Endemic Kaposi's Sarcoma in Human Immunodeficiency Virus Type 1–Seronegative Persons: Demonstration of Retrovirus-Like Particles in Cutaneous Lesions

Rappersberger, Klemens; Tschachler, Erwin; Zonzits, Eva; Gillitzer, R.; Hatzakis, Angelos; Kaloterakis, A; Mann, Dean L.; Popow-Kraupp, Theresa; Biggar, Robert J.; Berger, Rudolf; Stratigos, J.; Wolff, Klaus; Stingl, Georg

doi:10.1111/1523-1747.ep12555450

Cited by 64 publications

(24 citation statements)

References 46 publications

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“…clustering of cases in Africa (Beral et al, 1990), faecal-oral contact as main route of transmission in homosexual and bisexual men ], a number of infectious agents [e.g. cytomegalovirus , mycoplasma (Lo, 1986), retrovirus-like agents (Rappersberger et al, 1990)] have been proposed as the cause but never substantiated. To this extent, it is of interest that history of malaria was reported in nine out of 17 patients with KS studied in detail in Sicily (Gafi et al, 1984) and that a decline was apparent in men aged 50 years or older over recent years.…”

Section: Discussionmentioning

confidence: 99%

Kaposi's sarcoma in Italy before and after the AIDS epidemic

Geddes¹,

Franceschi

Barchielli

et al. 1994

Br J Cancer

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The incidence of Kaposi's sarcoma (KS) in 1976-90 was assessed in Italy, taking advantage of a network of nine population-based cancer registries covering, at its maximum, approximately 5.6 million subjects. The first examined period (1976-84) substantially reflects the epidemiology of KS prior to the AIDS epidemic in the registration areas. Elevated incidence rates, standardised to the Italian population of 1981, of 1.05/100,000 men and 0.27/100,000 women emerged in 1976-84 (i.e. from two- to threefold higher than in the USA and Sweden, more than tenfold higher than in England and Wales). These high rates, especially remarkable in the Registry from the south of Italy (i.e. Ragusa, 3.01/100,000 men and 0.54/100,000 women) suggest that the prevalence of the still unknown causative agent for KS was high, at least in some parts of Italy, prior to the AIDS epidemic. In the most recent period (1985-90), an approximately twofold increase in KS incidence rates in Italian men below age 50 was observed (from 0.15 in 1976-84 to 0.47 in 1985-90). Conversely, declines in KS incidence were recorded in older men.

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Section: Discussionmentioning

confidence: 99%

Kaposi's sarcoma in Italy before and after the AIDS epidemic

Geddes¹,

Franceschi

Barchielli

et al. 1994

Br J Cancer

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show abstract

“…The staining (observed by sorne Iaboratories but not by others) of spindIe celIs with antibodies to CD 14, CD68 and factor XIIIa has been interpreted to reflect a possible lInk between Kaposi' s sarcoma spindle cells and celIs of the monocyte/macrophage Iineage, possibly dermaI dendrocytes (NickoIoff et al, 1989;Rappersberger et al, 1991;Kaaya et aL., 1995). These cells are distinct from Langerhans' cells (Nickoloff et al, 1989).…”

Section: Time Of Onset Of Cancers In Non-hiv-associated Immunodeficiencymentioning

confidence: 98%

“…Roth et al, 1992;Stürzl et al, 1992a;Kaaya et aL., 1995). Rappersberger et al (1991) reported that spindIe cells stain with the monoclonal antibody EN-4 (which detects both vascular and lymphatic endothelium) but Iack reactivity with the monoclonal antibody Pal-E (which reacts with blood-vessel but not 1ymphatic endothelial cells). This observation is compatible with spindle cells originating from Iymphatic endothelium.…”

Section: Time Of Onset Of Cancers In Non-hiv-associated Immunodeficiencymentioning

confidence: 99%

“…OKM-5 and anti-factor VlII-related antigen; von Willebrand factor; vWF) stain Kaposi's sarcoma endotheliaI or spindle cells, although slightIy varying results have been reported by different Iaboratories (Nadji et al, 1981;Modlin et al, 1983a;Little et al, 1986;Rappersberger et al, 1991; further references in Roth et al, 1992).…”

Section: Time Of Onset Of Cancers In Non-hiv-associated Immunodeficiencymentioning

confidence: 99%

“…Ultrastructurai examination has faiIed to show the presence of Weibe1-Palade bodies, the storage vesicles for vWF and therefore a characteristic feature of vascular endotheIium, in spindle cells from Kaposi' s sarcoma lesions (Rappersberger et al, 1991). Staining with monoclonal antibody BMA 120, that detects an antigen specific to endotheliaI cells, Iends support to an endotheliaI origin of Kaposi's sarcoma cells (Roth et aL., 1988).…”

Section: Time Of Onset Of Cancers In Non-hiv-associated Immunodeficiencymentioning

confidence: 99%

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