Encephalopathy of prematurity

Edwards, A. David

doi:10.1136/archdischild-2019-318563

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…White matter damage (WMD) is a common type of brain injury occurring in premature infants and is among the main causes of cerebral palsy and cognitive impairment 1–3 . The main pathological features of brain WMD in preterm infants are brain atrophy, brain white matter area injury, and periventricular leukomalacia, which is characterized by oligodendrocyte maturation disorder and subsequent myelin sheath dysplasia 4–6 . In addition, WMD also damages axon growth, synaptogenesis, and neurogenesis 7 .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] The main pathological features of brain WMD in preterm infants are brain atrophy, brain white matter area injury, and periventricular leukomalacia, which is characterized by oligodendrocyte maturation disorder and subsequent myelin sheath dysplasia. [4][5][6] In addition, WMD also damages axon growth, synaptogenesis, and neurogenesis. 7 Recent studies have suggested that the pathogenesis of WMD includes oxidative stress, inflammation, free radical damage, cytokine toxicity, and glutamate excitotoxic damage.…”

Section: Introductionmentioning

confidence: 99%

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Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic‐ischemic white matter damage

Liu

Zhang

et al. 2022

CNS Neurosci Ther

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Aim White matter damage (WMD) is the main cause of cerebral palsy and cognitive impairment in premature infants. Although caffeine has been shown to possess neuroprotective effects in neonatal rats with hypoxic‐ischemic WMD, the mechanisms underlying these protective effects are unclear. Herein, proteins modulated by caffeine in neonatal rats with hypoxic‐ischemic WMD were evaluated. Methods We identified differential proteins and performed functional enrichment analyses between the Sham, hypoxic‐ischemic WMD (HI), and HI+caffeine‐treated WMD (Caffeine) groups. Confirmed the changes and effect of proteins in animal models and determined cognitive impairment via water maze experiments. Results In paraventricular tissue, 47 differential proteins were identified between the Sham, HI, and Caffeine groups. Functional enrichment analyses showed that these proteins were related to myelination and axon formation. In particular, the myelin basic protein (MBP), proteolipid protein, myelin‐associated glycoprotein precursor, and sirtiun 2 (SIRT2) levels were reduced in the hypoxic‐ischemic WMD group, and this effect could be prevented by caffeine. Caffeine alleviated the hypoxic‐ischemic WMD‐induced cognitive impairment and improved MBP, synaptophysin, and postsynaptic density protein 95 protein levels after hypoxic‐ischemic WMD by preventing the HI‐induced downregulation of SIRT2; these effects were subsequently attenuated by the SIRT2 inhibitor AK‐7. Conclusion Caffeine may have clinical applications in the management of prophylactic hypoxic‐ischemic WMD; its effects may be mediated by proteins related to myelin development and synapse formation through SIRT2.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic‐ischemic white matter damage

Liu

Zhang

et al. 2022

CNS Neurosci Ther

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“…Current conventional postnatal cranial sonography and conventional brain MRI studies [ 37 ] documented intraventricular hemorrhage and periventricular leukomalacia as gross markers of major destructive lesions. Present neuroimaging tools lack precision to detect more pervasive brain lesions [ 38 ].…”

Section: Neonatal Contributions To Developmental Disordersmentioning

confidence: 99%

A Bio-Social Model during the First 1000 Days Optimizes Healthcare for Children with Developmental Disabilities

Scher

2022

Biomedicines

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Most children with developmental disabilities (DD) live in resource-limited countries (LMIC) or high-income country medical deserts (HICMD). A social contract between healthcare providers and families advocates for accurate diagnoses and effective interventions to treat diseases and toxic stressors. This bio-social model emphasizes reproductive health of women with trimester-specific maternal and pediatric healthcare interactions. Lifelong neuronal connectivity is more likely established across 80% of brain circuitries during the first 1000 days. Maladaptive gene-environment (G x E) interactions begin before conception later presenting as maternal-placental-fetal (MPF) triad, neonatal, or childhood neurologic disorders. Synergy between obstetrical and pediatric healthcare providers can reduce neurologic morbidities. Partnerships between healthcare providers and families should begin during the first 1000 days to address diseases more effectively to moderate maternal and childhood adverse effects. This bio-social model lowers the incidence and lessens the severity of sequalae such as DD. Access to genetic-metabolomic, neurophysiologic and neuroimaging evaluations enhances clinical decision-making for more effective interventions before full expression of neurologic dysfunction. Diagnostic accuracy facilitates developmental interventions for effective preschool planning. A description of a mother-child pair in a HIC emphasizes the time-sensitive importance for early interventions that influenced brain health throughout childhood. Partnership by her parents with healthcare providers and educators provided effective healthcare and lessened adverse effects. Effective educational interventions were later offered through her high school graduation. Healthcare disparities in LMIC and HICMD require that this bio-social model of care begin before the first 1000 days to effectively treat the most vulnerable women and children. Prioritizing family planning followed by prenatal, neonatal and child healthcare improves wellness and brain health. Familiarity with educational neuroscience for teachers applies neurologic diagnoses for effective individual educational plans. Integrating diversity and inclusion into medical and educational services cross socioeconomic, ethnic, racial, and cultural barriers with life-course benefits. Families require knowledge to recognize risks for their children and motivation to sustain relationships with providers and educators for optimal outcomes. The WHO sustainable development goals promote brain health before conception through the first 1000 days. Improved education, employment, and social engagement for all persons will have intergenerational and transgenerational benefits for communities and nations.

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Gene-Environment Interactions During the First Thousand Days Influence Childhood Neurological Diagnosis

Scher¹

2022

Seminars in Pediatric Neurology

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Encephalopathy of prematurity

Cited by 4 publications

References 6 publications

Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic‐ischemic white matter damage

Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic‐ischemic white matter damage

A Bio-Social Model during the First 1000 Days Optimizes Healthcare for Children with Developmental Disabilities

Gene-Environment Interactions During the First Thousand Days Influence Childhood Neurological Diagnosis

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