Encephalopathy at admission predicts adverse outcomes in patients with SARS‐CoV‐2 infection

Tang, Lei; Liu, Shixin; Xiao, Yanhe; Tran, Thi Thanh Van; Choi, Ji Whae; Wu, Jing; Halsey, Kasey; Huang, Raymond Y.; Boxerman, Jerrold L.; Patel, Sohil H.; Kung, David; Liu, Renyu; Feldman, Michael D.; Danoski, Daniel D.; Liao, Wei; Kasner, Scott E.; Liu, Tao; Xiao, Bo; Zhang, Paul J.; Reznik, Michael; Bai, Harrison X.; Yang, Li

doi:10.1111/cns.13687

Cited by 3 publications

(5 citation statements)

References 43 publications

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“…In the research on the occurrence factors of ABE, hemolysis, infection, and G-6-PD de ciency are currently recognized as the main factors that increase the risk of ABE in neonates [18][19][20]. e results of this study also showed that children with these high-risk symptoms had a signicantly higher risk of ABE than those without these symptoms.…”

Section: Discussionsupporting

confidence: 55%

“…The results of this study also showed that children with these high-risk symptoms had a significantly higher risk of ABE than those without these symptoms. For neonates with severe hyperbilirubinemia, infection and hemolysis share common features, that is, both can directly lead to red blood cell destruction and increase blood indirect bilirubin [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Establishment and Evaluation of Influencing Factors and Risk Prediction Model of Severe Neonatal Hyperbilirubinemia Complicated with Acute Bilirubin Encephalopathy

Jiang

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the influencing factors of severe hyperbilirubinemia in neonates complicated with acute bilirubin encephalopathy (ABE) and then build relevant prediction models and evaluate the prediction performance of the models. Methods. The data of 120 neonates with severe hyperbilirubinemia were collected by retrospective analysis. Univariate and multivariate analysis methods were used to analyze the data of 120 children. R software was used to visualize the results of multivariate analysis, and a nomogram model was obtained. The receiver operating characteristic curve (ROC), calibration curve, and decision-making curve (DC) were used to evaluate the discrimination, accuracy, and clinical net profit rate of the model. Results. Multivariate analysis showed that nonfull breastfeeding, high-risk symptoms, and pregnancy complications were independent risk factors for ABE in neonates with severe hyperbilirubinemia. At the same time, the risk of ABE in neonates with severe hyperbilirubinemia increased with the increase of B/A and Hb levels. The ROC curve showed that the area under the curve for the model was 0.908 (95% CI: 0.839–0.960). The calibration curve shows that the actual prediction curve of the model is in good agreement with the corrected prediction curve. Using the cutoff value of the ROC curve as the diagnostic criterion, the threshold probability of the model was calculated to be 38%. The decision curve shows that when 38% is used as the basis for judging whether to take measures to intervene, the profit rate is 61%. Conclusion. The occurrence of ABE in neonates with severe hyperbilirubinemia is affected by many factors, and there is a certain degree of interaction between these factors. Combining multiple factors to construct a risk nomogram model can provide a reference for early clinical detection of high-risk neonates.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Establishment and Evaluation of Influencing Factors and Risk Prediction Model of Severe Neonatal Hyperbilirubinemia Complicated with Acute Bilirubin Encephalopathy

Jiang

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…30 COVID-19 patients with encephalopathy are also more likely to require critical care and intubation and have higher mortality rates. 30,31 Although receipt of treatment modalities such as azithromycin, dexamethasone, and hemoperfusion showed higher odds of mortality on the univariable analysis, these factors were no longer significant in the multivariable analysis. It was possible that patients with worse health status during the course of admission and those with comorbidities were given these treatment modalities; thus, when intubation and comorbidities were included in the analysis, these treatment modalities were no longer statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Mortality among End-Stage Renal Disease Patients with COVID-19 Admitted in a Philippine Tertiary Government Hospital: A Retrospective Cohort Study

2024

Acta Med Philipp

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Background andObjective. Several studies have examined the predictors of mortality among COVID-19-infected patients; however, to date, few published studies focused on end-stage renal disease patients. The present study, therefore, aims to determine the predictors of in-hospital mortality among end-stage renal disease patients with COVID-19 admitted to a Philippine tertiary hospital.Methods. The researcher utilized a retrospective cohort design. A total of 449 adult end-stage renal disease patients on renal replacement therapy diagnosed with moderate-to-severe COVID-19 and were admitted at the National Kidney and Transplant Institute from June 2020 to 2021 were included. Logistic regression analysis was used to determine the factors associated with in-hospital mortality. Results.In-hospital mortality among end-stage renal disease patients with COVID-19 was 31.18% (95% CI: 26.92-35.69%). Older age (OR=1.03), male sex (OR=0.56), diabetes mellitus (OR=1.80), coronary artery disease (OR=1.71), encephalopathy (OR=7.58), and intubation (OR=30.78) were associated with in-hospital mortality. Conclusion.Patients with ESRD and COVID-19 showed a high in-hospital mortality rate. Older age, diabetes mellitus, coronary artery disease, encephalopathy, and intubation increased the odds of mortality. Meanwhile, males had lower odds of mortality than females.

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“…Neurological manifestations may occur in COVID‐19 patients 214,215 . Encephalopathy, which is defined as global cerebral disturbance and expressed as either subsyndromal delirium, delirium, or coma, predicts adverse outcomes in patients with COVID‐19 infection 216 . Delirium is common but often ignored in ICU patients with COVID‐19 217,218 .…”

Section: Prevention For Perioperative Ncdsmentioning

confidence: 99%

“…214,215 Encephalopathy, which is defined as global cerebral disturbance and expressed as either subsyndromal delirium, delirium, or coma, predicts adverse outcomes in patients with COVID-19 infection. 216 Delirium is common but often ignored in ICU patients with COVID-19. 217,218 Identified risk factors include mechanical ventilation, use of restraints, infusion of benzodiazepines, opioids and vasopressors, and administration of antipsychotics; whereas family visitation (in person or online) was associated with less delirium.…”

Section: Delirium Prevention In Patients With Covid-19mentioning

confidence: 99%

Perioperative neurocognitive disorders: A narrative review focusing on diagnosis, prevention, and treatment

Kong

Wang

2022

CNS Neurosci Ther

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Encephalopathy at admission predicts adverse outcomes in patients with SARS‐CoV‐2 infection

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 3 publications

References 43 publications

Establishment and Evaluation of Influencing Factors and Risk Prediction Model of Severe Neonatal Hyperbilirubinemia Complicated with Acute Bilirubin Encephalopathy

Establishment and Evaluation of Influencing Factors and Risk Prediction Model of Severe Neonatal Hyperbilirubinemia Complicated with Acute Bilirubin Encephalopathy

Predictors of Mortality among End-Stage Renal Disease Patients with COVID-19 Admitted in a Philippine Tertiary Government Hospital: A Retrospective Cohort Study

Perioperative neurocognitive disorders: A narrative review focusing on diagnosis, prevention, and treatment

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