Endemic pemphigus foliaceus (fogo seivagem). I. Clinical features and immunopathology

Díaz, Luis A.; Sampaio, S. A. P.; Rivitti, Evandro A.; Martins, Camila Bertini; Cunha, Paulo Rowilson; Lombardi, Clovis; Almeida, Fernando Augusto de; Castro, R. M.; Macca, Mario L.; Lavrado, Carlos; Filho, Gunther H.; Borges, Paulo César; Minelli, Lorivaldo; Empinotti, Julio C.; Friedman, Horácio; Campbell, Iphis; Labib, Ramzy S.; Anhalt, Grant J.

doi:10.1016/s0190-9622(89)70079-7

Cited by 159 publications

(115 citation statements)

References 36 publications

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“…Endemic pemphigus foliaceus (EPF) is an autoimmune blistering skin disease presenting in well-defined geographic regions [1][2][3][4][5][6][7]. The roles of IgG autoantibodies and complement in lesional EPF skin has been previously documented [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Mast cells, Mast/Stem Cell Growth Factor receptor (c-kit/cd117) and IgE may be integral to the pathogenesis of endemic pemphigus foliaceus

Velez¹,

Roselino²,

Howard³

2013

Our Dermatol Online

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Introduction: Pemphigus foliaceus (PF) is endemic in some South American countries, especially in Colombia and Brazil; in Brazil, it is also known as fogo selvagem (FS). We aimed to study the presence of mast cells and the expression of the mast/stem cell growth factor receptor (c-kit/CD117) in PF skin biopsies, as well as the role of IgE in the disease pathogenesis. Methods: Forty-four skin biopsies from patients affected by endemic PF (EPF) (30 patients from El Bagre, Colombia, and 14 from the northeastern region of São Paulo State, Brazil), 48 control biopsies from Colombian and Brazilian endemic areas, and additional control biopsies from none endemic areas in Colombia and the USA non were studied. Immunohistochemistry (IHC) was performed to evaluate skin biopsies with anti-mast cell tryptase (MCT), anti-c-kit and anti-IgE antibodies. We also searched for serum IgE in 30 EPF and 30 non-atopic controls from the El Bagre region via ELISA. In our El Bagre patients and controls, we also searched for IgE in skin samples by direct immunofluorescence. Results: In 100% of the EPF biopsies, MCT, c-kit and IgE were identified with stronger expression relative to control biopsies, especially in the inflammatory infiltrates around upper dermal blood vessels and dermal eccrine glands. IgE staining was positive along the BMZ in some EPF skin samples. The DIF results confirmed a linear deposition of IgE at the BMZ. Increased IgE serum levels were also noted in PF patients relative to controls.. Conclusions:In patients with EPF, the observed increased expression of MCT, c-kit and IgE in lesional skin, associated with higher serum IgE levels may indicate possible IgE participation in the antigenic response.

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Section: Introductionmentioning

confidence: 99%

Mast cells, Mast/Stem Cell Growth Factor receptor (c-kit/cd117) and IgE may be integral to the pathogenesis of endemic pemphigus foliaceus

Velez¹,

Roselino²,

Howard³

2013

Our Dermatol Online

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“…Trata-se de Sinal clássico, bem caracterizado em casos de pênfigo foliáceo humano, na modalidade endêmi-ca ("pênfigo brasileiro" ou "sul-americano" ou, ainda, fogo-selvagem) (DIAZ et al, 1989;FURTADO, 1959). Foi referido, de forma magistral, por Vieira (1948), dermatologista brasileiro, na fase de evolução para a cura da enfermidade, denominada "aurora da cura".…”

Section: Salpico De Lamaunclassified

“…Canino penfigoso no pós-terapia Fonte: (LARSSON, 2014) Figura 27 -Pênfigo foliáceo -lesões ventrais, na pré-terapia de pênfigo foliáceo canino. Aspecto pustular erosado (configuração circinada) disseminado em área abdominal ventral e úmero-radio-ulnar (canino da figura 26) Fonte: (LARSSON, 2014) Histologicamente, há proliferação melanocítica intraepidérmica e consequente aumento da deposição melânica, incontinência pigmentar com acúmulo de melanina nos fagócitos dérmicos (DIAZ et al, 1989).…”

Section: Salpico De Lamaunclassified

Sinais dermatológicos clássicos na medicina veterinária

Larsson

2014

Braz. J. Vet. Res. Anim. Sci.

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ResumoArrolam-se os sinais dermatológicos evidenciados na rotina da clínica dermatológica, que permitem aventar um diagnóstico presuntivo ou até estabelecê-lo cabalmente. Os dezesseis sinais reunidos envolvem quadros dermatopáticos etiologicamente relacionados às enfermidades autoimunes, infecciosas, parasitárias, alérgicas, endócrinas, psicopáticas, disqueratinizantes, neoplásicas e genodermatósicas. Palavras-chave:Sinal. Semiogênese. Dermatites. Dermatoses. AbstractDermatological signals observed in routine dermatologic clinical practice, which allow producing any presumptive diagnosis or to establish it fully, are listed. The 16 signals gathered are related to autoimmune, infectious, parasitic, allergic, endocrine, psychopathic, neoplasic, genetic and of abnormal cornification diseases. Keywords:Signal. Semiogenesis. Dermatitis. Dermatosis. Sinais dermatológicos clássicos na medicina veterinária Classic dermatological signs in veterinary medicine IntroduçãoOs objetivos desse artigo foram compulsar e caracterizar os sinais dermatológicos além de facilitar a interlocução entre clínicos veterinários, mormente os dermatológos, sobre uma plêiade de manifestações, clinicamente evidenciáveis, que povoam o conhecimento dermatológico. Com grande frequência, o clí-nico confronta-se com epônimos, sinais ou mesmo síndromas cujo significado não se explicita de per se em sua designação (SAMPAIO; RIVITTI, 2007).Há pouco tempo, no seio da medicina veterinária, à medida que se anglicizam os textos clínicos, abandonando-se a escola europeia, tradicional e vetusta, e abraçando-se o denominado americanismo ou americanização da semiotécnica, o termo "sinal" passou a substituir a clássica terminologia "sintoma" 1 , ou seja, os animais não mais teriam sintomas, mas, sim, simplesmente, sinais clínicos! Embora tradicionais semiológos médicos brasileiros, tais como o goiano Porto (2011) na sexta edição de seu tratado "Semiologia Médica", de 2011, considera que se possa utilizá-los como termos sinonímicos, também ressalta aquele tratadista que não são elas expressões exatamente sinônimas, por mais que sejamos tentados a igualá-las.Ao longo deste artigo, considerar-se-á sinal a expressão que, segundo o destacado semiólogo veterinário brasileiro Eduardo Harry Birgel, docente com formação germânica, aposentado pela Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo, tão bem caracterizou, ao longo de suas preleções e escritos, com o significado de "manifesta-1 Do grego: súmptõma, atos. Do latim medieval: symptoma, ãtis -sintoma (1661). Do

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“…3) (Eyre and Stanley, 1988). It is still a paradox, therefore, that pemphigus vulgaris antibodies, in spite of their broader binding capacity, cause loss of cell adhesion at only the suprabasal level, and that pemphigus foliaceus patients, in whom mucosal lesions rarely occur, show in vivo-bound autoantibodies in oral and esophageal mucosa (Diaz et al, 1989). The recent demonstration of antibodies to desmosomal plaque proteins in both pemphigus vulgaris and pemphigus foleaceus patients, however, may explain these staining patterns The intercellular localization of this antigen (from 180 to 190 kDa) does not favor inclusion of anti-180-to 190-kDa antibodies among pathogenic pemphigus autoantibodies, but they will nevertheless produce staining in indirect immunofluorescence staining (loly et al, 1994 (Rock et al, 1989;Allen et al, 1993;Calvanico et al, 1993;Bhol et al, 1995).…”

Section: Immunopathologymentioning

confidence: 99%

Molecular Biological Aspects of Acquired Bullous Diseases

Dabelsteen

1998

Critical Reviews in Oral Biology & Medicine

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Bullous diseases of the oral mucosa and skin were originally classified on the basis of clinical and histological criteria. The discovery of autoantibodies in some of these patients and the introduction of molecular biology have resulted in a new understanding of the pathological mechanisms of many of the bullous lesions. In this article, updated topics of the immune-mediated bullous lesions which involve oral mucosa and skin are reviewed. Pemphigus antigens, which are desmosomal-associated proteins and belong to the cadherin superfamily of cell adhesion proteins, have been isolated, and their genes have been cloned. The antigens which react with autoantibodies from patients with bullous pemphigoid, cicatricial pemphigoid, acquired epidermolysis bullosa, and linear IgA disease are all proteins of the hemidesmosome basement membrane complex. Interestingly, most of the antigens also appear to be the target for mutations seen in patients with the inherited type of epidermolysis bullosa in which bullous lesions are a prominent clinical feature.

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Endemic pemphigus foliaceus (fogo seivagem). I. Clinical features and immunopathology

Cited by 159 publications

References 36 publications

Mast cells, Mast/Stem Cell Growth Factor receptor (c-kit/cd117) and IgE may be integral to the pathogenesis of endemic pemphigus foliaceus

Mast cells, Mast/Stem Cell Growth Factor receptor (c-kit/cd117) and IgE may be integral to the pathogenesis of endemic pemphigus foliaceus

Sinais dermatológicos clássicos na medicina veterinária

Molecular Biological Aspects of Acquired Bullous Diseases

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