Endobronchial atypical mycobacteria in an immunocompetent child

Camacho, G del Rio; Guillén, L. Soriano; Aldeyturriaga, Javier Flandes; Garcia, Bradley; Borja, M. Bernácer

doi:10.1002/ppul.21194

Cited by 15 publications

(11 citation statements)

References 5 publications

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“…In the literature, MAC pulmonary diseases in children have generally been treated with various antibiotic regimens with variable outcome. Interestingly, a recent case reported a satisfactory outcome after removal of an isolated bronchoscopic endobronchial mass 6. In the present case, the clinical outcome was good as soon as the granulation was removed by laser section during the first bronchoscopy.…”

Section: Discussionsupporting

confidence: 47%

Endobronchial avium mycobacteria infection in an immunocompetent child

Périsson¹,

Nathan²,

Thierry³

et al. 2013

BMJ Case Reports

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A 12-month-old boy, with no medical history, was admitted for dyspnoea with no cough or fever. Chest auscultation revealed an expiratory wheezing with decreased right-sided breath sounds. Chest imaging revealed subcarinal adenopathy and a nodule in the right principal bronchus (RB). Bronchoscopy showed a major obstruction of the RB by a granuloma, and a smaller granuloma in the left principal bronchus. The granulation tissue was removed by laser section. Histological examination revealed a necrotising granulomatous inflammation, culture showed a Mycobacterium avium complex (MAC). Tests to rule out tuberculosis and immunodeficiency were negative. The diagnosis of an MAC endobronchial granuloma was ascertained and a multidrug therapy associating clarithromycin, rifampin and ethambutol was started. The clinical outcome was good after 3 months of treatment and the bronchoscopy normalised after 1 year. Although rare, the frequency of MAC respiratory infections in immunocompetent children can increase. Reporting these cases should help to optimise diagnosis and treatment.

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Section: Discussionsupporting

confidence: 47%

Endobronchial avium mycobacteria infection in an immunocompetent child

Périsson¹,

Nathan²,

Thierry³

et al. 2013

BMJ Case Reports

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“…Other reports describe the endobronchial masses caused by NTM to be fleshy, mucoid, cheesy friable or rubbery gray-white. 20,25,27,35,36 Most commonly, the lesions were characterized as granulation tissue, although 1 author 25 noted a caseous node. In all our cases, endobronchial masses significantly obstructed a large bronchus; after debulking, an intact bronchial wall was found.…”

Section: Discussionmentioning

confidence: 98%

Endobronchial Lesions Caused by Nontuberculous Mycobacteria in Apparently Healthy Pediatric Patients

Kröner

Griese²,

Kappler³

et al. 2015

Pediatric Infectious Disease Journal

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Pulmonary disease caused by nontuberculous mycobacteria in healthy children is rare, and its pathogenesis is unknown in most cases and standardized treatment is lacking. Here, we report various endobronchial manifestations in 5 patients including hitherto undescribed diffuse tracheobronchial granulomas in 2 patients. Bronchoscopic debulking was performed in all patients and tuberculostatic treatment in 4. All patients including 1 without tuberculostatic treatment showed remission.

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“…30 Nontuberculous mycobacteria such as mycobacterium avium can also cause endobronchial granulomas and has been reported even in immunocompetent children. 31 Fibrosing mediastinitis, also known as mediastinal fibrosis or sclerosing mediastinitis, is characterized by abnormal proliferation of acellular collagen and fibrous tissue in the mediastinum. Symptoms are related to obstruction and compression of mediastinal structures including large airways.…”

Section: Large Airway Infectionsmentioning

confidence: 99%