Endobronchial intratumoral chemotherapy (EITC) followed by surgery in early non-small cell lung cancer with polypoid growth causing erroneous impression of advanced disease

Celikoğlu, S; Çelikoğlu, Firuz; Goldberg, Eugene P.

doi:10.1016/j.lungcan.2006.09.004

Cited by 32 publications

(32 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present work confirms and extends previously reported favorable experience with EITC (18,19). Considered together with the earlier studies, our observations demonstrate the feasability of restoring the patency of airways occluded by malignant airway obstruction using EITC as part of a multimodality treatment approach.…”

Section: Original Researchsupporting

confidence: 91%

See 1 more Smart Citation

Restoration of Patency to Central Airways Occluded by Malignant Endobronchial Tumors Using Intratumoral Injection of Cisplatin

et al. 2015

View full text Add to dashboard Cite

Rationale: Malignant airway obstruction is commonly found in patients with lung cancer and is associated with significant morbidity and mortality. Relieving malignant obstruction may improve symptoms, quality of life, and life expectancy.Objectives: The objective of this study was to analyze our experience with bronchoscopic endobronchial intratumoral injection of cisplatin for malignant airway obstruction. Methods:We conducted a retrospective analysis of patients with malignant airway obstruction treated with bronchoscopic intratumoral injection of cisplatin. Patient characteristics, histology, degree of airway obstruction, procedural methods, treatment cycles, performance status, and therapeutic outcomes were evaluated. Tumor response was analyzed based on bronchoscopic measurements performed on completion the of final treatment session. Adverse events and overall survival were abstracted. Measurements and Main Results:Between January 2009 and September 2014, 22 patients (10 men, 12 women; mean age 6 SD, 64.4 6 9.5 yr) were treated with one to four injections of 40 mg of cisplatin mixed in 40 ml of 0.9% NaCl. Treatments were completed 1 week apart. The primary etiologies of airway obstruction included squamous cell carcinoma (n = 11), adenocarcinoma (n = 6), small cell carcinoma (n = 2), large cell undifferentiated carcinoma (n = 1), and metastatic endobronchial cancer (n = 2). Twenty-one of 22 patients were evaluable for response. The majority of patients (15/21, 71.4%) responded to therapy, defined as greater than 50% relative reduction in obstruction from baseline. Treatment response was obtained regardless of tumor histology, concurrent systemic therapy, number of treatment cycles administered, performance status, or use of additional ablative interventions. Responders had significantly improved overall survival as compared with nonresponders, although the difference was small. Severe treatment-related side effects or complications were not observed.Conclusions: Subject to the limitations of a single-center retrospective study and a subjective primary outcome measure, we have demonstrated the feasibility of improving the patency of central airways that are largely or completely occluded by endobronchial malignant tumor using intraluminal injection of cisplatin. Additional longer-term, larger-scale safety and comparative effectiveness studies of this palliative treatment modality are warranted.

show abstract

Section: Original Researchsupporting

confidence: 91%

“…Massive hemoptysis also remains a concern, particularly with brachytherapy (15). Celikoglu and colleagues have observed and reported that direct injection of chemotherapeutic agents via needlecatheter into endobronchial tumors is effective at achieving airway patency and has long-lasting effect (16)(17)(18).…”

mentioning

confidence: 99%

Restoration of Patency to Central Airways Occluded by Malignant Endobronchial Tumors Using Intratumoral Injection of Cisplatin

et al. 2015

View full text Add to dashboard Cite

show abstract

“…As discussed in this review, we believe that EITC can be considered an important and effective neoadjuvant therapy for management of lung cancer [45][46][47][48][49][50]54,55]. As noted in Section 1.1, the majority of patients with NSC lung cancer have disease limited to the thorax, which makes the tumor mass easily accessible by bronchoscope.…”

Section: Intratumoral Injections Of Cytotoxic Drugsmentioning

confidence: 96%

“…In recent clinical studies, Celikoglu et al also demonstrated the practical clinical feasibility and effectiveness of intratumoral chemotherapy as a local neoadjuvant therapy in newly diagnosed lung cancer patients before radiotherapy [49] or before resection surgery [50]. In the comprehensive review of ''endobronchial intratumoral chemotherapy via-needle-catheter'' presented here our objective is to describe and teach this bronchoscopic intervention for relief of endobronchial obstruction and for use as a neoadjuvant chemotherapy procedure.…”

Section: Endobronchial Interventional Treatment Modalities In Generalmentioning

confidence: 99%

See 1 more Smart Citation

Bronchoscopic intratumoral chemotherapy of lung cancer

2008

Self Cite

View full text Add to dashboard Cite

Cytotoxicity of a Novel Oil/Water Microemulsion System Loaded with Mitomycin‐C in In Vitro Lung Cancer Models

Kotmakchiev

Kantarcı

Çetintaş

et al. 2012

Drug Development Research

View full text Add to dashboard Cite

The aim of the study was to develop a novel oil/water microemulsion system to increase the cytotoxic effect of mitomycin C (MMC) on human lung cancer cell lines through comparison to the conventional MMC solution. The microemulsion formulation was composed of soybean oil, lecithin, Tween 80, ethanol, and water. Characterization of the microemulsions was carried out by means of particle size, viscosity, conductivity, storage stability, in vitro drug release, and in vitro hemolysis. Putative anticancer activity was determined using Calu1 and A549 carcinoma cell lines with an XTT [2,3-bis-(2-methoxy-4nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] cell proliferation assay. Drug release from the MMCloaded microemulsion was sustained for more than 5 h while release from MMC solution was completed within 2 h. Based on the results of cytotoxicity study, a higher anticancer effect was observed with mitomycin C-loaded microemulsion (MMC-M), with IC50 values being approximately twofold to fourfold higher than that seen with the MMC solution on Calu1 and A549 carcinoma cell lines, respectively. In conclusion, MMC microemulsion has several advantages including slower drug release, a more pronounced anticancer effect at lower MMC doses, potentially leading to lower systemic toxicity potential if leakage occurs from the tumor site. Drug Dev Res 73 : 185-195, 2012.

show abstract

Endobronchial intratumoral chemotherapy (EITC) followed by surgery in early non-small cell lung cancer with polypoid growth causing erroneous impression of advanced disease

Cited by 32 publications

References 24 publications

Restoration of Patency to Central Airways Occluded by Malignant Endobronchial Tumors Using Intratumoral Injection of Cisplatin

Restoration of Patency to Central Airways Occluded by Malignant Endobronchial Tumors Using Intratumoral Injection of Cisplatin

Bronchoscopic intratumoral chemotherapy of lung cancer

Cytotoxicity of a Novel Oil/Water Microemulsion System Loaded with Mitomycin‐C in In Vitro Lung Cancer Models

Contact Info

Product

Resources

About