Encephalographic Studies in Schizophrenia (Dementia Præcox)

Studies of brain dysfunction in schizophrenia.

“…Rubin's results were confirmed by Moore, Nathan, Elliott, and Laubach (55). In the majority of their sixty cases they found evidence of atrophy, enlargement of the ventricular system, and cisternae.…”

Neuropsychological test results associated with psychiatric disorders in adults.

“…There have been numerous reports that schizophrenics, and particularly chronic schizophrenics, show more abnormalities than do normals or other psychiatric patients on physical neurological exams (e.g., Hertzig & Birch, 1966;Pollin, Stabenau, Mosher, & Tupin, 1966;Rockford, Detre, Tucker, & Harrow, 1970), EEGs (e.g., I til, Saletu, & Davis, 1972J. G. Small & Small, 1965;Tucker, Detre, Harrow, & Glaser, 1965), pneumoencephalograms (e.g., Haug, 1963;Moore, Nathan, Elliott, & Laubach, 1933), and histopathologic studies of the brain (e.g., Tatetsu, 1964;Wildi, Linder, & Costoulas, 1967). Also relevant are studies that have suggested a relationship in some cases between the early onset of schizophrenia and early known or possible insults to the brain (Gittelman & Birch, 1967;Lane & Albee, 1966;Mednick, 1970;Pollin et al, 1968).…”

Schizophrenia and brain dysfunction: An integration of recent neurodiagnostic findings.

“…This may be inferred from other studies which demonstrated that the degree of intellectual and personality disintegration ("dementia") correlated positively with the severity of atrophy, especially in the ventricular system (Asano, 1967;Haug, 1962;Huber, 1957;Lemke, 1936). On the other hand, the extremely high rates of abnormality found in some studies (50% to 95%) are unlikely to represent the schizophrenic population as a whole, since these percentages were based on studies of the most severely ill patients, the chronically hospitalized "demented" schizophrenics (Donovan, Galbraith, & Jackson, 1949;Froshaug & Retterstol, 1956;Jacobi & Winkler, 1927;Lemke, 1936;Moore, Nathan, Elliot, & Laubach, 1933). Those studies with a somewhat broader range of schizophrenic illnesses demonstrated that 25% to 70% of the chronic schizophrenic patients manifested cerebral atrophy (Ansink, Buis, & Tolsma, 1963;Asano, 1967;Haug, 1962;Huber, 1957;Young & Crampton, 1974).…”