Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes

Ullrich, Martin; Hanuš, Jaroslav; Dohnal, Jiří; Štěpánek, František

doi:10.1016/j.jcis.2012.11.016

Cited by 41 publications

(33 citation statements)

References 16 publications

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“…temperature), presence of functional groups and zeta potential. 60 According to cryo-SEM measurements, hydrogels based on 1 : 1 mixture of MC: KC showed tightly entanglements which might primarily affect the nioplexes stability during the release from the gel network (ESI, † Fig. S6).…”

Section: In Vitro Release Behavior and Mathematical Modelsmentioning

confidence: 99%

Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids

et al. 2017

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Two polysaccharide-based hydrogels made of only kcarrageenan (4%; w/v) or of a mixture of methylcellulose:kcarrageenan (2%; w/v) were used to encapsulate cationic nioplexes. These vesicular particles were made of a synthetic aminolipid and polysorbate-80 (Tween-80), as a non-ionic surfactant agent. According to oscillatory rheological measurements, the presence of nioplexes did not compromise the mechanical integrity of the gels. In vitro niosomal release experiments demonstrated the liberation of nioplexes up to 24 h, and the curves were fitted according to Higuchi, Korsmeyer-Peppas and Weibull equation models, which indicated Fickian-diffusion controlled mechanisms. Besides nioplexes, cervical cancer cells were also entrapped within the biohydrogels. Cell release confirmed that these materials did not affect the cell viability, allowing cells to spread and proliferate after 24 h. The applicability of these biocompatible hydrogels was also extended to gene delivery. In this regard, the best silencing activities were found when cationic niosomes were complexed with antisense oligonucleotides in KC hydrogels. Nioplexes were able to release through the hydrogel and promoted silencing of luciferase expression in the presence of serum without using commercially available cationic lipids. Overall, the formation of such hybrid materials by integrating cationic nioplexes within biodegradable hydrogels provides a new perspective for the delivery of macromolecular therapeutics.

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Section: In Vitro Release Behavior and Mathematical Modelsmentioning

confidence: 99%

Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids

et al. 2017

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“…Faster release from SPC occurred because of its reduced tendency to withhold curcumin. Given the fluidic nature of SPC, curcumin can be eluted more rapidly from SPC systems 66 . DPPC liposomes can withhold a larger number of curcumin molecules, resulting in the slowest release rate.…”

Section: Fluorescence Anisotropy Studiesmentioning

confidence: 99%

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

et al. 2016

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“…There was no substantial difference between the diameter of empty alginate microgels (Table 1) and microgels loaded with liposomes (Table 3). Obviously the encapsulation of liposomes did not interfere adversely with the formation of alginate microgels [46,48]. These microgels crosslinked with 5 mM Ho 3+ and 95 mM Ba 2+ contained 0.6% holmium 3+ (w/w, wet weight) corresponding to a holmium 3+ to alginate monomer ratio of $0.25 (mol/mol).…”

Section: Preparation Of Holmium Crosslinked Alginate Microgels Contaimentioning

confidence: 99%

“…The monodisperse alginate microgels can be prepared easily by JetCutting [44,45]. Importantly, mild crosslinking conditions are used, allowing encapsulation of liposomes in alginate microgels [46][47][48]. Thereby, crosslinking with Ho 3+ (T 2 ⁄ MRI contrast agent) is possible and allows MRI visualization [49].…”

Section: Introductionmentioning

confidence: 99%

Alginate microgels loaded with temperature sensitive liposomes for magnetic resonance imageable drug release and microgel visualization

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Lorenzato

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et al. 2015

European Polymer Journal

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Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes

Cited by 41 publications

References 16 publications

Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids

Cationic nioplexes-in-polysaccharide-based hydrogels as versatile biodegradable hybrid materials to deliver nucleic acids

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

Alginate microgels loaded with temperature sensitive liposomes for magnetic resonance imageable drug release and microgel visualization

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