Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review

Muhsen, Ibrahim N.; Galeano, Sebastián; Niederwieser, Dietger; Koh, Mickey; Ljungman, Per; Machado, Clarisse Martins; Kharfan‐Dabaja, Mohamed A.; Cámara, Rafael de la; Kodera, Yoshihisa; Szer, Jeff; Rasheed, Walid; Cesaro, Simone; Hashmi, Shahrukh K.; Seber, Adriana; Atsuta, Yoshiko; Saleh, Mahasen; Srivastava, Alok; Styczyński, Jan; Alrajhi, Abdulrahman A.; Almaghrabi, Reem S.; Abid, Muhammad Bilal; Chemaly, Roy F.; Gergis, Usama; Brissot, Éolia; Fakih, Riad El; Riches, Marcie L.; Mikulska, Małgorzata; Worel, Nina; Weisdorf, Daniel J.; Greinix, Hildegard; Cordonnier, Catherine; Aljurf, Mahmoud

doi:10.1016/s2352-3026(23)00031-5

Cited by 12 publications

(15 citation statements)

References 65 publications

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“…One crucial aspect is to adapt the teaching curriculum to the reality of our region. Besides acquiring knowledge and expertise about all aspects of HCT/CT, transplant physicians must be aware of the particularities of patients and donors from our countries, such as endemic infections, dengue, Zika, yellow fever, chikungunya, Chagas disease, tuberculosis, malaria, etc 41 . Also, the Latin American transplant physician needs to learn how to deal with a lack of access to good-quality public services and water, poor nutritional stage, low educational levels, and financial problems of coverage and reimbursement for the procedure and medication 42 .…”

Section: Labmt Perspectivementioning

confidence: 99%

Fostering next generation transplant physicians

2024

BCT

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As opposed to the rapid expansion of hematopoietic cell transplantation (HCT) and other cellular therapies (CT), we are now facing a global shortage of transplant physicians and other professionals to support the activity of HCT/CT. To overcome this obstacle, a variety of approaches are now being undertaken in four international HCT societies. This article aims to share their current attempts to foster the next generation of transplant physicians and allied professionals needed to secure the continued global growth of HCT/CT.

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Section: Labmt Perspectivementioning

confidence: 99%

Fostering next generation transplant physicians

2024

BCT

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“…Receiving anti-parasitic treatment for T. cruzi prior to transplantation for transplant recipients suffering from CD does not necessarily reduce the risk of reactivation but might be considered on an individual basis [ 76 , 77 ]. Reactivation of CD has also been reported in bone marrow transplants, monitoring of CD and consideration of preemptive therapy might be considered [ 78 , 79 , 80 ].…”

Section: Transfusion and Transplant-associated T Cruzi ...mentioning

confidence: 99%

Chagas Disease in Europe

Gonzalez-Sanz,

Crespillo-Andújar,

Chamorro-Tojeiro

et al. 2023

TropicalMed

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Chagas disease is currently present in many non-endemic countries and remains a neglected tropical disease globally. A review of the literature identified significant gaps and scarcity of updated information from European countries, with most studies reporting data from Spain and Italy. The index of underdiagnosis may be as high as 70%, affecting mainly females of child-bearing age. Standardized screening of fertile, non-pregnant, women from endemic countries and subsequent treatment is considered an essential strategy to control transmission and prevent new cases, yet no uniform legislation for screening risk groups exists. There is heterogeneity in Europe in terms of preventive strategies to avoid transfusion-related transmission of Chagas disease, not necessarily in line with the European directives, with some countries conducting systematic screening for T. cruzi infection in blood donors, whilst others rely on pre-transfusion questionnaires. The growing burden of the infection in resource-rich areas may provide an opportunity for progress in certain aspects of control and prevention. Options for improving screening strategies, management and linkage to care are reviewed.

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“…91 Mortality rates of this hyperinfection syndrome are estimated to be as high as 83% in HCT recipients. 92 Pulmonary strongyloidiasis can present as a fever and cough but progress to severe respiratory failure and septic shock. Peripheral eosinophilia may be absent in the setting of immunosuppression.…”

Section: Strongyloidiasismentioning

confidence: 99%

“…94 Acute strongyloidiasis can be detected using the same serologic tests and direct microscopic visualization on sputum, BAL, or stool samples. 92…”

Section: Strongyloidiasismentioning

confidence: 99%

Evaluation of pulmonary abnormalities in recipients of hematopoietic cell transplants and cellular therapies

Thomas,

Boatman

2023

Transplant Infectious Dis

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Hematopoietic cell transplant (HCT) and chimeric antigen receptor T‐cell (CAR‐T) therapy recipients are susceptible to multiple pulmonary complications that are caused by infectious and noninfectious processes. Numerous variables can be associated with specific pulmonary diseases including time from transplantation, presence of graft versus host disease (GVHD), underlying disease, and prolonged neutropenia and lymphocytopenia. Most pulmonary complications are infectious in origin, with bacterial pneumonia remaining the most common pulmonary infection, particularly before neutrophil engraftment. Invasive fungal infections continue to affect this patient population even when antifungal prophylaxis is used. Noninfectious pulmonary complications include a wide differential of pathologies in this population, and as clinical presentations of these various pulmonary disorders often overlap, clinicians frequently will use a multidisciplinary approach in diagnosing these abnormalities. Radiography, particularly with chest computed tomography (CT) imaging, is an essential tool in identifying pulmonary pathology and potential sources. While standard microbiological cultures of respiratory specimens are still utilized, their role is limited by low sensitivity and diagnostic yield. The likelihood of obtaining a diagnosis can be improved by using other microbiological assays, including fungal antigen tests and molecular diagnostic methods, particularly if specimens are collected via bronchoscopy. This review will highlight the more common causes of pulmonary diseases encountered after HCT and CAR‐T and will examine the different methods in their diagnosis.

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Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review

Cited by 12 publications

References 65 publications

Fostering next generation transplant physicians

Fostering next generation transplant physicians

Chagas Disease in Europe

Evaluation of pulmonary abnormalities in recipients of hematopoietic cell transplants and cellular therapies

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