Encefalitis límbica paraneoplásica: una entidad de difícil diagnóstico

Ramos-Rivas, M; Rojas‐Velasco, Gustavo; Acuña-Hidalgo, R; Márquez-Valero, O. A.; Arellano-Bernal, R H; Castro-Martínez, Enrique

doi:10.33588/rn.4806.2008473

Cited by 3 publications

(1 citation statement)

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“…C orsellis y cols., describieron en 1968 una entidad que denominaron encefalitis límbica por sus características clínico-patológicas 1,2 . Definieron alteraciones afectivas, mnésicas, neurovegetativas y de sueño, que se asociaban a signos inflamatorios del líquido cefalorraquídeo, perturbaciones electroencefalográficas y lesiones de la circunvolución límbica 3,4 . La encefalopatía paraneoplásica por anticuerpos anti-neurales, anti-HU, anti-Yo y anti-Ma, dirigidos contra epítopos citoplasmáticos, sería una de las etiologías 5,6 .…”

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Encefalitis autoinmune reversible y anticuerpos anti-receptores de N-metil-D-aspartato: Report of one case

et al. 2012

Rev. méd. Chile

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Limbic encephalitis is a subacute syndrome characterized by memory impairment, confusion, seizures, hypothalamic dysfunction and psychiatric symptoms. It has been associated to tumors located outside of the central nervous system. In 2007, anti-N-methyl-D-aspartate receptors (NMDAr) antibodies were found in serum and CSF of patients with this particular type of encephalitis. We report a 25-year-old female who, following upper respiratory tract symptoms, developed serious behavioral and consciousness impairment that progressed to coma. Cerebrospinal fluid (CSF) analysis showed a lymphocyte pleocytosis, the electroencephalogram was altered with a slow encephalopathic rhythm and a brain magnetic resonance imaging was normal. Infectious etiologies were ruled out. CSF and serum anti NMDA receptors antibodies were positive.

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