Encapsulation of valproic acid and sodic phenytoin in ordered mesoporous SiO2 solids for the treatment of temporal lobe epilepsy

López, T.; Basaldella, Elena Isabel; Ojeda, María Luisa; Manjarrez, J.; Alexander‐Katz, Roberto

doi:10.1016/j.optmat.2006.03.017

Cited by 47 publications

(22 citation statements)

References 13 publications

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“…This contrasts with the effect of intermittent systemic L-dopa administration, which causes orofacial dyskinesias. In summary, because the nanostructured silica material has been found to be biocompatible with cerebral tissue, 25 we may conclude that it has the potential to be used as a release system for dopamine in patients with Parkinson's disease.…”

Section: Resultsmentioning

confidence: 97%

“…[22][23][24] Using this material, we previously showed an antiepileptic effect in rats implanted with a valproic acid-loaded nanosilica reservoir in the amygdala. 25 Recently, we described the stabilization of dopamine in a nanosilica sol-gel matrix to be used as a controlled drug-release system. 26 In this work, dopamine was incorporated into a silica network structure using the sol-gel method.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

López¹,

Bata-García²,

Esquivel³

et al. 2010

IJN

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Introduction We have evaluated the use of silica–dopamine reservoirs synthesized by the sol–gel approach with the aim of using them in the treatment of Parkinson’s disease, specifically as a device for the controlled release of dopamine in the striatum. Theoretical calculations illustrate that dopamine is expected to assume a planar structure and exhibit weak interactions with the silica surface. Methods Several samples were prepared by varying the wt% of dopamine added during the hydrolysis of tetraethyl orthosilicate. The silica–dopamine reservoirs were characterized by N 2 adsorption, scanning and transmission electron microscopy, and Fourier transform infrared spectroscopy. The in vitro release profiles were determined using ultraviolet visible absorbance spectroscopy. The textural analyses showed a maximum value for the surface area of 620 m 2 /g nanostructured silica materials. The stability of dopamine in the silica network was confirmed by infrared and 13 C-nuclear magnetic resonance spectroscopy. The reservoirs were evaluated by means of apomorphine-induced rotation behavior in hemiparkisonian rats. Results The in vitro dopamine delivery profiles indicate two regimes of release, a fast and sustained dopamine delivery was observed up to 24 hours, and after this time the rate of delivery became constant. Histologic analysis of formalin-fixed brains performed 24–32 weeks after reservoir implantation revealed that silica–dopamine implants had a reddish-brown color, suggesting the presence of oxidized dopamine, likely caused by the fixation procedure, while implants without dopamine were always translucent. Conclusion The major finding of the study was that intrastriatal silica–dopamine implants reversed the rotational asymmetry induced by apomorphine, a dopamine agonist, in hemiparkinsonian rats. No dyskinesias or other motor abnormalities were observed in animals implanted with silica or silica–dopamine.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

López¹,

Bata-García²,

Esquivel³

et al. 2010

IJN

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“…Application of silica particles with the size of 700 nm to 4 μm by injection method has been reported in the literature previously [65][66][67]. Accordingly, the synthesized SBA- 15 Table 3.…”

Section: <Fig8>mentioning

confidence: 99%

Optimization of tetracycline hydrochloride adsorption on amino modified SBA-15 using response surface methodology

Hashemikia

Hemmatinejad

Ahmadi

et al. 2015

Journal of Colloid and Interface Science

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“…The FTIR spectrum of SBA-15 also showed intense typical bands around 1100 and 1200 cm -1 , which are characteristic of silica, as well as other bands relative to the bending modes of hydroxyl groups at 1630 cm -1 and at 950 cm -1 characteristic of the vibrations of Si-OH of terminal hydroxyl groups (silanols), which have an important role in the stability of the drug in the matrix. It was also observed in the SBA-15 spectrum a band at 800 cm -1 , corresponding to the bending vibrations of the Si-O, and another at approximately 470 cm -1 related to the bridging bending modes of the O-Si-O [48].…”

Section: Characterization Of the Materialsmentioning

confidence: 83%

Inclusion of prednicarbate in the SBA-15 silica

Neto

Araujo

Santos

et al. 2015

J Therm Anal Calorim

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The present work describes the development and characterization of a nanostructured mesoporous SBA-15 silica loaded with prednicarbate, a corticosteroid widely used in the treatment for atopic dermatitis, and the assessment of its in vitro release profile in comparison with a conventional cream formulation. The inclusion of prednicarbate in the SBA-15 pores was confirmed by the respective 24 and 16 % decrease in the surface area (S BET ) and mesopores volume (V), in combination with supporting data obtained by thermal analysis (TG and DSC), FTIR spectroscopy, X-ray diffraction, and elemental analysis. Additionally, it has been shown through X-ray diffraction and DSC that the encapsulated molecules remain in an amorphous state, and the protective function of the loading was demonstrated through thermogravimetry by the decrease in the rate of the thermal decomposition reaction of the drug-loaded material (Dm 600-850°C ). Finally, the HPLC-MS/MS method developed was proven to be precise and accurate for the determination of prednicarbate in the receiving fluid samples collected during the in vitro release test using Franz diffusion cells.

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Encapsulation of valproic acid and sodic phenytoin in ordered mesoporous SiO2 solids for the treatment of temporal lobe epilepsy

Cited by 47 publications

References 13 publications

Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

Optimization of tetracycline hydrochloride adsorption on amino modified SBA-15 using response surface methodology

Inclusion of prednicarbate in the SBA-15 silica

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Encapsulation of valproic acid and sodic phenytoin in ordered mesoporous SiO2 solids for the treatment of temporal lobe epilepsy

Cited by 47 publications

References 13 publications

Treatment of Parkinson's disease: nanostructured sol&ndash;gel silica&ndash;dopamine reservoirs for controlled drug release in the central nervous system

Treatment of Parkinson's disease: nanostructured sol&ndash;gel silica&ndash;dopamine reservoirs for controlled drug release in the central nervous system

Optimization of tetracycline hydrochloride adsorption on amino modified SBA-15 using response surface methodology

Inclusion of prednicarbate in the SBA-15 silica

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Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system

Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system