Endemic Hantavirus in Field Voles, Northern England

Thomason, Anna G.; Begon, Michael; Bradley, Janette E.; Paterson, Steve; Jackson, Joseph A.

doi:10.3201/eid2306.161607

Cited by 13 publications

(9 citation statements)

References 9 publications

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“…Later, TULV was also isolated from the vole samples collected in the central European countries [ 59 ]. A novel vole-associated hantavirus related to TULV and PUUV, Tatenale virus (TATV), has been identified in field voles ( Microtus agrestis ) captured in different parts of England [ 60 , 61 ]. This virus is believed to be non-pathogenic in humans and rodents [ 62 ].…”

Section: Distribution Of Orthohantaviruses and The Diseases They Cmentioning

confidence: 99%

Orthohantaviruses, Emerging Zoonotic Pathogens

et al. 2020

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Orthohantaviruses give rise to the emerging infections such as of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) in Eurasia and the Americas, respectively. In this review we will provide a comprehensive analysis of orthohantaviruses distribution and circulation in Eurasia and address the genetic diversity and evolution of Puumala orthohantavirus (PUUV), which causes HFRS in this region. Current data indicate that the geographical location and migration of the natural hosts can lead to the orthohantaviruses genetic diversity as the rodents adapt to the new environmental conditions. The data shows that a high level of diversity characterizes the genome of orthohantaviruses, and the PUUV genome is the most divergent. The reasons for the high genome diversity are mainly caused by point mutations and reassortment, which occur in the genome segments. However, it still remains unclear whether this diversity is linked to the disease’s severity. We anticipate that the information provided in this review will be useful for optimizing and developing preventive strategies of HFRS, an emerging zoonosis with potentially very high mortality rates.

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Section: Distribution Of Orthohantaviruses and The Diseases They Cmentioning

confidence: 99%

Orthohantaviruses, Emerging Zoonotic Pathogens

et al. 2020

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“…In addition, SEOV RNA was detected in 2011 & 2012 in brown rats (Rattus norvegicus) that were epidemiologically linked to 2 HF cases [5]. Furthermore, a novel vole-associated Hantavirus related to TULV & PUUV, Tatenale virus (TATV), was identified in North West England in 2013 [6] and again in Northern England in 2017 [7].…”

Section: Main Textmentioning

confidence: 99%

“…The two strains were 94.1%, 91.3% and 90.6% similar at the nucleotide level, across the S, M and L segments, respectively. The original phylogenies of B41 and Kielder strains of TATV were based on <400bp fragments of the L and S or L segment, respectively [6,7]. figure 1A-B) showed that both the Norton-Juxta and Upton-Heath strains clustered with TATV.…”

Section: Main Textmentioning

confidence: 99%

“…These findings extend the known range of TATV into central England and further strengthens the evidence of M. agrestis as a primary reservoir. TATV, or a TATV-like virus, has been suggested as a possible causative agent of HF in the United Kingdom [7]. However, the paucity of sequence data has precluded significant investigation.…”

Section: Analysis Of the Corresponding L And S Sequences (Supplementarymentioning

confidence: 99%

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Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports its Classification as a Novel Species

Chappell

Tsoleridis

Onianwa

et al. 2019

Preprint

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Hantaviruses are a diverse group of single-stranded, negative-sensed RNA viruses, known to cause sporadic outbreaks of potentially fatal human disease. To date, only two Orthohantavirus species have been detected in the UK - Seoul virus and Tatenale. Whilst Seoul is known to be pathogenic in humans, only partial fragments of Tatenale have been recovered, precluding any accurate analysis of its phylogeny or potential pathogenicity. To overcome this shortfall we used a degenerate primer PCR method to identify Tatenale-infection in rodents living in two separate locations in the UK. PCR positive samples were then subjected to either unbiased high-throughput sequencing or overlapping PCR product sequencing to recover the complete coding sequence of the Tatenale virus. This analysis provided in-depth insight into the evolutionary origins of this recently identified UK Orthohantavirus and unequivocally showed that Tatenale virus meets the established criteria for classification as a novel species. Crucially, our data will facilitate in vitro investigation into the zoonotic potential of Tatenale virus.

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“…The first orthohantavirus linked to HF in the UK was in 2011 when a novel strain of SEOV was isolated from wild rats captured on the farm of a patient with suspected HF [18]; SEOV was then detected in pet rats belonging to a patient with serologically confirmed HF in 2013 [19]. Furthermore, a novel vole-associated hantavirus related to TULV and PUUV-Tatenale virus (TATV)-was identified in field voles (Microtus agrestis) captured in northwest England in 2013 [20] and again in northern England in 2017 [21]. However, fragments of less than 400 nucleotides were retrieved for two of the three genomic segments, meaning that phylogenetic analysis of this virus was limited.…”

Section: Introductionmentioning

confidence: 99%

Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species

Chappell

Tsoleridis

Onianwa

et al. 2020

Viruses

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Orthohantaviruses are globally distributed viruses, associated with rodents and other small mammals. However, data on the circulation of orthohantaviruses within the UK, particularly the UK-endemic Tatenale virus, is sparse. In this study, 531 animals from five rodent species were collected from two locations in northern and central England and screened using a degenerate, pan- orthohantavirus RT-PCR assay. Tatenale virus was detected in a single field vole (Microtus agrestis) from central England and twelve field voles from northern England. Unbiased high-throughput sequencing of the central English strain resulted in the recovery of the complete coding sequence of a novel strain of Tatenale virus, whilst PCR-primer walking of the northern English strain recovered almost complete coding sequence of a previously identified strain. These findings represented the detection of a third lineage of Tatenale virus in the United Kingdom and extended the known geographic distribution of these viruses from northern to central England. Furthermore, the recovery of the complete coding sequence revealed that Tatenale virus was sufficiently related to the recently identified Traemersee virus, to meet the accepted criteria for classification as a single species of orthohantavirus.

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Endemic Hantavirus in Field Voles, Northern England

Cited by 13 publications

References 9 publications

Orthohantaviruses, Emerging Zoonotic Pathogens

Orthohantaviruses, Emerging Zoonotic Pathogens

Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports its Classification as a Novel Species

Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species

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