Encapsulation of Vitamin C into β‐Cyclodextrin for Advanced and Regulatory Release

Saha, Subhadeep; Roy, Debadrita

doi:10.5772/intechopen.70035

Cited by 7 publications

(8 citation statements)

References 49 publications

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“…Their unique structures make CDs capable of encapsulating smaller, as well as larger guest molecules (for example, polymers), resulting in the successful encapsulation of drugs, food ingredients (vitamins and fish oil, for example), light and air sensitive ingredients, as well as antibacterial/microbial agents [ 14 , 15 ]. Currently, a vast number of CDs are used in pharmaceutical formulations to improve the water solubility of hydrophobic drugs or to improve delivery rates to physiologic tissues, and/or in regenerative medicine [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes

et al. 2018

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The fabrication of nanofibers by electrospinning has gained popularity in the past two decades; however, only in this decade, have polymeric nanofibers been functionalized using cyclodextrins (CDs) or their inclusion complexes (ICs). By combining electrospinning of polymers with free CDs, nanofibers can be fabricated that are capable of capturing small molecules, such as wound odors or environmental toxins in water and air. Likewise, combining polymers with cyclodextrin-inclusion complexes (CD-ICs), has shown promise in enhancing or controlling the delivery of small molecule guests, by minor tweaking in the technique utilized in fabricating these nanofibers, for example, by forming core–shell or multilayered structures and conventional electrospinning, for controlled and rapid delivery, respectively. In addition to small molecule delivery, the thermomechanical properties of the polymers can be significantly improved, as our group has shown recently, by adding non-stoichiometric inclusion complexes to the polymeric nanofibers. We recently reported and thoroughly characterized the fabrication of polypseudorotaxane (PpR) nanofibers without a polymeric carrier. These PpR nanofibers show unusual rheological and thermomechanical properties, even when the coverage of those polymer chains is relatively sparse (~3%). A key advantage of these PpR nanofibers is the presence of relatively stable hydroxyl groups on the outer surface of the nanofibers, which can subsequently be taken advantage of for bioconjugation, making them suitable for biomedical applications. Although the number of studies in this area is limited, initial results suggest significant potential for bone tissue engineering, and with additional bioconjugation in other areas of tissue engineering. In addition, the behaviors and uses of aliphatic polyester nanofibers functionalized with CDs and CD-ICs are briefly described and summarized. Based on these observations, we attempt to draw conclusions for each of these combinations, and the relationships that exist between their presence and the functional behaviors of their nanofibers.

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Section: Introductionmentioning

confidence: 99%

Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes

et al. 2018

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“…On the other hand, the highest β ‐CD concentration of 10 mmol L −1 was needed to stabilize glucoraphanin, since unchanged ( P < 0.05) glucoraphanin contents were observed after 3 h. Meanwhile, glucoraphanin levels decreased by 62% and 44% after 3 h using 3 mmol L −1 and 6 mmol L −1 β ‐CD concentrations respectively. Likewise, other health‐promoting molecules, like vitamin C, have been encapsulated with β ‐CD . Similar to glucoraphanin behaviour, 74% lower sulforaphane levels were observed in broccoli juice with 10 mmol L −1 β ‐CD at 3 h compared with samples with 3 mmol L −1 β ‐CD (Table ).…”

Section: Resultsmentioning

confidence: 70%

Effects of α‐, β‐ and maltosyl‐β‐cyclodextrins use on the glucoraphanin–sulforaphane system of broccoli juice

et al. 2018

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Cyclodextrins (CDs) are macromolecules with several industrial applications, being particularly used in the food industry as health-promoting compounds protection agents, as flavour stabilizers, or to eliminate undesired tastes and browning reactions, among others. This study shows the effects of α- (10, 30 and 40 mmol L ), β- (3, 6 and 10 mmol L ) and maltosyl-β-CDs (30, 60 and 90 mmol L ) use on the health-promoting glucoraphanin-sulforaphane system of a broccoli juice up to 24 h at 22 °C. Maltosyl-β-CD (90 mmol L ) highly retained glucoraphanin content after 24 h at 22 °C, showing better effectiveness than β-CD (10 mmol L ). Sulforaphane was efficiently encapsulated with β-CD at just 3 mmol L , and the sulforaphane formed was stable during 3 h at 22 °C. On the other hand, 40 mmol L α-CD retained a high glucoraphanin content in broccoli juice. In contrast, glucoraphanin levels in juice without CDs decreased by 71% after 24 h. Consequently, CDs addition may potentially preserve glucoraphanin in this broccoli juice during industrial processing with the possibility to be later transformed by endogenous myrosinase after ingestion to the health-promoting sulforaphane. © 2018 Society of Chemical Industry.

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“…As it can be seen from the spectra, the absorption of b-CD/Vitamin C inclusion complex solution was similar to Vitamin C in absorption spectrum shape (the peaks were observed at around 295 nm), but the absorbance of b-CD/Vitamin C inclusion complex was higher than that of Vitamin C alone. Therefore, these facts were the indicators of inclusion complex formation [44][45][46][47].…”

Section: Absorption Spectrum Of B-cd/vitamin C Inclusion Complexmentioning

confidence: 99%

Functionalized polyvinyl alcohol nanofiber webs containing β–cyclodextrin/Vitamin C inclusion complex

Okur

Sarıçam

Göcek

et al. 2019

Journal of Industrial Textiles

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In the present study, the electrospinning method was used to develop β–cyclodextrin functionalized polyvinyl alcohol nanofiber webs. The electrospinning parameters were adjusted in order to obtain uniform nanofiber webs by incorporation of varying concentrations of polyvinyl alcohol and β–cyclodextrin in the solutions. Subsequently, β–cyclodextrin/Vitamin C inclusion complexes were added into the polyvinyl alcohol solution, and adjusted parameters were used in the electrospinning process of functionalized polyvinyl alcohol nanofiber webs containing β–cyclodextrin/Vitamin C inclusion complexes. The formation of nanofiber webs was demonstrated by using Scanning Electron Microscopy. The presence of the inclusion complex in the functionalized electrospun polyvinyl alcohol nanofiber webs was proven by using ultraviolet–visible spectroscopy and Fourier Transform-Infrared Spectroscopy. Consequently, it was achieved to functionalize polyvinyl alcohol electrospun nanofiber webs by incorporating β–cyclodextrin/Vitamin C inclusion complex, which might be considered to have useful applications in cosmetics, personal-care products, and topical drug delivery.

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Encapsulation of Vitamin C into β‐Cyclodextrin for Advanced and Regulatory Release

Cited by 7 publications

References 49 publications

Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes

Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes

Effects of α‐, β‐ and maltosyl‐β‐cyclodextrins use on the glucoraphanin–sulforaphane system of broccoli juice

Functionalized polyvinyl alcohol nanofiber webs containing β–cyclodextrin/Vitamin C inclusion complex

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