Encephalitis after Vaccination in United States. A Report from the CDC/FDA Vaccine Adverse Event Reporting System. [1990-2010] (P03.151)

Qudah, Zaid Al; Abukwaik, W.; Patel, Hemali; Souayah, Nizar

doi:10.1212/wnl.78.1_meetingabstracts.p03.151

Cited by 9 publications

(12 citation statements)

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“…In a survey over 20 years in the United States, 14 1,396 cases of encephalitis occurred after vaccination. Responsible vaccinations were hepatitis B (354 cases), influenza vaccination (208 cases), vaccination for measles, mumps and rubella‐MMR (208 cases), and vaccination for Haemophilus influenza type B (120 cases).…”

Section: Discussionmentioning

confidence: 99%

Postvaccinal Encephalitis after ChAdOx1 nCov‐19

Zuhorn

Graf

Klingebiel

et al. 2021

Annals of Neurology

122

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The global SARS‐CoV‐2 pandemic has contributed to more than 163 million confirmed infections and 3.3 million deaths worldwide. The severity of the pandemic has led to an unprecedented effort to develop multiple effective vaccines. Due to excellent safety and efficacy data from clinical trials, several vaccines were approved. We report a case series of postvaccinal encephalitis in temporal correlation to vaccination with ChAdOx1 nCov‐19. The diagnostic criteria for possible autoimmune encephalitis were fulfilled. Our patients responded well to immunosuppressive therapy with corticosteroids. The incidence has been estimated to be approximately 8 per 10 million vaccine doses. Complication of postvaccinal encephalitis after ChAdOx1 nCoV‐19 vaccination still appear to be very rare, but need to be diagnosed and treated adequately. Large pooled data from observational epidemiologic studies are necessary to verify causality. ANN NEUROL 2021;90:506–511

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Section: Discussionmentioning

confidence: 99%

Postvaccinal Encephalitis after ChAdOx1 nCov‐19

Zuhorn

Graf

Klingebiel

et al. 2021

Annals of Neurology

122

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“…In the case of AstraZeneca, this proportion rises to 182.5 reports per 100,000 doses. The vast majority of unusual clinical manifestations listed by the INSPQ are considered as without gravity [13]. The occurrence of encephalitis after vaccination with ChAdOx1 nCoV-19 (AZD1222) is reported in several publicly available databases.…”

Section: Open Access Journal Of Neurology and Neurosurgery Discussionmentioning

confidence: 99%

Post COVID-19 Vaccine Encephalitis and Romboencephalitis: Three Cases Report

Khedr

2022

OAJNN

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Background: Since introducing the SARS-CoV-2 vaccination, different adverse effects and complications have been linked to the vaccine. Variable neurological complications have been reported after receiving the COVID-19 vaccine, such as acute encephalopathy. Case presentation:In this report, we describe three cases previously healthy men who developed acute cerebellar and brainstem symptoms with temporal relationship to ChAdOx1 nCov-19, CSF investigations showed lymphocytic pleocytosis. They received five days of 1 gm. methylprednisolone with variable response.Discussion: Extensive workup for different causes of acute encephalopathy, including autoimmune encephalitis, was negative. Also, one patient improved dramatically after receiving methylprednisolone, supporting an immune-mediated mechanism behind his acute presentation. Accordingly, we think the COVID-19 vaccine is the only possible cause of our patient's presentation, giving the temporal relationship and the absence of other risk factors for encephalopathy. Conclusion:the clinician should be aware of the possible neurological complications of the different COVID-19 vaccines. Further research is needed to clarify the pathophysiology of such complications. Large, pooled data from observational epidemiologic studies are necessary to verify causality.

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“…Postvakzinale Enzephalitiden stellen eine bekannte Entität dar. In einem Erhebungszeitraum von 20 Jahren wurden in den Vereinigten Staaten 1396 Fälle postvakzinaler Enzephalitis nach Impfungen gegen Hepatitis B (354 Fälle), Influenza (208 Fälle), Masern, Mumps und Röteln (208 Fälle) und Haemophilus influenzae Typ B (120 Fälle) berichtet [ 8 ]. Bei 708 Patienten (50,7 %) trat die Enzephalitis innerhalb von 14 Tagen nach der Impfung auf.…”

Section: Diskussionunclassified

“…In den gemeldeten Impfregisterdaten wurde durch das Robert-Koch-Institut ein Auftreten innerhalb von maximal 91 Tagen nach Impfung berichtet, während die EMA und die englischen Registerdaten keine Zeitspanne benannten. Entsprechend der US-Erhebung von 1396 Enzephalitisfällen mit 50,7 % aller aufgetretenen Fälle innerhalb von 14 Tagen [ 8 ] definierten wir dieses Intervall als relevanten Zeitraum nach erfolgter Impfung. Dies entsprach für die in den öffentlich zugänglichen Datenregistern gemeldeten Fälle nach Impfung mit ChAdOx1 nCoV-19 einer Inzidenz der möglichen postvakzinalen Enzephalitis von 5 pro 10 Mio.…”

Section: Diskussionunclassified