Endobronchial Injection of Botulinum Toxin for the Reduction of Bronchial Hyperreactivity Induced by Methacholine Inhalation in Dogs

Al-Halfawy, Ahmed; Gomaa, Nada E.; Refaat, Ahmed; Wissa, Marian Youssry; Wahidi, Momen M.

doi:10.1097/lbr.0b013e318271179e

Cited by 6 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( 13 , 14 ) There are eight different, antigenically distinct serotypes of Clostridium botulinum . ( 15 ) The most commonly used and studied serotype is botulinum toxin A, and achalasia studies have used it exclusively. However, botulinum toxin B is also commercially available.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of botulinum toxin injection therapy for esophageal achalasia in Japan

Yamaguchi

Tsuruoka

Sakata

et al. 2015

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

Botulinum toxin injection is an accepted treatment modality for esophageal achalasia in western countries. This pilot study aimed to clarify the effectiveness of botulinum toxin injection for esophageal achalasia in Japanese patients. We enrolled 10 patients diagnosed with esophageal achalasia between 2008 and 2014. A total of 100 U botulinum toxin A was divided into eight aliquots and injected around the esophagogastric junction. We compared the lower esophageal sphincter pressure before and 1 week after treatment. Scores of subjective symptoms for esophageal achalasia were assessed using a visual analog scale (VAS) before and after 1 week of follow-up of treatment. Barium passage was improved in barium esophagography and passage of contrast agent was also improved. Mean Eckardt score was reduced from 5.5 to 1.6 after treatment (p<0.001). By esophageal manometric study, mean lower esophageal sphincter pressure was reduced from 46.9 to 29.1 mmHg after treatment (p = 0.002). One week after treatment, mean VAS score was reduced from 10 to 3.9 (p<0.001). There were no side effects in any cases. Botulinum toxin injection for esophageal achalasia was safe and effective with few complications. Therefore, botulinum toxin could be used as minimally invasive therapy for esophageal achalasia in Japan.

show abstract

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of botulinum toxin injection therapy for esophageal achalasia in Japan

Yamaguchi

Tsuruoka

Sakata

et al. 2015

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

show abstract

Section: Therapeutic Applications In Veterinary Medicinementioning

confidence: 99%

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

Turin,

Piccione,

Crosa

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

Botulinum neurotoxins (BoNTs) are emerging as multipurpose therapeutic compounds for the treatment of several different syndromes involving peripheral and central nervous systems, and muscular and musculoskeletal disorders both in human and veterinary medicine. Therefore, the study of BoNTs is rapidly developing and identifying newly produced BoNT variants. Efforts should be made to clarify the biological and pharmacological characteristics of these novel BoNTs as well as the natural ones. The high potential of BoNTs as a therapeutic compound for medical syndromes lies in its ability to reach a specific cell type while bypassing other cells, thus having mild or no side effects. In this paper the recent developments in BoNTs are reviewed with the aim of analyzing the current knowledge on BoNTs’ biological mechanisms of action, immunogenicity, formulations, and therapeutic applications in the veterinary field, highlighting advantages and drawbacks and identifying the gaps to be filled in order to address research priorities.

show abstract

“…An experimental study to reduce bronchial hyperreactivity in dogs tested the effect of BoNT-A submucosal injections into the caudal lobe bronchus. Local injections of BoNT-A resulted in a reduction of about 60% of the bronchial hyper-responsiveness, chemically induced to mimic asthma, in a canine model for up to 6 months [69]. All studies on canine patients demonstrate that BoNT-A treatments bring remarkable clinical improvement to diseases lacking efficacious treatments and characterized by high morbidity and poor quality of life.…”

mentioning

confidence: 93%

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

Turin,

Piccione,

Crosa

et al. 2023

Preprint

View full text Add to dashboard Cite

Botulinum neurotoxins (BoNTs) are emerging as multipurpose therapeutic compounds for the treatment of several different syndromes involving peripheral and central nervous systems, and muscular and musculoskeletal disorders both in human and veterinary medicine. Therefore, the studies of BoNTs are rapidly developing and identifying newly produced BoNT variants. Efforts should be made to clarify the biological and pharmacological characteristics of these novel BoNTs as well as the natural ones. The high potential of BoNTs as a therapeutic compound for medical syndromes lies on its ability to reach a specific cell type bypassing other cells, thus having mild or no side effects. In this paper the recent developments on BoNTs are reviewed with the aim to analyze the current knowledge on BoNTs biological mechanisms of action, immunogenicity, formulations, and therapeutic applications in the veterinary field, highlighting advantages and drawbacks and identifying the gaps to be filled in order to address research priorities.

show abstract

Endobronchial Injection of Botulinum Toxin for the Reduction of Bronchial Hyperreactivity Induced by Methacholine Inhalation in Dogs

Abstract: Endobronchial injection of BTX-A reduces bronchial hyperreactivity in the airways of healthy dogs.

Cited by 6 publications

References 10 publications

Safety and efficacy of botulinum toxin injection therapy for esophageal achalasia in Japan

Safety and efficacy of botulinum toxin injection therapy for esophageal achalasia in Japan

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

Contact Info

Product

Resources

About