wound Healing Studysupporting

confidence: 92%

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

Mishra

Gupta

Srivastava³

et al. 2023

ACS Appl. Bio Mater.

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“…Micelles are self-assembling nano-scaled spherical structures usually composed of phospholipids and/or polymers in aqueous dispersion. This system can load drugs by entrapping them in the core of copolymer micelles, enhancing the intrinsic water solubility [ 93 ]. While the core of micelles carries hydrophobic drugs, the external hydrophilic groups of the polymer stabilize the structure in an aqueous medium [ 66 ].…”

Section: Soft Nanoparticles and Hydrogels For Wound Healingmentioning

confidence: 99%

“…The micelles’ structure and drug release profile remain the same, releasing the drug at a slow rate, and aiding wound healing. Polymeric micelles-based hydrogels also enhanced the wound-healing effect of Thymus vulgaris essential oil and insulin, in excisional [ 93 ] and diabetic wound models [ 81 ], respectively. Due to the presence of polymers with different surface charges, micelles can modulate the drug release rate by forming chemical bonds between polymer chains and the drug, changing the polymeric conformational structure, or even both mechanisms.…”

Section: Soft Nanoparticles and Hydrogels For Wound Healingmentioning

confidence: 99%

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

et al. 2023

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Wounds are alterations in skin integrity resulting from any type of trauma. The healing process is complex, involving inflammation and reactive oxygen species formation. Therapeutic approaches for the wound healing process are diverse, associating dressings and topical pharmacological agents with antiseptics, anti-inflammatory, and antibacterial actions. Effective treatment must maintain occlusion and moisture in the wound site, suitable capacity for the absorption of exudates, gas exchange, and the release of bioactives, thus stimulating healing. However, conventional treatments have some limitations regarding the technological properties of formulations, such as sensory characteristics, ease of application, residence time, and low active penetration in the skin. Particularly, the available treatments may have low efficacy, unsatisfactory hemostatic performance, prolonged duration, and adverse effects. In this sense, there is significant growth in research focusing on improving the treatment of wounds. Thus, soft nanoparticles-based hydrogels emerge as promising alternatives to accelerate the healing process due to their improved rheological characteristics, increased occlusion and bioadhesiveness, greater skin permeation, controlled drug release, and a more pleasant sensory aspect in comparison to conventional forms. Soft nanoparticles are based on organic material from a natural or synthetic source and include liposomes, micelles, nanoemulsions, and polymeric nanoparticles. This scoping review describes and discusses the main advantages of soft nanoparticle-based hydrogels in the wound healing process. Herein, a state-of-the-art is presented by addressing general aspects of the healing process, current status and limitations of non-encapsulated drug-based hydrogels, and hydrogels formed by different polymers containing soft nanostructures for wound healing. Collectively, the presence of soft nanoparticles improved the performance of natural and synthetic bioactive compounds in hydrogels employed for wound healing, demonstrating the scientific advances obtained so far.

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“…Interestingly, this study proved that this delivering system not only promotes wound closure, but also reduces the inflammatory factor IL-6, while encompassing an increase of VEGF and transforming growth factor-β1. Furthermore, an appreciable antibacterial activity was equally found with this hydrogel disrupting bacterial membranes followed by alkaline phosphatase leakage [ 31 ]. Another relevant study has led to the creation of an electrospun zein/thyme essential oil (TEO) nanofibrous membrane aiming to overcome some drawbacks of the conventional electrospun fibrous wound dressings, such as the lack of adjustment when topically applied on irregular wounds [ 33 ].…”

Section: Pharmacological Wound Healing Evidence Of Iberian Lamiaceaementioning

confidence: 99%

“…Usually, Lamiaceae species are rich essential oil-bearing plants with a great diversity of phenolic compounds, polyphenols, iridoids, diterpenoids, triterpenoids, saponins and, in some restricted cases, pyridine and pyrrolidine alkaloids [ 21 ]. The presence of such compounds has been linked to a wide range of well-documented bioactivities, namely the antioxidant [ 7 , 22 , 23 , 24 , 25 ], anti-inflammatory [ 4 , 26 , 27 , 28 , 29 ] and especially antibacterial activity [ 22 , 23 , 25 , 30 , 31 , 32 , 33 ]. Altogether, this positively influences the wound healing potential of the Lamiaceae species.…”

Section: Introductionmentioning

confidence: 99%

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

et al. 2023

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Skin tissue has a crucial role in protecting the human body from external harmful agents, preventing wounds that frequently demand proper healing approaches. The ethnobotanical knowledge of specific regions with further investigation on their medicinal plants has been paramount to create new and effective therapeutical agents, including for dermatological purposes. This review attempts, for the first time, to investigate the traditional applications of Lamiaceae medicinal plants that are already used by local communities in the Iberian Peninsula in wound healing. Henceforward, Iberian ethnobotanical surveys were reviewed, and the information about the traditional wound healing practices of Lamiaceae was comprehensively summarized. Afterwards, the scientific validation of each Lamiaceae species was exhaustively checked. From this, eight out of twenty-nine Lamiaceae medicinal plants were highlighted by their wound-related pharmacological evidence and are in-depth presented in this review. We suggest that future studies should focus on the isolation and identification of the active molecules of these Lamiaceae, followed by robust clinical trials that may confirm the security and effectiveness of such natural-based approaches. This will in turn pave the way for more reliable wound healing treatments.

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Encapsulation of thymus vulgaris essential oil in caseinate/gelatin nanocomposite hydrogel: In vitro antibacterial activity and in vivo wound healing potential

Cited by 33 publications

References 128 publications

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

Exploration of Antibiofilm and In Vivo Wound Healing Activity of p-Cymene-Loaded Gellan/PVA Nanofibers

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

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