Endemic Cretinism and Deaf-Mutism

Deutsch, M. U.

doi:10.1016/s0140-6736(60)91846-8

Cited by 2 publications

(2 citation statements)

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“…Trotter ( 1 ) has pointed out that three forms of thyroid disease have been repeatedly observed in association with hearing deficits: myxedema in the adult (2); endemic cretinism (3,4); and Pendred's syndrome (5,6). The hearing loss in adult myxedema may be perceptive, conductive, or both, but it is usually not severe and can be improved with exogenous thyroid hormone replacement.…”

Section: Introductionmentioning

confidence: 99%

Otic Lesions and Congenital Hypothyroidism in the Developing Chick*

Bargman¹,

Gardner²

1967

J. Clin. Invest.

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Abstract. In an effort to elucidate the relation, if any, between thyroid abnormality and congenital deafness in Pendred's syndrome, an experiment was designed to study the effects of hypothyroidism on middle and inner ear hearing structures, including the auditory nerve and its central projection, in developing chick embryos. Propylthiouracil (PTU), 2 mg, was injected into the albumin of fertile chick eggs on the 10th incubation day. Single doses of L-thyroxine (range 1-100,ug) were inoculated in a similar manner, either alone or with PTU. Control inocula included sterile saline or water. After hatching, each chick was examined for obvious malformations. The thyroid glands, middle and inner ear mechanisms, auditory nerve, and brainstem were studied grossly and with different histologic staining techniques. When compared to controls, chicks exposed to PTU on their 10th incubation day exhibited: increased mortality, delayed hatching, reduced size, incomplete yolk sac absorption, and death within 5 days unless exogenous thyroid hormone was provided in the first 24-48 hr after hatching. Specific, consistent, morphologic alterations were observed in their thyroid glands as well as in the sensory hair cells of the acoustic papilla and cells of the spiral ganglion of the cochlea. Our data also indicate that if 50-75 fug of L-thyroxine is given simultaneously with (or as long as 120 hr after) the PTU injection on the 10th incubation day, one cannot detect the gross defects, marked thyroid lesions, or abnormal histology in cells of the cochlea and its ganglion. A relationship between embryonic thyroid gland function and the hearing mechanism of the chick embryo is suggested.

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Section: Introductionmentioning

confidence: 99%

Otic Lesions and Congenital Hypothyroidism in the Developing Chick*

Bargman¹,

Gardner²

1967

J. Clin. Invest.

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“…Bu itibarla hekimin özen yükümlülüğünü ihlali, bir müdahaleyi gerekli olduğu şekilde yapmaması şeklin-de söz konusu olabileceği gibi, gerekli müdahaleyi hiç yapmaması şeklinde de olabilir 22 . Dolayısıyla hareketin icrai veya ihmali olması arasında bir fark gözetilme-mekte, her ikisi de aynı nitelikte kabul edilmektedir 23 .…”

Section: Genel Olarak Tip Hukukunda Sorumlulukunclassified

Distinction between malpractice and complication in medical law

Hakeri¹

2014

Toraks Cer Bult

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One of the essential topics of medical law is the distinction between malpractice and complication. Healt workers are responsible because of malpractice but not because of complication. The problem is how it is to differentiate between malpractice and complication. Health workers would like to see also predictable results of medical intervention as malpractice, whereas the jurists don't accept it as malpractice, if health worker is guilty.

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Endemic Cretinism and Deaf-Mutism

Cited by 2 publications

References 1 publication

Otic Lesions and Congenital Hypothyroidism in the Developing Chick*

Otic Lesions and Congenital Hypothyroidism in the Developing Chick*

Distinction between malpractice and complication in medical law

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