End-Stage Renal Disease Among HIV-Infected Adults in North America

Abraham, Alison G.; Althoff, Keri N.; Jing, Yuezhou; Estrella, Michelle M.; Kitahata, Mari M.; Wester, C. William; Bosch, Ronald J.; Crane, Heidi M.; Eron, Joseph J.; Gill, M. John; Horberg, Michael A.; Justice, Amy C.; Klein, Marina B.; Mayor, Ángel M.; Moore, Richard D.; Palella, Frank J.; Parikh, Chirag R.; Silverberg, Michael J.; Golub, Elizabeth T.; Jacobson, Lisa P.; Napravnik, Sonia; Lucas, Gregory M.; Kirk, Gregory D.; Benson, Constance A.; Collier, Ann C.; Boswell, Stephen L.; Grasso, Chris; Mayer, Ken; Hogg, Robert S.; Harrigan, Richard; Montaner, Julio S. G.; Cescon, Angela; Brooks, John T.; Buchacz, Kate; Gebo, Kelly A.; Rodríguez, Benigno; Thorne, Jennifer E.; Goedert, James J.; Rourke, Sean B.; Burchell, Ann; Rachlis, Anita; Hunter-Mellado, Robert F.; Deeks, Steven G.; Martin, Jeffrey N.; Saag, Michael S.; Mugavero, Michael J.; Willig, James H.; Dubrow, Robert; Fiellin, David A.; Sterling, Timothy R.; Haas, David W.; Bebawy, Sally; Turner, Megan; Gange, Stephen J.; Anastos, Kathryn; McKaig, Rosemary G.; Freeman, Aimee; Lent, Carol; Rompaey, Stephen E. Van; Webster, Eric; Morton, Liz; Simon, Brenda; Lau, Bryan; Zhang, Jinbing; Modur, Shari; Hanna, David B.; Rebeiro, Peter F; Wong, Chung F.; Mendes, Adell

doi:10.1093/cid/ciu919

Cited by 150 publications

(113 citation statements)

References 35 publications

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“…29 Kidney dysfunction is often multifactorial in older HCV-infected patients. Besides the less common immune-mediated renal damage secondary to cryoglobulinemia, lifestyle factors, such as substance abuse 30,31 and co-morbid diseases common with aging, such as diabetes and hypertension 31 are also important determinants of worsening renal function in HCV-infected persons.…”

Section: Hcv Infection and Extra-hepatic Clinical Outcomesmentioning

confidence: 99%

Hepatitis C Virus Infection in the Older Patient

Reid

Price

Tien

2017

Infectious Disease Clinics of North America

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Section: Hcv Infection and Extra-hepatic Clinical Outcomesmentioning

confidence: 99%

Hepatitis C Virus Infection in the Older Patient

Reid

Price

Tien

2017

Infectious Disease Clinics of North America

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“…In the North American AIDS Cohort Collaboration on Research and Design study, endstage renal disease risk was significantly higher for black patients, those with unsuppressed viral loads while on ART, those with lower CD4 þ counts, and those with a history of AIDS. Three well established risk factors for end-stage renal disease in the general population-diabetes mellitus, hypertension, and HCV infection-were also highly linked to the risk of end-stage renal disease [57].…”

Section: Renal Insufficiencymentioning

confidence: 99%

Extrahepatic comorbidities associated with hepatitis C virus in HIV-infected patients

Soriano

Berenguer

2015

Current Opinion in HIV and AIDS

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“…Similarly, another study reported that viral suppression over time was associated with favorable changes in estimated GFR in subjects with advanced HIV disease at baseline [11]. Additionally, a recent study from a North American consortium of HIV cohorts reported that the incidence of end-stage renal disease (ESRD) among HIV-positive subjects that maintained durable viral suppression was similar to age-, sex-, and race-matched ESRD rates in the general population [12]. In contrast, we found no association between current CD4 count and baseline iGFR or iGFR slope, consistent with a prior report [6].…”

Section: Discussionmentioning

confidence: 99%

Factors associated with iohexol-based glomerular filtration rate slope over 36 months in HIV-negative and HIV-positive individuals

Lucas

Atta²,

Zook

et al. 2016

Aids

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Background Monitoring kidney function is important in HIV-positive persons, but creatinine-based estimates of glomerular filtration rate (GFR) have limitations. There are little to no data available assessing GFR trends in HIV-positive persons using a gold-standard measure of GFR. Methods We measured GFR based on iohexol plasma disappearance (iGFR) annually for 3 years in non-diabetic, HIV-negative and HIV-positive volunteers with normal estimated kidney function. We used mixed linear models to evaluate factors associated with baseline iGFR and iGFR slope. Results 100 HIV-negative and 191 HIV-positive, predominantly black individuals (median age 49 years) participated in the study and completed a total of 960 iGFR assessments over a median of 36 months. Despite similar estimated GFR at baseline, average iGFR values were lower in HIV-positive compared with HIV-negative participants (103.2 vs. 110.8, mL/min/1.73m2, P=0.004). However, subsequent iGFR slope was not significantly different in HIV-positive and HIV-negative subjects. In the HIV-positive group, the presence of carotid plaque and hepatitis C virus coinfection were associated with significantly lower iGFR values at baseline. A non-suppressed HIV RNA level at baseline was associated with a significantly more rapid iGFR decline compared with individuals with HIV RNA < 400 copies/mL (−4.69 vs. −1.31 mL/min/1.73 m2 per year, P=0.005). Other factors significantly associated with iGFR slope included albuminuria and glycosylated hemoglobin. Conclusions Compared with HIV-negative persons, HIV-positive participants had significantly lower baseline iGFR, despite similar estimated GFR in the two groups. Non-suppressed HIV RNA at baseline was associated with a more rapid iGFR decline over 3 years.

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End-Stage Renal Disease Among HIV-Infected Adults in North America

Abstract: The risk of ESRD remains high among HIV-infected individuals in care but is declining with improvements in virologic suppression. HIV-infected black persons continue to comprise the majority of cases, as a result of higher viral loads, comorbidities, and genetic susceptibility.

Cited by 150 publications

References 35 publications

Hepatitis C Virus Infection in the Older Patient

Hepatitis C Virus Infection in the Older Patient

Extrahepatic comorbidities associated with hepatitis C virus in HIV-infected patients

Factors associated with iohexol-based glomerular filtration rate slope over 36 months in HIV-negative and HIV-positive individuals

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