Endemic Plants: From Design to a New Way of Smart Hybrid Nanomaterials for Green Nanomedicine Applications

Haddada, Maroua Ben; Gerometta, Elise; Bialecki, Anne; Fu, Weiling; Zhang, Yang; Chapelle, Marc Lamy de la; Djaker, Nadia; Pesnel, Sabrina; Morel, Anne-Laure; Spadavecchia, Jolanda

doi:10.4172/2157-7439.1000518

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…26 They appeared as relevant candidates for the thermal destruction of tumours by light therapy. 26,29,30 Consequently, these results prove in a forehand that this method consists in a physical mechanism of action, independent of the cell lines. Based on the accumulation of the photosensitizer agent into the tumour, the AuNPs will act as an antenna to receive the stimulation and convert the energy into heat only located in the cells that internalized the nanoparticles.…”

Section: Introductionmentioning

confidence: 53%

“…Our previous studies performed on melanoma murine model constitutes the proof of concept of effective photothermal therapy mediated by our AuNPs 26 . They appeared as relevant candidates for the thermal destruction of tumours by light therapy 26,29,30 . Consequently, these results prove in a forehand that this method consists in a physical mechanism of action, independent of the cell lines.…”

Section: Introductionmentioning

confidence: 61%

“…The AuNPs were synthesized using the method previously described. [30][31][32][33] An aliquot of AuNP solution was mixed with the same volume of D-glucose under vigorous stirring for 1 h at room temperature in the absence of light. The solution was centrifuged and redispersed in 0.9% NaCl.…”

Section: Synthesis Of Aunpsmentioning

confidence: 99%

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Plasmonic nanophotothermal therapy for the treatment of basal cell carcinoma with gold nanoparticles

Pesnel,

Ben Haddada,

Duquenne

et al. 2023

JEADV Clinical Practice

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BackgroundBasal cell carcinoma (BCC) is the most common form of skin cancer, typically developing in sun‐exposed areas such as the face. Surgery is the treatment of choice, with a overall good prognosis. However, some scars can be unsightly or bothersome, and some tumours are too large or badly located to be eligible for surgery. Plasmonic photothermal therapy is presented here as an alternative treatment. Our team has developed green gold nanoparticles that have demonstrated their efficacy in inducing hyperthermia in the tumour‐microenvironment when combined with near‐infrared laser (NIR laser).ObjectivesThe aim of this study is to demonstrate the effectiveness of gold nanoparticles combined with laser treatment against BCC.MethodsIn vitro, BCC cells were exposed to gold nanoparticles, both with and without laser treatment, to study the effects of this therapy on skin cells. Subsequently, mice bearing BCC were treated with photothermal therapy to assess tumour growth.ResultsGold nanoparticles were found to be nontoxic to the cell line, and photothermal therapy induced apoptosis. In vivo studies showed complete regression of tumours without unsightly scarring and no recurrence after 40 days.ConclusionPlasmonic photothermal therapy using gold nanoparticles proved its efficacy in the destruction of BCC.

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Section: Introductionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 61%

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Plasmonic nanophotothermal therapy for the treatment of basal cell carcinoma with gold nanoparticles

Pesnel,

Ben Haddada,

Duquenne

et al. 2023

JEADV Clinical Practice

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“…Research on nanoparticles has focused on the development of new strategies for synthetizing AuNPs such as a green chemistry approach resulting in greater stability and lower toxicity in vivo [13]. It has been established that AuNPs injected in a tissue can be captured by professional antigen-presenting cells (APCs) mostly lymph node-resident dendritic cells (LN-resident DCs) [18,19].…”

Section: Discussionmentioning

confidence: 99%

“…However, nanoparticle-cell interactions could trigger oxidative stress and inflammatory cytokine cascade activation once AuNPs have been incorporated into the cell via the endocytic pathway [11]. To prevent such effects, the current researches have focused on the development of innovative manufacturing processes to reduce AuNP toxicity such as environmental-friendly approaches [12,13].…”

Section: Introductionmentioning

confidence: 99%

The Gold Nanoparticles-Functionalized with the Synthetic PADRE^S2P6 Peptide Can Be Useful for SARS-CoV-2 Detection

Herrscher,

Ben Haddada,

Andries

et al. 2023

Nanoarchitectonics

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Conjugation of bioactive peptides to nanomaterials is a promising approach for a variety of biomedical uses. Indeed, we assumed that gold nanoparticles (AuNPs) functionalized with synthetic viral peptides represent a promising strategy to elicit antibody response against zoonotic coronavirus SARS-CoV-2 responsible for pandemic COVID-19 disease. Two specific linear B-cell epitopes namely S1P4 and S2P6 have been recently identified in the SARS-CoV-2 spike protein expressed by the COVID-19 mRNA BNT162 vaccine of Pfizer-BioNTech and marketed under the brand name Comirnaty. The present study aimed at investigating the immunogenic potential of AuNPs functionalized with synthetic PADRE^S1P4 and PADRE^S2P6 peptides in a mouse model. The AuNPs were synthesized using an environmentally friendly process. In both synthetic PADRE^S1P4 and PADRE^S2P6 peptides, the SARS-CoV-2 spike antibody epitope is preceded by a polybasic sequence and the T-helper cell response activator PADRE. A thiol-terminated polyethylene glycol was used to decorate AuNP surface with the synthetic peptides. The AuNPs-peptide conjugates were inoculated without any adjuvant to adult BALB/c mice by intramuscular route in a prime-boost schedule. The AuNPs functionalized with the PADRE^S2P6 peptide but not the PADRE^S1P4 peptide were efficient to elicit antibody production of relevant specificity against the SARS-CoV-2 spike protein. The ability of PADRE^S2P6 peptide-reactive antibodies to recognize SARS-CoV-2 variants opens important perspectives for AuNP-peptide conjugates as potential serological tools to support the surveillance of wildlife-origin coronaviruses.

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Emerging Nanomaterial-Based Medications: Key Challenges and Opportunities

Reis

Oliveira

Payan-Carreira

2021

Bio-Manufactured Nanomaterials

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Endemic Plants: From Design to a New Way of Smart Hybrid Nanomaterials for Green Nanomedicine Applications

Cited by 7 publications

References 38 publications

Plasmonic nanophotothermal therapy for the treatment of basal cell carcinoma with gold nanoparticles

Plasmonic nanophotothermal therapy for the treatment of basal cell carcinoma with gold nanoparticles

The Gold Nanoparticles-Functionalized with the Synthetic PADRE^S2P6 Peptide Can Be Useful for SARS-CoV-2 Detection

Emerging Nanomaterial-Based Medications: Key Challenges and Opportunities

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