Endobronchial presentation of Hodgkin lymphoma: a review of the literature

Kiani, Bahram; Magro, Cynthia M.; Ross, Patrick

doi:10.1016/s0003-4975(03)00140-1

Cited by 29 publications

(19 citation statements)

References 39 publications

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“…10 Involved mediastinal nodes in classical HL may erode the lumen of a main lobar bronchus emulating an endobronchial tumor. [11][12][13] In all these forms, a PPHL can mimic the more commonly seen primary lung tumors, notably carcinomas. On radiology a PPHL has propensity to arise in the superior portions of the lung, whereas secondary pulmonary involvement by a systemic HL shows random miliary distribution without zonal predilection.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Kumar

Sidhu

Mistry

et al. 2008

Diagnostic Cytopathology

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Primary pulmonary Hodgkin's lymphoma (PPHL) is extremely rare. At an extranodal location such as the lung this lymphoma is likely to be confused with the more commonly occurring carcinomas at this site. We report the fine needle aspiration cytology (FNAC) findings of a PPHL in a 36-year-old male with a view to discuss the pitfalls and clues to the accurate cytologic diagnosis. This patient presented with a large, heterogeneously enhancing mass involving the anterior segment of right upper lobe without any evidence of nodal involvement. A CT-guided transthoracic FNAC of this mass revealed large connective tissue fragments with entrapped voluminous cells amidst a polymorphous population of eosinophils, polymorphs, and lymphocytes. The large cells showed abundant often stripped off cytoplasm, an irregular nucleus with nucleolus and were initially diagnosed as non-small cell carcinoma of the lung. In view of the locally advanced stage, patient received a carboplatin and gemcite-based chemotherapy with complete response but postchemotherapy patient refused local surgery. Two years later, the patient developed enlarged nodes which were diagnosed as Hodgkin's lymphoma, and a review of prior lung tumor confirmed the diagnosis of PPHL. Hence the rare diagnosis of PPHL should be kept in mind when a cytopathologist observes large cells embedded in collagenous tissue fragments with dominant cell dispersal amidst an inflammatory infiltrate in an aspirate from a primary lung tumor.

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Section: Discussionmentioning

confidence: 99%

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Kumar

Sidhu

Mistry

et al. 2008

Diagnostic Cytopathology

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“…Our patient had skeletal metastasis at the time of diagnosis; hence, the disease cannot be characterised as PPHL. Bronchoscopic findings of Hodgkin’s lymphoma as an endobronchial mass usually include an obstructing polypoid lesion, but sometimes presents as ulcerated mucosal infiltrates with slightly higher incidence of right bronchial tree involvement 4. Our patient had Hodgkin’s lymphoma presenting as an obstructing lesion of the left upper lobe mimicking primary lung cancer on bronchoscopy.…”

Section: Discussionmentioning

confidence: 74%

Hodgkin’s Lymphoma presenting as an obstructing endobronchial mass—A rare presentation

Abid¹,

Khan

Lone

2018

BMJ Case Reports

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We report a case of Hodgkin's lymphoma presenting as an endobronchial mass in a 40-year-old man with history of 8 months of non-specific symptoms like cough, fatigue and weight loss. Initially he was treated with broad-spectrum antibiotics for suspicion of pneumonia without recovery. Radiographic work-up showed cavitary consolidation of the upper lobe of the left lung, followed by bronchoscopy which showed obstructing mass of the upper lobe of the left lung mimicking primary lung carcinoma. Immunohistochemical staining of the specimen was suggestive of Hodgkin's lymphoma. The patient responded well to the chemotherapy regimen.

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“…In our recent review (5), the average age of presentation in these patients was 42.3 years (range 18 to 83 years), there was a slight preponderance of males, and cough was the most frequent sign. The lesions were typically polypoid, and there appeared to be a predilection for involvement of the right bronchial tree relative to the left bronchus (5).…”

Section: Discussionmentioning

confidence: 99%

“…The purpose of the present study was to explore the spectrum of endobronchial lesions in which pathological examination established a diagnosis other than primary pulmonary carcinoma. Three of these patients have been previously reported (3,5). The clinical features, including bronchoscopic assessment and pathological findings, are described.…”

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confidence: 99%

Endobronchial Mimics of Primary Endobronchial Carcinoma: A Clinical Study of 25 Cases

Magro

Ross

2005

Canadian Respiratory Journal

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While endobronchial lesions that present with symptoms of obstruction may be reflective of primary bronchogenic malignancy, there have been a number of reports of bronchial lesions other than primary bronchogenic carcinoma simulating primary endobronchial epithelial malignancy clinically. Twenty-five cases of symptomatic endobronchial disease were encountered with pathological assessment demonstrating an endobronchial process other than carcinoma, representing metastatic disease (breast, colon, renal, head and neck origin), fungal infection, Hodgkin's lymphoma, primary bronchogenic melanoma, lipoma, broncholith and inflammatory pseudopolyp. The present report underscores the potential pathogenetic heterogeneity encountered in lesions presenting with signs and symptoms of endobronchial obstruction, emphasizing the critical role of biopsy for establishing a definitive diagnosis.Key Words: Bronchus; Mimics of primary bronchogenic carcinoma; Tumour Simulation de cancer endobronchique primitif : étude clinique de 25 cas S'il est vrai que certaines lésions endobronchiques, qui se manifestent par des symptômes d'obstruction, peuvent être révélatrices d'un cancer bronchopulmonaire primitif, d'autres lésions bronchiques, différentes du cancer broncho-pulmonaire primitif, simulent, sur le plan clinique, une tumeur maligne primitive de l'épithélium endobronchique. À preuve : une étude de vingt-cinq cas de lésions endobronchiques symptomatiques dont l'examen pathologique faisait état de processus morbides évolutifs, différents du carcinome; parmi les affections en cause figuraient les métastases (cancer du sein, du côlon, du rein, de la tête et du cou), les infections fongiques, la maladie de Hodgkin, le mélanome bronchopulmonaire primitif, le lipome, la broncholithiase et les pseudopolypes inflammatoires. Le présent rapport fait ressortir l'hétérogénéité des affections possibles se manifestant par des signes et des symptômes d'obstruction endobronchique et, par le fait même, le rôle crucial de la biopsie pour poser un diagnostic formel. E ndobronchial lesions comprise a heterogeneous group of pathological entities. Regardless of their pathogenetic basis, similar obstructive signs and symptoms develop; hemoptysis, cough and/or dyspnea are characteristic. The most frequent pathogenetic basis is primary bronchogenic malignancy including bronchogenic small cell carcinoma, well-differentiated neuroendocrine carcinomas, bronchogenic squamous cell carcinoma and nonsmall cell carcinoma (1). However, previous reports (2-6) have reported other etiologies, including infection, lymphoma, endobronchial hamartomatous lesions, other rare forms of primary endobronchial neoplasia and finally, metastatic disease. The purpose of the present study was to explore the spectrum of endobronchial lesions in which pathological examination established a diagnosis other than primary pulmonary carcinoma. Three of these patients have been previously reported (3,5). The clinical features, including bronchoscopic assessment and pathological findings, are...

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Endobronchial presentation of Hodgkin lymphoma: a review of the literature

Cited by 29 publications

References 39 publications

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Primary pulmonary Hodgkin's lymphoma: A rare pitfall in transthoracic fine needle aspiration cytology

Hodgkin’s Lymphoma presenting as an obstructing endobronchial mass—A rare presentation

Endobronchial Mimics of Primary Endobronchial Carcinoma: A Clinical Study of 25 Cases

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