Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibres from the colon

Blumberg, H.; Haupt, P.; Jänig, Wilfrid; Köhler, W

doi:10.1007/bf00584710

Cited by 123 publications

(67 citation statements)

References 23 publications

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“…For example, a large population of low threshold mechanoreceptors innervates the rectum 4 ; these are much sparser in the colonic/splanchnic pathway 14 . In contrast, splanchnic afferents innervating the colon are largely medium-to-high threshold mechanonociceptors 18 which are not as abundant in pelvic pathways 19 . In the mouse large intestine, systematic studies have demonstrated significant differences in both mechanosensitivity 1,19 and chemosensitivity 20 between spinal afferents in pelvic and splanchnic pathways.…”

Section: Discussion (1586 Words)mentioning

confidence: 95%

Sensory innervation of the guinea pig colon and rectum compared using retrograde tracing and immunohistochemistry

Chen

Olsson

Sharrad

et al. 2016

Neurogastroenterology Motil

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Section: Discussion (1586 Words)mentioning

confidence: 95%

Sensory innervation of the guinea pig colon and rectum compared using retrograde tracing and immunohistochemistry

Chen

Olsson

Sharrad

et al. 2016

Neurogastroenterology Motil

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“…In this respect, it has been shown that C polymodal nociceptors innervate the mucosa of the anal canal (Clifton, Coggeshall, Vance & Willis, 1976) and that the majority of sacral afferents activated by distension of the colon are Ad or C polymodal fibres (Clifton et al 1976;Blumberg et al 1983; see also Jiinig & Morrison, 1986). By comparison with colo-rectal distension, intraperitoneal bradykinin elicited more activity in neurones with total nociceptive convergence and activated 50 % of the neurones with partial nociceptive convergence tested (Villanueva et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Convergence of visceral and somatic inputs onto subnucleus reticularis dorsalis neurones in the rat medulla.

Roy

Zhu

Villanueva

et al. 1992

The Journal of Physiology

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SUMMARY1. In anaesthetized rats, recordings were made within the medullary subnucleus reticularis dorsalis (SRD) from neurones that exhibited convergence of nociceptive inputs from the entire surface of the body. Neurones with total nociceptive convergence responded to supramaximal percutaneous electrical stimuli (2 ms duration) with early and late peaks due to the activation of Ad and C fibres, respectively, no matter which part of the body was stimulated. Neurones with partial nociceptive convergence responded to identical stimuli with an A& peak of activation regardless of which part of the body was stimulated and with a C peak of activation from some, mainly contralateral, parts of the body. The characteristics of the responses of these neurones to graded colo-rectal distension (< 100 mmHg) were analysed.2. The majority of neurones with total nociceptive convergence (n = 13 out of 16) responded to colo-rectal distension by increasing their firing rates. Although these neurones were virtually unresponsive to the lowest pressure employed (12-5 mmHg), they increased their discharges monotonically for distentions in the 26-100 mmHg range and these responses were sometimes followed by after-discharges. One of these neurones, which exhibited a high level of spontaneous activity, was inhibited during colo-rectal distension. None of the neurones with partial nociceptive convergence recorded (n = 10) ever changed its firing rate during increases of intracolonic pressure up to 100 mmHg.3. It is concluded that neurones with total nociceptive convergence give monotonic stimulus-response relationships for colo-rectal distensions. Thus, neurones with total nociceptive convergence can encode the strength of visceral stimuli, probably within the noxious range, just as they have previously been shown to do for thermal and mechanical cutaneous stimuli. Together with previous electrophysiological and neuroanatomical findings, this study provides further evidence for the convergence of noxious inputs onto single SRD neurones.

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“…46,81 Similar afferent endings have been confirmed in other regions of the gut in several species. [82][83][84] These vascular afferent endings are also associated with other viscera, including the spleen, ovary, bladder and pancreas. 85 Endings of this type are sensitive to ischaemia, hypoxia and capsaicin, [86][87][88] and they are believed to comprise a major type of nociceptor.…”

Section: Type V: Spinal Vascular Afferentsmentioning

confidence: 99%

Extrinsic primary afferent signalling in the gut

Brookes

Spencer

Costa

et al. 2013

Nat Rev Gastroenterol Hepatol

246

216

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Visceral sensory neurons activate reflex pathways that control gut function and also give rise to important sensations, such as fullness, bloating, nausea, discomfort, urgency and pain. Sensory neurons are organised into three distinct anatomical pathways to the central nervous system (vagal, thoracolumbar and lumbosacral). Although remarkable progress has been made in characterizing the roles of many ion channels, receptors, and second messengers in visceral sensory neurons, the basic aim of understanding how many classes there are, and how they differ, has proven difficult to achieve. We suggest that there are just five structurally distinct types of sensory endings in the gut wall that account for essentially all of the primary afferent neurons in the three pathways. Each of these five major structural types of endings seems to show distinctive combinations of physiological responses. These types are: 'intraganglionic laminar' endings in myenteric ganglia; 'mucosal' endings located in the subepithelial layer; 'muscular mucosal' afferents, with mechanosensitive endings close to the muscularis mucosae; 'intramuscular' endings, with endings within the smooth muscle layers; and 'vascular' afferents, with sensitive endings primarily on blood vessels. 'Silent' afferents might be a subset of inexcitable 'vascular' afferents, which can be switched on by inflammatory mediators.Extrinsic sensory neurons comprise an attractive focus for targeted therapeutic intervention in a range of gastrointestinal disorders.2

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Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibres from the colon

Cited by 123 publications

References 23 publications

Sensory innervation of the guinea pig colon and rectum compared using retrograde tracing and immunohistochemistry

Sensory innervation of the guinea pig colon and rectum compared using retrograde tracing and immunohistochemistry

Convergence of visceral and somatic inputs onto subnucleus reticularis dorsalis neurones in the rat medulla.

Extrinsic primary afferent signalling in the gut

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