The Discrete Global Grid System (DGGS) provides a foundational framework for the digital Earth, where uniform intercell distances are essential for accurate numerical simulations. However, due to the spherical topology, achieving strictly equidistant spherical grid cells is impractical. Most existing studies have focused on regional scales, which are constrained by data acquisition limitations and render global equidistant optimization algorithms economically infeasible. The equidistant characteristics of cells are influenced by map projections and often exhibit regional variations. In this paper, we analyze these equidistant characteristics and construct an equidistant pattern for an icosahedral hexagonal DGGS. By integrating this pattern into the icosahedral orientation method, we develop a regional-scale equidistant optimization method for DGGS. Experiments on river network extraction in the Yangtze River Basin demonstrate significant improvements: the equidistance of grid cells covering the region increased by over 34.2%, while the accuracy of river network extraction improved by 51.41%. Moreover, this method is extensible to other grid models, enhancing the broader applicability of DGGS.