Encephalitis as a rare manifestation of novel COVID-19 disease, a para-infection or postinfection complication: A systematic review

Khosraviani, Sara; Paybast, Sepideh; Emami, Ali

doi:10.37897/rjn.2020.3.3

Cited by 3 publications

(3 citation statements)

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“…From the first days of the COVID-19 epidemic in China, neurologic manifestations such as myalgia, headaches, and dizziness were reported as symptoms associated with this infection. Despite the reported cases of encephalitis 12 and cognitive impairments, 13 here we provide a detailed report of a case with probable CJD after COVID-19. This is the second case of CJD after SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 82%

“…Totally, 14 cases of this manifestation were reported in this study from which only six of the reported cases had encephalitis according to brain CT and magnetic resonance imaging (MRI). 12 A study in a Chinese setting found cognitive impairments in patients recovered from COVID-19 compared to the controls. In this study, some cognitive tests were correlated with serum CRP level.…”

Section: Introductionmentioning

confidence: 99%

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Is there a link between COVID-19 and Creutzfeldt-Jakob Disease? a Case Report

Nasiri¹,

Naseri²,

Yazdchi³

et al. 2021

J Res Clin Med

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Creutzfeldt-Jakob Disease (CJD) is a rare rapidly progressive neurodegenerative disease. The diagnosis of CJD is based on magnetic resonance imaging (MRI) findings, electro-encephalography (EEG), or 14-3-3 protein detection. We report a case of a previously-healthy 72 years old woman, with evidence of coronavirus disease 2019 (COVID-19), who complained of behavioral changes and rapidly progressive dementia. While hospitalization, she didn't have orientation to time and place and repeated an irrelevant sentence in response to questions. Also, anomia and impaired comprehension was observed. Myoclonic jerks, abnormal signal intensity at bilateral parieto-occipital cortices in MRI, periodic sharp wave complexes in EEG, and increased lactate dehydrogenase in cerebrospinal fluid (CSF), highly recommended CJD for her. This is the second case of CJD after COVID-19 during this pandemic, which can be an alarm to clinicians about the silent impact of COVID-19 on the central nervous system.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Is there a link between COVID-19 and Creutzfeldt-Jakob Disease? a Case Report

Nasiri¹,

Naseri²,

Yazdchi³

et al. 2021

J Res Clin Med

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“…Previous studies have confirmed the neurotropism of the virus by showing an increasing incidence of COVID-induced encephalitis regardless of the severity of COVID-19. 5 However, there are limited reports of PRES in association with COVID-19 infection in the literature. The first report of PRES in association with COVID-19 was described by Kaya and colleagues.…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic Posterior Reversible Encephalopathy Syndrome: A Rare Neurological Complication of COVID-19 Infection

KhanMohammadi

Shahrabi

Koosha

2021

Int Clin Neurosci J

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Neurological complications of COVID-19 are well documented. However, there are limited reports of posterior reversible encephalopathy syndrome (PRES) associated with COVID-19 in the literature. Herein, we described a 21-year-old man with a history of bipolar disease and opioid addiction who was admitted because of COVID-19 infection. He suddenly experienced a convulsive status epilepticus following hypertension crisis. The patient was intubated and underwent antiepileptic and anti-hypertensive therapy. His brain imaging was compatible with PRES. The patient gradually improved and was eventually discharged after 40 days. On the next month follow-up, the patient was able to walk with a cane without a history of seizure. In this report, we aimed to highlight the less common cerebrovascular complication of COVID-19 infection.

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Neurological manifestations of COVID-19 infection: an umbrella review

Vahdati

Ala

Rahmanpour

et al. 2021

Egypt J Neurol Psychiatry Neurosurg

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Background Neurological involvements of COVID-19 are one of the most reported manifestations of this infection. This study aims to systematically review the previous systematic reviews which addressed the neurological manifestations of the COVID-19 infection. Methods Following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, a comprehensive search was conducted in PubMed, Embase, Scopus, Web of Science databases and Google Scholar from December 2019 to December 2020. Articles were critically screened by two independent reviewers and if met the inclusion criteria, entered the study. Assessment of methodological quality was conducted by Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) tool. Statistical analysis was not applicable. From a total of 1302 studies, 308 studies were removed due to their irrelevant title and abstract. After screening the full texts, a total of 66 found to be eligible. Twenty-one studies reported general manifestations of the COVID-19, 13 studies reported cerebrovascular events, 19 olfactory and oral dysfunctions, 5 systematic reviews on Guillen–Barré syndrome (GBS) and 8 articles on the sporadic manifestations like ocular signs and symptoms. The majority of the studies were classified as critically low or low in terms of quality. Conclusion Despite great heterogeneity in the current literature, neurological involvements are an important extra-pulmonary aspect of the COVID-19; most commonly in the form of general manifestations like headache and olfactory disturbances. Long-term effects of this virus on the nervous system must be a research priority for future references.

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Encephalitis as a rare manifestation of novel COVID-19 disease, a para-infection or postinfection complication: A systematic review

Cited by 3 publications

References 0 publications

Is there a link between COVID-19 and Creutzfeldt-Jakob Disease? a Case Report

Is there a link between COVID-19 and Creutzfeldt-Jakob Disease? a Case Report

Hemorrhagic Posterior Reversible Encephalopathy Syndrome: A Rare Neurological Complication of COVID-19 Infection

Neurological manifestations of COVID-19 infection: an umbrella review

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