End-Tidal Partial Pressure of Carbon Dioxide and Acute Mountain Sickness in the First 24 Hours Upon Ascent to Cusco Peru (3326 meters)

Douglas, Danielle J.; Schoene, Robert B.

doi:10.1016/j.wem.2010.01.003

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Up to now, several studies have been conducted focusing on physiological aspects and mechanisms of headache as the major symptom of AMS. Nowadays, AMS is defined as altitude-induced headache in addition to at least one typical symptom such as anorexia, nausea, vomiting, insomnia, dizziness and fatigue [ 1 , 12 , 15 – 17 ] . Altitude above 5500m leads to severe hypoxemia, hypocapnia and alkalosis in addition to progressive impairment of physiological function of individuals.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of Headache at Altitude among Trekkers; A comparison between Acute Mountain Sickness and Non-Acute Mountain Sickness Headache

et al. 2012

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Purpose: Headache at altitudes has had an incidence of 25-62% through many related studies. Many reasons are identified concerning headache at altitudes such as acute mountain sickness (AMS), sinus headache, migraine, tension type headache, and frontal tension headache. This study tried to compare different types of headache among trekkers on Mount Damavand, a 5671m mountain, Iran, to find their incidence and related symptoms and signs.Methods: Through a cross-sectional study, we evaluated headache incidence and its correlation to AMS among people who climbed Mount Damavand. Lake Louise Score, a self-report questionnaire, was applied to make AMS diagnosis through three separate stages of trekking programs. Chi-square test was employed as the main mean of analysis.Results: Totally, 459 between 13-71 year olds participated in the study among which females were 148 (32.1%) and males 311 (67.8%). Headache was found in 398 (86.7%) among whom 279 (70%) were proved as AMS. Investigating the types of headache in the cases of AMS showed 64.5% to be of steady, 31% throbbing and 4.5% stabbing characters which had significant differences with a P value = 0.003. The majority of headaches were stated as frontal (38.9%) and the least prevalence belonged to the parietal area (4.4%), while global headache was reported in 27%.

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Section: Introductionmentioning

confidence: 99%

“…Headache starts as early as 8-24 hours after arrival at 2000m but often is most felt after 48-72 hours [ 15 ] .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Headache at Altitude among Trekkers; A comparison between Acute Mountain Sickness and Non-Acute Mountain Sickness Headache

et al. 2012

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“…Previous studies have demonstrated variable results with end tidal carbon dioxide and altitude. Douglas et al demonstrated an increase in ETCO 2 with higher altitude in Cusco, Peru for a 2 day climb [ 6 ]. However, over 30% of subjects were lost to follow up in that study.…”

Section: Discussionmentioning

confidence: 99%

Does a change in end-tidal carbon dioxide level predict high altitude mountain sickness?

Thundiyil

Williams

Little

et al. 2023

Heliyon

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“…Partial pressure of oxygen (PaO 2 ) 5 , the partial pressure of carbon dioxide (PaCO 2 ) 6 , the saturation of oxygen (SaO 2 ) 7 , 8 , arterial oxygen content (CaO 2 ) 9 , oxygen tension at 50% haemoglobin saturation (P50) 10 and haemoglobin 11 were thought to be hypoxia-sensitive and evidenced either as independent predictors or factors related to the subsequent development of AMS; however, speculation remains regarding their importance in the prediction of AMS. To date, studies concerning the predictive value of blood gas testing are rather limited.…”

Section: Introductionmentioning

confidence: 99%

Establishing a prediction model of severe acute mountain sickness using machine learning of support vector machine recursive feature elimination

Yang¹,

Wu²,

Yang³

et al. 2023

Sci Rep

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Severe acute mountain sickness (sAMS) can be life-threatening, but little is known about its genetic basis. The study was aimed to explore the genetic susceptibility of sAMS for the purpose of prediction, using microarray data from 112 peripheral blood mononuclear cell (PBMC) samples of 21 subjects, who were exposed to very high altitude (5260 m), low barometric pressure (406 mmHg), and hypobaric hypoxia (VLH) at various timepoints. We found that exposure to VLH activated gene expression in leukocytes, resulting in an inverted CD4/CD8 ratio that interacted with other phenotypic risk factors at the genetic level. A total of 2286 underlying risk genes were input into the support vector machine recursive feature elimination (SVM-RFE) system for machine learning, and a model with satisfactory predictive accuracy and clinical applicability was established for sAMS screening using ten featured genes with significant predictive power. Five featured genes (EPHB3, DIP2B, RHEBL1, GALNT13, and SLC8A2) were identified upstream of hypoxia- and/or inflammation-related pathways mediated by microRNAs as potential biomarkers for sAMS. The established prediction model of sAMS holds promise for clinical application as a genetic screening tool for sAMS.

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End-Tidal Partial Pressure of Carbon Dioxide and Acute Mountain Sickness in the First 24 Hours Upon Ascent to Cusco Peru (3326 meters)

Cited by 7 publications

References 11 publications

Characteristics of Headache at Altitude among Trekkers; A comparison between Acute Mountain Sickness and Non-Acute Mountain Sickness Headache

Characteristics of Headache at Altitude among Trekkers; A comparison between Acute Mountain Sickness and Non-Acute Mountain Sickness Headache

Does a change in end-tidal carbon dioxide level predict high altitude mountain sickness?

Establishing a prediction model of severe acute mountain sickness using machine learning of support vector machine recursive feature elimination

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