For scientific progress, access to information and data is of highest importance. While in the past, scientific results in chemistry were published in most of the cases without original data records, a currently arising cultural change concerning the provision of research data offers new chances for the quality and speed of scientific progress. The repository Chemotion is an infrastructure that was established for chemistry and related disciplines to preserve molecular synthesis and characterization data. The focus of the repository is on data of chemical reactions and processes including the corresponding analytical data such as chromatography or spectroscopy data. The repository provides these data for other scientists to foster their re‐use and to allow a fast reproduction of published work. To achieve this goal, several automated but also peer‐review mechanisms in the repository support the providers with suitably preparing their data.