Encapsulation of Valproate-Loaded Hydrogel Nanoparticles in Intact Human Erythrocytes: A Novel Nano-cell Composite for Drug Delivery

Hamidi, Mehrdad; Rafiei, Pedram; Azadi, Amir; Mohammadi-Samani, Soliman

doi:10.1002/jps.22395

Cited by 46 publications

(27 citation statements)

References 25 publications

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“…The obtained data indicate that 148.8 lg of PTX was loaded, with an entrapment efficiency of 46.36%. This amount is notable in comparison to those values reported in the literature for a variety of drugs (Shavi et al, 2010;Hamidi et al, 2011). The observed cell recovery of approximately 75.94% is comparable to the recovery results for various drugs reported in other studies (Magnani et al, 2002;Rossi et al, 2005).…”

Section: Discussionsupporting

confidence: 90%

Engineering erythrocytes as a novel carrier for the targeted delivery of the anticancer drug paclitaxel

Harisa

Ibrahim

Alanazi

et al. 2014

Saudi Pharmaceutical Journal

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Paclitaxel (PTX) is formulated in a mixture of Cremophor EL and dehydrated alcohol. The intravenous administration of this formula is associated with a risk of infection and hypersensitivity reactions. The presence of Cremophor EL as a pharmaceutical vehicle contributes to these effects. Therefore, in this study, we used human erythrocytes, instead of Cremophor, as a pharmaceutical vehicle. PTX was loaded into erythrocytes using the preswelling method. Analysis of the obtained data indicates that 148.8 lg of PTX was loaded/mL erythrocytes, with an entrapment efficiency of 46.36% and a cell recovery of 75.94%. Furthermore, we observed a significant increase in the mean cell volume values of the erythrocytes, whereas both the mean cell hemoglobin and the mean cell hemoglobin concentration decreased following the loading of PTX. The turbulence fragility index values for unloaded, sham-loaded and PTX-loaded erythrocytes were 3, 2, and 1 h, respectively. Additionally, the erythrocyte glutathione level decreased after PTX loading, whereas lipid peroxidation and protein oxidation increased. The release of PTX from loaded erythrocytes followed first-order kinetics, and about 81% of the loaded drug was released into the plasma after 48 h. The results of the present study revealed that PTX was loaded successfully into human erythrocytes with acceptable loading parameters and with some oxidative modification to the erythrocytes.ª 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.

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Section: Discussionsupporting

confidence: 90%

Engineering erythrocytes as a novel carrier for the targeted delivery of the anticancer drug paclitaxel

Harisa

Ibrahim

Alanazi

et al. 2014

Saudi Pharmaceutical Journal

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“…Currently many materials such as polymers, lipids, proteins, carbons, and inorganic metals are under investigation for drug delivery (Yoon et al, 2013). To improve the delivery systems, several types of nanoparticulate systems including polymeric nanoparticles (Hamidi et al, 2011;Hamidi et al, 2012;Azadi et al, 2015), polymeric micelles, solid nanoparticles, lipid-based nanoparticles, such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid drug conjugate (LDC) , nanoliposomes (Azadi and Ashrafi, 2016), inorganic nanoparticles, dendrimers, magnetic nanoparticles, Ferrofluids, and quantum dots have been introduced and investigated previously . Among the various types of nanocarriers, polymeric nanoparticles which are classified to swellable and non-swellable ones, have been considered as promising devices in controlled drug release systems.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of drug release from swellable polymeric nanoparticles

2017

J App Pharma Sci

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This study aims to provide a comparative mathematical analysis of drug release from swellable polymeric delivery systems to find a general model applicable to multi-mechanistic release. Drug release data from various swellable polymeric nanoparticles extracted from the literatures were applied to the eight conventional models. Coefficient of determination (R 2 ) and absolute percent error (E%) were calculated for each set as well as the overall error (OE), the number of error (NE) and the akaike information criterion (AIC) for all sets. The model has the highest R 2 and the number of the error, as well as both the lowest overall error (OE) and the akaike information criterion, was considered as the best one. Among the models Weibull (W) model produced R 2 and OE values of 0.93 and 8.79, respectively. Also, the AIC value and the number of errors less than 5% for the model was -34.93 and 46.15% of a total number of data sets respectively. Mathematical modeling of drug release from a carrier is often attempted to recognize the main determinants of the drug release rate from the carrier with the final goal of the identification of the ideal set of conditions leading to the desired release profile in vivo.

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“…Encapsulation of drug-loaded hydrogel nanoparticles in RBCs and other nano-scale drug formulations has been studied in vitro [139,140]. Loading in RBCs and laser-triggered release of gold nanoparticles has also been reported [141].…”

Section: Particles/carriers Designed For Targeting To or Carriage mentioning

confidence: 99%

Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems

Villa

Anselmo

Mitragotri

et al. 2016

Advanced Drug Delivery Reviews

313

227

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Red blood cells (RBCs) constitute a unique drug delivery system as a biologic or hybrid carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for example, by changing margination within the intravascular space), and modulating immune responses to appended cargoes. Strategies for RBC drug delivery systems include internal and surface loading, and the latter can be performed both ex vivo and in vivo. A relatively new avenue for RBC drug delivery is their application as a carrier for nanoparticles. Efforts are also being made to incorporate features of RBCs in nanocarriers to mimic their most useful aspects, such as long circulation and stealth features. RBCs have also recently been explored as carriers for the delivery of antigens for modulation of immune response. Therefore, RBC-based drug delivery systems represent supercarriers for a diverse array of biomedical interventions, and this is reflected by several industrial and academic efforts that are poised to enter the clinical realm.

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Encapsulation of Valproate-Loaded Hydrogel Nanoparticles in Intact Human Erythrocytes: A Novel Nano-cell Composite for Drug Delivery

Cited by 46 publications

References 25 publications

Engineering erythrocytes as a novel carrier for the targeted delivery of the anticancer drug paclitaxel

Engineering erythrocytes as a novel carrier for the targeted delivery of the anticancer drug paclitaxel

Mathematical modeling of drug release from swellable polymeric nanoparticles

Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems

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