Encoded and Multiplexed Surface Plasmon Resonance Sensor Platform

Kastl, Katja; Lowe, Christopher R.; Norman, C. E.

doi:10.1021/ac8011818

Cited by 17 publications

(16 citation statements)

References 37 publications

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“…The most well-studied systems involve alkanethiols grown on Au surfaces [8,9,78,79,104,117,122], although sulphur also shows a strong affinity towards the other noble/ coinage metals, including Ag [9], Pt, Cu, Hg and Pd. Au is most often chosen due to its inertness and resilience to oxidation-so we shall start by discussing this system.…”

Section: Self Assembled Monolayersmentioning

confidence: 99%

Magnetic biosensor technologies for medical applications: a review

Llandro

Palfreyman

Ionescu

et al. 2010

Med Biol Eng Comput

204

117

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In this review we discuss conventional methods of performing biological assays and molecular identification and highlight their advantages and limitations. An alternative approach based on magnetic nanotechnology is then presented. Firstly, magnetic carriers are introduced and their biocompatibility and functionalisation discussed, with spotlights on functionalisation via self assembled monolayers and on methods of reducing nonspecific binding. In addition an introduction is provided to the basic physical concepts behind the various types of sensors used to detect magnetic labels. Finally, progress in the field of magnetic biosensors and the outlook for the future are discussed.

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Section: Self Assembled Monolayersmentioning

confidence: 99%

Magnetic biosensor technologies for medical applications: a review

Llandro

Palfreyman

Ionescu

et al. 2010

Med Biol Eng Comput

204

117

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“…The purpose of adding casein after the enzyme adsorption is to prevent false signal caused by the binding of this blocking protein on Au nanopyramids not covered by the antibody. 27 In summary, we have demonstrated that templated nanopyramid arrays with sharp nanotips exhibit strong SPR due to the efficient localization of electromagnetic field. The templating technology is scalable and compatible with standard microfabrication, promising for developing sensitive chemical and biological sensors for real-time and label-free detection.…”

mentioning

confidence: 78%

Nanopyramid surface plasmon resonance sensors

Chung

Lin

Schultz

et al. 2010

Applied Physics Letters

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We report the achievement of sensitive chemical and biological sensing using periodic gold nanopyramids with nanoscale sharp tips created by a simple and scalable colloidal templating approach. The sharp tips and the long-range periodic structure of the nanopyramid arrays enable the excitement of both localized and propagating surface plasmons. The optical reflection and the detection sensitivity of the templated nanopyramid surface plasmon resonance sensors agree reasonably well with the theoretical predictions using a finite-difference time-domain model. We have also demonstrated that specific antigen-antibody binding can be detected by using nanopyramid arrays in a real-time and label-free manner. © 2010 American Institute of Physics. ͓doi:10.1063/1.3460273͔Surface plasmon resonance ͑SPR͒ technique is of great importance for monitoring binding events in biological systems because it offers a direct and label-free platform for rapid screening test.1-7 Surface plasmons ͑SPs͒ are electromagnetic waves that propagate along a metal/dielectric interface and can be pictured as a traveling charge density wave on the surface of a metal. 8,9 The coupling of incident light with free electrons in metal forms SP waves that are essentially confined to the metal/dielectric interface, leading to a strong concentration of electromagnetic field. The adsorption of molecules to a metal surface significantly changes the oscillation of SPs, resulting in the modulation of light output. The modulation could be monitored by the angular distributions of reflection and transmission, wavelength, intensity, phase, and polarization changes. 1,10 Compared to other immunoassays, such as enzyme-linked immunosorbent assay and radioimmunoassay, 11 the SPR technique is highly promising for rapid and sensitive biosensing because the label-free and real-time characteristics of SPR sensors shorten the sample preparation time, minimize the interference of conjugating radioactive or enzyme labels, and enable direct analyte detection without a sandwich format. 1,2,12 To generate SPs, the difference in the momentum of incident light and SP must be compensated. 9 In the traditional Kretschmann configuration of the attenuated total reflection method, a prism is used to couple the incident light to SPs.10 However, the bulky experimental setup impedes miniaturization and integration in microfluidic systems. 13 The exploitation of localized SPR ͑LSPR͒ around metal nanoparticles is favorable for developing planar on-chip-based sensors.14-16 However, the stochastic separation between neighboring nanoparticles that significantly affects LSPR impedes the sensing reproducibility. Periodically patterned nanostructures, which support both localized and propagating SPR, therefore draw great attention due to their high reproducibility. [17][18][19][20][21] We have developed a scalable bottom-up technique for generating wafer-sized periodic gold nanopyramids with nanoscale tips as an efficient surface-enhanced Raman scattering substrate. [22][23][24] Here we demonst...

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“…Copyright 2008 Springer Science + Business Media); (M) Optical image of octagonal graticles with optical gratings etched into the surface and codes cut into the sides for multiplexing. (Reprinted with permission from Ref 52. Copyright 2008 American Chemical Society.…”

Section: Strategies For Particle Encodingmentioning

confidence: 99%

Encoded anisotropic particles for multiplexed bioanalysis

Cederquist

Dean

Keating

2010

WIREs Nanomed Nanobiotechnol

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Encoded anisotropic nano- and microparticles represent an exciting new class of detection and identification strategies for bioanalysis. These particles are synthesized in a number of different ways and can be encoded by shape, composition, topographical features, or optical properties. In this review, we explore synthetic methods for the formation of anisotropic encoded particles and evaluate these systems as multiplexed biosensing platforms. Suspension arrays using anisotropic particles have been used to detect a range of biological species including proteins, nucleic acids, spores, cells, and small molecules. Because in many cases a large number of codes should be obtainable, the potential exists for high levels of multiplexing (thousands or more). The bulk of work in this area to date has focused on initial proof of principle synthesis and identification; however, multiplexed bioassays have been demonstrated for a number of different anisotropic carrier particles and are beginning to be adopted in commercial assays.

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Encoded and Multiplexed Surface Plasmon Resonance Sensor Platform

Cited by 17 publications

References 37 publications

Magnetic biosensor technologies for medical applications: a review

Magnetic biosensor technologies for medical applications: a review

Nanopyramid surface plasmon resonance sensors

Encoded anisotropic particles for multiplexed bioanalysis

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