End-Stage Renal Disease Following Carboplatin Chemotherapy for a Nasopharyngeal Carcinoma

Tarrass, Faissal; Benmensour, M.; Bayla, A.

doi:10.1080/08860220701643591

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Carboplatin is considered to be much less nephrotoxic than cisplatin, however, chronic kidney disease (CKD) secondary to carboplatin administration has been reported. 66 Alkylating agents including ifosfamide and cyclophosphamide have also been implicated in CKD in cancer survivors. Ifosfamide causes proximal tubular injury resulting in glycosuria, renal tubular acidosis, hypokalemia, hypophosphatemia, and proteinuria that may not be immediately evident.…”

Section: Effects Of Chemotherapymentioning

confidence: 99%

Medical Issues in Cancer Survivors—A Review

Miller

Triano

2008

The Cancer Journal

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Cancer survivorship is an emerging area of scientific and clinical interest. Several decades ago, most people diagnosed with cancer did not live long beyond their initial diagnosis. Today the number of cancer survivors exceeds ten million, and this group may experience unique healthcare issues related to their cancer treatment. Chemotherapy, surgery, and radiation therapy each have their own late and long-term complications. It is imperative for clinicians who are caring for cancer survivors to be aware of long-term complications of therapy and to treat these appropriately. When cancer therapy has successfully added years of life, it is equally as important that medical care assures the best quality of life during those years.

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Section: Effects Of Chemotherapymentioning

confidence: 99%

Medical Issues in Cancer Survivors—A Review

Miller

Triano

2008

The Cancer Journal

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Platinum

Lansdown

2023

Patty's Toxicology

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Platinum is ubiquitous in the human environment and is present in plants and animals, human food chains, airborne particles in inner‐city areas, and factory environments. It is a rare transitional metal with many uses in medicine, dentistry, and industrial applications. These include catalytic converters, electrical engineering, computers, space science, chemical syntheses, and jewelry. Platinum forms numerous durable alloys for clinical and industrial applications, and very many inorganic and organic compounds some of which are profound oxidizing agents and corrosive to skin and eyes. Others like the co‐ordination complexes, which are antimitotic through DNA binding, are potent anticancer drugs. The toxicity profile for platinum compounds is incomplete but permitted exposure levels (PEL) are shown for key materials. Respiratory distress, allergy, and hypersensitivity are principal hazards encountered through inhalation of airborne nanoparticles in mining, recycling, and emissions from vehicle exhaust systems. Metabolic pathways and excretion patterns involving liver and kidneys are discussed in relation to population studies. Urine analyses are clinical measures of platinum exposure. The anticancer/antimitotic drugs including cis ‐platin and carboplatin are clinically efficacious but cause nephrotoxicity, ear and sensi‐neural hearing, and possible carcinogenicity. Children are more sensitive. Experiments in animal models and cultured cells have contributed little in the understanding of hazards associated with platinum and related compounds. Whilst evidence of mutagenicity, DNA binding, clastogenicity is presented in standard laboratory screens, the 15th National Toxicology Program, Report on Carcinogens (2021) states that cis ‐platin should be reasonably anticipated to be a human carcinogen, despite no conclusive human epidemiological studies being available.

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Nephrotoxicity of Chemotherapy Agents

Valika

Shirali

2015

Onconephrology

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End-Stage Renal Disease Following Carboplatin Chemotherapy for a Nasopharyngeal Carcinoma

Cited by 4 publications

References 18 publications

Medical Issues in Cancer Survivors—A Review

Medical Issues in Cancer Survivors—A Review

Platinum

Nephrotoxicity of Chemotherapy Agents

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